Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

[1]  T. Xiao,et al.  Post-translational regulation of inflammasomes , 2016, Cellular & Molecular Immunology.

[2]  Yitao Ding,et al.  Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro , 2016, Journal of Experimental & Clinical Cancer Research.

[3]  P. Watkins,et al.  Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury? , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[4]  G. Gores,et al.  Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. , 2016, Gastroenterology.

[5]  G. Gores,et al.  Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. , 2016, Journal of hepatology.

[6]  G. Gores,et al.  Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes , 2016, Hepatology.

[7]  C. Théry,et al.  Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes , 2016, Proceedings of the National Academy of Sciences.

[8]  M. Yin,et al.  Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner[S] , 2016, Journal of Lipid Research.

[9]  K. Kodys,et al.  Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation via TGF-β , 2016, Cellular and molecular gastroenterology and hepatology.

[10]  R. Schuster,et al.  Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. , 2016, Journal of hepatology.

[11]  D. Mukhopadhyay,et al.  Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration* , 2015, The Journal of Biological Chemistry.

[12]  K. Kodys,et al.  MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages* , 2015, The Journal of Biological Chemistry.

[13]  C. Hadjipanayis,et al.  Small extracellular vesicles as tumor biomarkers for glioblastoma. , 2015, Molecular aspects of medicine.

[14]  Gary K. Schwartz,et al.  Tumour exosome integrins determine organotropic metastasis , 2015, Nature.

[15]  A. Wong,et al.  Exosomes: Emerging biomarkers and targets for ovarian cancer. , 2015, Cancer letters.

[16]  D. Brigstock,et al.  Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1. , 2015, American journal of physiology. Gastrointestinal and liver physiology.

[17]  T. G. Grunewald,et al.  Tumour‐derived exosomes: Tiny envelopes for big stories , 2015, Biology of the cell.

[18]  K. Kodys,et al.  Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis , 2015, Journal of Translational Medicine.

[19]  S. Kong,et al.  Dysregulated Serum MicroRNA Expression Profile and Potential Biomarkers in Hepatitis C Virus-infected Patients , 2015, International journal of medical sciences.

[20]  J. Stapleton,et al.  Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection. , 2015, The Journal of general virology.

[21]  Ryan M. O’Connell,et al.  Exosome-delivered microRNAs modulate the inflammatory response to endotoxin , 2015, Nature Communications.

[22]  C. Lawson,et al.  Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells. , 2015, The British journal of nutrition.

[23]  O. Olivieri,et al.  Circadian exosomal expression of renal thiazide‐sensitive NaCl cotransporter (NCC) and prostasin in healthy individuals , 2015, Proteomics. Clinical applications.

[24]  Michael A. Hollingsworth,et al.  Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver , 2015, Nature Cell Biology.

[25]  J. Meldolesi,et al.  Ectosomes and exosomes: shedding the confusion between extracellular vesicles. , 2015, Trends in cell biology.

[26]  V. Ambros,et al.  Biodistribution and function of extracellular miRNA-155 in mice , 2015, Scientific Reports.

[27]  M Kersaudy-Kerhoas,et al.  Exosome isolation: a microfluidic road-map. , 2015, Lab on a chip.

[28]  K. Kodys,et al.  Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS , 2015, Scientific Reports.

[29]  Claudia Mongini,et al.  Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications , 2015, Front. Immunol..

[30]  P. Bedossa,et al.  Diagnosis of Liver Fibrosis: Present and Future , 2015, Seminars in Liver Disease.

[31]  Lei Yu,et al.  Investigation of the roles of exosomes in colorectal cancer liver metastasis. , 2015, Oncology reports.

[32]  L. Tomasello,et al.  Identification of Protein Tyrosine Phosphatase Receptor Gamma Extracellular Domain (sPTPRG) as a Natural Soluble Protein in Plasma , 2015, PloS one.

[33]  P. Myler,et al.  Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging , 2015, BMC Genomics.

[34]  K. Mimori,et al.  Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation , 2015, British Journal of Cancer.

[35]  L. O’Driscoll,et al.  Biological properties of extracellular vesicles and their physiological functions , 2015, Journal of extracellular vesicles.

[36]  Yuki Takahashi,et al.  Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice , 2015, Journal of extracellular vesicles.

[37]  A. Wree,et al.  Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease , 2014, PloS one.

[38]  R. Schiffelers,et al.  Extracellular Vesicles: Potential Roles in Regenerative Medicine , 2014, Front. Immunol..

[39]  G. Szabo,et al.  Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages. , 2014, Nanomedicine : nanotechnology, biology, and medicine.

[40]  K. Kodys,et al.  Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90 , 2014, PLoS pathogens.

[41]  M. Takigawa,et al.  Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver. , 2014, Surgery.

[42]  A. Willms,et al.  Extracellular Vesicle Profiling and Their Use as Potential Disease Specific Biomarker , 2014, Front. Immunol..

[43]  M. C. Martínez,et al.  Extracellular Vesicles as Therapeutic Tools in Cardiovascular Diseases , 2014, Front. Immunol..

[44]  Victor R. Ambros,et al.  Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis , 2014, Proceedings of the National Academy of Sciences.

[45]  Meg Duroux,et al.  A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy. , 2014, Biochimica et biophysica acta.

[46]  T. Chatila,et al.  Regulatory T cells: exosomes deliver tolerance. , 2014, Immunity.

[47]  S. Lim,et al.  Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models , 2014, Stem Cell Research & Therapy.

[48]  D. Thabut,et al.  The emerging roles of microvesicles in liver diseases , 2014, Nature Reviews Gastroenterology &Hepatology.

[49]  Shelly C. Lu,et al.  Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity. , 2014, Journal of proteomics.

[50]  Hongwei Wang,et al.  Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma , 2014, BioMed research international.

[51]  W. Kuo,et al.  Emerging technologies in extracellular vesicle-based molecular diagnostics , 2014, Expert review of molecular diagnostics.

[52]  Li Zhang,et al.  Chicken biliary exosomes enhance CD4(+)T proliferation and inhibit ALV-J replication in liver. , 2014, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[53]  P. Robbins,et al.  Regulation of immune responses by extracellular vesicles , 2014, Nature Reviews Immunology.

[54]  Andrew F. Hill,et al.  Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles , 2014, Journal of extracellular vesicles.

[55]  R. Nieuwland,et al.  Co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation , 2014, Journal of extracellular vesicles.

[56]  R. Pink,et al.  Routes and mechanisms of extracellular vesicle uptake , 2014, Journal of extracellular vesicles.

[57]  A. Feldstein,et al.  Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells , 2013, Science Signaling.

[58]  Winston Patrick Kuo,et al.  Current methods for the isolation of extracellular vesicles , 2013, Biological chemistry.

[59]  Stefano Fais,et al.  Exosomes: the future of biomarkers in medicine. , 2013, Biomarkers in medicine.

[60]  Nicholas F. LaRusso,et al.  Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. , 2013, Journal of hepatology.

[61]  Jiangxia Liu,et al.  Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity , 2013, Nature Immunology.

[62]  A. Aransay,et al.  Transcriptome of Extracellular Vesicles Released by Hepatocytes , 2013, PloS one.

[63]  Biana Godin,et al.  Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. , 2013, Lab on a chip.

[64]  A. Landay,et al.  GB Virus C Particles Inhibit T Cell Activation via Envelope E2 Protein-Mediated Inhibition of TCR Signaling , 2013, The Journal of Immunology.

[65]  J. Leonard,et al.  FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver , 2013, Pharmaceuticals.

[66]  B. Wang,et al.  Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. , 2013, Stem cells and development.

[67]  Hong Jiang,et al.  Intestinal mucus‐derived nanoparticle–mediated activation of Wnt/β‐catenin signaling plays a role in induction of liver natural killer T cell anergy in mice , 2013, Hepatology.

[68]  G. Camussi,et al.  Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth. , 2013, Stem cells and development.

[69]  Graça Raposo,et al.  Extracellular vesicles: Exosomes, microvesicles, and friends , 2013, The Journal of cell biology.

[70]  Lynne T. Bemis,et al.  Standardization of sample collection, isolation and analysis methods in extracellular vesicle research , 2013, Journal of extracellular vesicles.

[71]  P. Altevogt,et al.  Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation , 2012, PLoS biology.

[72]  J. Fallowfield,et al.  Biomarkers in Liver Disease: Emerging Methods and Potential Applications , 2012, International journal of hepatology.

[73]  K. Kodys,et al.  Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug‐induced, and inflammatory liver diseases , 2012, Hepatology.

[74]  F. Chisari,et al.  Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. , 2012, Cell host & microbe.

[75]  MITSURU CHIBA,et al.  Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines , 2012, Oncology reports.

[76]  D. Schuppan,et al.  Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis. , 2012, Gastroenterology.

[77]  M. Manns,et al.  Zakim and Boyer's hepatology , 2012 .

[78]  K. Kodys,et al.  Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection , 2012, Journal of Translational Medicine.

[79]  V. Paradis,et al.  Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis. , 2012, Gastroenterology.

[80]  R. Setterquist,et al.  Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. , 2012, Biochimica et biophysica acta.

[81]  J. Hurley,et al.  Get on the exosome bus with ALIX , 2012, Nature Cell Biology.

[82]  C. Chen,et al.  Exosome removal as a therapeutic adjuvant in cancer , 2012, Journal of Translational Medicine.

[83]  G. Camussi,et al.  Human Liver Stem Cell-Derived Microvesicles Inhibit Hepatoma Growth in SCID Mice by Delivering Antitumor MicroRNAs , 2012, Stem cells.

[84]  X. Wang,et al.  REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY , 2012 .

[85]  Li-hong Lv,et al.  Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responses in Vitro* , 2012, The Journal of Biological Chemistry.

[86]  E. Herrmann,et al.  Soluble Serum CD81 Is Elevated in Patients with Chronic Hepatitis C and Correlates with Alanine Aminotransferase Serum Activity , 2012, PloS one.

[87]  S. Mathivanan,et al.  Extracellular Microvesicles: The Need for Internationally Recognised Nomenclature and Stringent Purification Criteria , 2012 .

[88]  Richard J Simpson,et al.  Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. , 2012, Methods.

[89]  H. Hilton,et al.  The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities , 2011, Biochemical Pharmacology.

[90]  Wen-Lang Lin,et al.  Intercellular nanovesicle‐mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth , 2011, Hepatology.

[91]  B. Ferry,et al.  Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay. , 2011, Thrombosis research.

[92]  Clotilde Théry,et al.  Exosomes: immune properties and potential clinical implementations , 2011, Seminars in Immunopathology.

[93]  K. Kodys,et al.  Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease* , 2010, The Journal of Biological Chemistry.

[94]  K. Strimbu,et al.  What are biomarkers? , 2010, Current opinion in HIV and AIDS.

[95]  N. LaRusso,et al.  Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[96]  Johan Skog,et al.  Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease. , 2010, Kidney international.

[97]  Shelly C. Lu,et al.  Candidate biomarkers in exosome‐like vesicles purified from rat and mouse urine samples , 2010, Proteomics. Clinical applications.

[98]  A. Molinari,et al.  Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells* , 2009, The Journal of Biological Chemistry.

[99]  Graça Raposo,et al.  Exosomes--vesicular carriers for intercellular communication. , 2009, Current opinion in cell biology.

[100]  N. Kobayashi,et al.  Stem cell research and therapy for liver disease. , 2009, Current stem cell research & therapy.

[101]  Rong-Fong Shen,et al.  Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. , 2009, Biochemical and biophysical research communications.

[102]  R. Witek,et al.  Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. , 2009, Gastroenterology.

[103]  Rune Matthiesen,et al.  Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. , 2008, Journal of proteome research.

[104]  S. Brodsky,et al.  Dynamics of circulating microparticles in liver transplant patients. , 2008, Journal of gastrointestinal and liver diseases : JGLD.

[105]  W. Kim,et al.  Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease , 2008, Hepatology.

[106]  B. Quah,et al.  Exosomes Secreted by Bacterially Infected Macrophages Are Proinflammatory , 2008, Science Signaling.

[107]  J. Crawford,et al.  The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1 , 2008, Laboratory Investigation.

[108]  J. Dear,et al.  Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. , 2006, Kidney international.

[109]  Aled Clayton,et al.  Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.

[110]  Olivier Lantz,et al.  Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial , 2005, Journal of Translational Medicine.

[111]  H. Miyachi,et al.  Platelet activation in patients with chronic hepatitis C. , 2002, The Tokai journal of experimental and clinical medicine.

[112]  Graça Raposo,et al.  The Biogenesis and Functions of Exosomes , 2002, Traffic.

[113]  D. Demuth,et al.  Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin. , 2002, Microbial pathogenesis.

[114]  D. DeMets,et al.  Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework , 2001, Clinical pharmacology and therapeutics.