Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
暂无分享,去创建一个
L. Linares | J. Marine | F. Rambow | J. Portais | L. Le Cam | Maud Heuillet | Madi Y. Cissé | F. Bellvert | T. Levade | É. Bonneil | J. Sarry | F. Sabourdy | G. Arena | I. Ait-Arsa | Romain Riscal | C. Vincent | Emilie Schrepfer | Pierre Thibaut
[1] Shuang Huang,et al. KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism. , 2016, Cell reports.
[2] K. Vousden,et al. Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells , 2016, Molecular cell.
[3] S. Shieh,et al. Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation , 2015, Nucleic acids research.
[4] R. Deberardinis,et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer , 2015, Nature Genetics.
[5] M. V. Vander Heiden,et al. Lack of Evidence for PKM2 Protein Kinase Activity. , 2015, Molecular cell.
[6] M. V. Heiden,et al. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells , 2015, Cell.
[7] W. Gu,et al. Ferroptosis as a p53-mediated activity during tumour suppression , 2015, Nature.
[8] R. Deberardinis,et al. Metabolic pathways promoting cancer cell survival and growth , 2015, Nature Cell Biology.
[9] C. Su,et al. Identifying the determinants of response to MDM2 inhibition , 2015, Oncotarget.
[10] Wenwei Hu,et al. Tumor suppressor p53 and its mutants in cancer metabolism. , 2015, Cancer letters.
[11] W. Gu,et al. p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation* , 2014, The Journal of Biological Chemistry.
[12] M. Morello,et al. Bioinformatics analysis of the serine and glycine pathway in cancer cells , 2014, Oncotarget.
[13] Jiandong Chen,et al. Autoactivation of the MDM2 E3 Ligase by Intramolecular Interaction , 2014, Molecular and Cellular Biology.
[14] D. Lane,et al. Drugging the p53 pathway: understanding the route to clinical efficacy , 2014, Nature Reviews Drug Discovery.
[15] D. Lane,et al. Drugging the p53 pathway: understanding the route to clinical efficacy , 2014, Nature Reviews Drug Discovery.
[16] J. Manfredi,et al. p53-independent effects of Mdm2. , 2014, Sub-cellular biochemistry.
[17] Yunhong Zha,et al. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. , 2013, Cell metabolism.
[18] K. Vousden,et al. Metabolic Regulation by p53 Family Members , 2013, Cell metabolism.
[19] J. Locasale. Serine, glycine and one-carbon units: cancer metabolism in full circle , 2013, Nature Reviews Cancer.
[20] G. Wahl,et al. MDM2, MDMX and p53 in oncogenesis and cancer therapy , 2013, Nature Reviews Cancer.
[21] Karen Blyth,et al. Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells , 2012, Nature.
[22] Guillermina Lozano,et al. Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy , 2012, Clinical Cancer Research.
[23] V. Rotter,et al. Regulation of lipid metabolism by p53 – fighting two villains with one sword , 2012, Trends in Endocrinology & Metabolism.
[24] Eyal Gottlieb,et al. Serine is a natural ligand and allosteric activator of pyruvate kinase M2 , 2012, Nature.
[25] Wei Gu,et al. Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence , 2012, Cell.
[26] V. Mootha,et al. Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation , 2012, Science.
[27] J. Rabinowitz,et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation , 2012, Proceedings of the National Academy of Sciences.
[28] C. Prives,et al. Mdm2 and MdmX as Regulators of Gene Expression. , 2012, Genes & cancer.
[29] Jason W. Locasale,et al. Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses , 2011, Science.
[30] Gregory Stephanopoulos,et al. Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis , 2012, BMC Proceedings.
[31] 이연수. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer , 2011 .
[32] Hua Lu,et al. MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3* , 2010, The Journal of Biological Chemistry.
[33] J. Marine,et al. Mdm2-mediated ubiquitylation: p53 and beyond , 2010, Cell Death and Differentiation.
[34] B. K. Park,et al. MDM2 regulates dihydrofolate reductase activity through monoubiquitination. , 2008, Cancer research.
[35] G. Wahl,et al. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas , 2006, Nature Reviews Cancer.
[36] Tsonwin Hai,et al. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination , 2005, The EMBO journal.
[37] L. Mayo,et al. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[38] Patrick T. Reilly,et al. Loss of HCF-1–Chromatin Association Precedes Temperature-Induced Growth Arrest of tsBN67 Cells , 2001, Molecular and Cellular Biology.
[39] L. Donehower,et al. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[40] A. Levine,et al. Differential Regulation of the p21/WAF-1 and mdm2 Genes after High-Dose UV Irradiation: p53-Dependent and p53-Independent Regulation of the mdm2 Gene , 1997, Molecular medicine.
[41] Lawrence A. Donehower,et al. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 , 1995, Nature.
[42] Guillermina Lozano,et al. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 , 1995, Nature.
[43] T. Kinoshita,et al. The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. , 1994, Blood.
[44] A. Levine,et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. , 1994, Cancer research.
[45] M. Oren,et al. mdm2 expression is induced by wild type p53 activity. , 1993, The EMBO journal.
[46] A. Halestrap. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. , 1975, The Biochemical journal.