Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Optical waveguides and integrated optical devices are promising solutions for many applications, such as medical diagnosis, health monitoring and light therapies. Despite the many existing reviews focusing on the materials that these devices are made from, a systematic review that relates these devices to the various materials, fabrication processes, sensing methods and medical applications is still seldom seen. This work is intended to link these multidisciplinary fields, and to provide a comprehensive review of the recent advances of these devices. Firstly, the optical and mechanical properties of optical waveguides based on glass, polymers and heterogeneous materials and fabricated via various processes are thoroughly discussed, together with their applications for medical purposes. Then, the fabrication processes and medical implementations of integrated passive and active optical devices with sensing modules are introduced, which can be used in many medical fields such as drug delivery and cardiovascular healthcare. Thirdly, wearable optical sensing devices based on light sensing methods such as colorimetry, fluorescence and luminescence are discussed. Additionally, the wearable optical devices for light therapies are introduced. The review concludes with a comprehensive summary of these optical devices, in terms of their forms, materials, light sources and applications.

[1]  Zhihong Liu,et al.  Upconversion System with Quantum Dots as Sensitizer: Improved Photoluminescence and PDT Efficiency. , 2019, ACS applied materials & interfaces.

[2]  P. Wild,et al.  A fluorescence-based pH sensor with microfluidic mixing and fiber optic detection for wide range pH measurements , 2019, Sensors and Actuators A: Physical.

[3]  I. Samuel,et al.  Flexible organic light-emitting diodes for antimicrobial photodynamic therapy , 2019, npj Flexible Electronics.

[4]  Yong Ha Hwang,et al.  Recent Progress of Fiber Shaped Lighting Devices for Smart Display Applications—A Fibertronic Perspective , 2019, Advanced materials.

[5]  Qionghai Dai,et al.  Soft and Stretchable Polymeric Optical Waveguide-Based Sensors for Wearable and Biomedical Applications , 2019, Sensors.

[6]  C. Vázquez,et al.  Wearable POF-based heart-rate monitor , 2019, European Workshop on Optical Fibre Sensors.

[7]  Il-Joo Cho,et al.  Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo , 2019, Nature Communications.

[8]  P. Anikeeva,et al.  Next-generation interfaces for studying neural function , 2019, Nature Biotechnology.

[9]  Pavel Peterka,et al.  Multimaterial bioresorbable optical fibers for theranostics , 2019, European Conference on Biomedical Optics.

[10]  Huisheng Peng,et al.  Multifunctional Fibers to Shape Future Biomedical Devices , 2019, Advanced Functional Materials.

[11]  John A Rogers,et al.  Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves , 2019, Science Advances.

[12]  H. Stuppner,et al.  The photoactivity of natural products - An overlooked potential of phytomedicines? , 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[13]  Hugo Thienpont,et al.  Poly(D,L-Lactic Acid) (PDLLA) Biodegradable and Biocompatible Polymer Optical Fiber , 2019, Journal of Lightwave Technology.

[14]  Yufang Zhu,et al.  Dissolving Graphene/Poly(Acrylic Acid) Microneedles for Potential Transdermal Drug Delivery and Photothermal Therapy. , 2019, Journal of nanoscience and nanotechnology.

[15]  S. Ribeiro,et al.  Femtosecond direct laser writing of silk fibroin optical waveguides , 2019, Journal of Materials Science: Materials in Electronics.

[16]  Wei Gao,et al.  Wearable and flexible electronics for continuous molecular monitoring. , 2019, Chemical Society reviews.

[17]  Chris Castel,et al.  Novel technology platform for PBM delivery using printed LEDs , 2019, BiOS.

[18]  L. Tong,et al.  Au nanorod-coupled microfiber optical humidity sensors. , 2019, Optics express.

[19]  Andrea Farina,et al.  Bioresorbable fibers for time-domain diffuse optical measurements: a step toward next generation optical implantable devices , 2019, BiOS.

[20]  Wei Yan,et al.  Super-elastic multi-material optical fibers for healthcare applications , 2019, BiOS.

[21]  Nanshu Lu,et al.  Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics , 2019, Advanced Functional Materials.

[22]  Jayoung Kim,et al.  Wearable biosensors for healthcare monitoring , 2019, Nature Biotechnology.

[23]  Y. Fink,et al.  Flexible fiber-based optoelectronics for neural interfaces. , 2019, Chemical Society reviews.

[24]  P. Kramer,et al.  Potential Application of Optogenetic Stimulation in the Treatment of Pain and Migraine Headache: A Perspective from Animal Studies , 2019, Brain sciences.

[25]  Jeonghyun Kim,et al.  Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat , 2019, Science Advances.

[26]  H. Ebendorff‐Heidepriem,et al.  Soft-glass imaging microstructured optical fibers. , 2018, Optics express.

[27]  Yong Zhao,et al.  Highly-sensitive optical fiber temperature sensors based on PDMS/silica hybrid fiber structures , 2018, Sensors and Actuators A: Physical.

[28]  Conor L. Evans,et al.  Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages , 2018, Journal of biomedical optics.

[29]  Erin G Roberts,et al.  Fabrication and Characterization of Recombinant Silk-Elastin-Like-Protein (SELP) Fiber. , 2018, Macromolecular bioscience.

[30]  Donggeon Han,et al.  A flexible organic reflectance oximeter array , 2018, Proceedings of the National Academy of Sciences.

[31]  Fei Xu,et al.  Sensitive and Wearable Optical Microfiber Sensor for Human Health Monitoring , 2018, Advanced Materials Technologies.

[32]  L. Ye,et al.  Rapid and nondestructive measurement of glucose in a skin tissue phantom by near-infrared spectroscopy , 2018, Optik.

[33]  Chris Holland,et al.  The Biomedical Use of Silk: Past, Present, Future , 2018, Advanced healthcare materials.

[34]  Lei Wei,et al.  Advanced Multimaterial Electronic and Optoelectronic Fibers and Textiles , 2018, Advanced materials.

[35]  Xuemei Sun,et al.  Weaving Sensing Fibers into Electrochemical Fabric for Real‐Time Health Monitoring , 2018, Advanced Functional Materials.

[36]  T. Hasan,et al.  Development and evaluation of a low‐cost, portable, LED‐based device for PDT treatment of early‐stage oral cancer in resource‐limited settings , 2018, Lasers in surgery and medicine.

[37]  Zhiwen Liu,et al.  Polymeric biomaterials for biophotonic applications , 2018, Bioactive materials.

[38]  Xing Sheng,et al.  Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine , 2018, Materials.

[39]  Tyler R. Ray,et al.  A fluorometric skin-interfaced microfluidic device and smartphone imaging module for in situ quantitative analysis of sweat chemistry. , 2018, Lab on a chip.

[40]  U. Egert,et al.  Optogenetic entrainment of neural oscillations with hybrid fiber probes , 2018, Journal of neural engineering.

[41]  R. Rossi,et al.  Superelastic Multimaterial Electronic and Photonic Fibers and Devices via Thermal Drawing , 2018, Advanced materials.

[42]  Ali Khademhosseini,et al.  Wearables in Medicine , 2018, Advanced materials.

[43]  Fengming Ye,et al.  Ultrasoft and Highly Stretchable Hydrogel Optical Fibers for In Vivo Optogenetic Modulations , 2018, Advanced Optical Materials.

[44]  Jiahao Yu,et al.  Optical waveguiding properties of colloidal quantum dots doped polymer microfibers. , 2018, Optics express.

[45]  Wei Yan,et al.  Integration of High-performance Optoelectronic Nanowire-based Devices at Optical Fiber Tips , 2018, 2018 Conference on Lasers and Electro-Optics (CLEO).

[46]  Anders Pors,et al.  Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring , 2018, PloS one.

[47]  Q. Lu,et al.  Bioactive Silk Hydrogels with Tunable Mechanical Properties. , 2018, Journal of materials chemistry. B.

[48]  Raymond J Lanzafame,et al.  Flexible quantum dot light‐emitting devices for targeted photomedical applications , 2018, Journal of the Society for Information Display.

[49]  Gaoming Jiang,et al.  Textile Display for Electronic and Brain‐Interfaced Communications , 2018, Advanced materials.

[50]  Yong-Kweon Kim,et al.  Disposable MEMS optrode array integrated with single LED for neurostimulation , 2018 .

[51]  Sayantan Pradhan,et al.  Micropatterned conductive polymer biosensors on flexible PDMS films , 2018 .

[52]  Herbert Riechelmann,et al.  Photodynamic Effect of Methylene Blue and Low Level Laser Radiation in Head and Neck Squamous Cell Carcinoma Cell Lines , 2018, International journal of molecular sciences.

[53]  Haider Butt,et al.  Microfluidic Contact Lenses , 2018, Small.

[54]  Kyoung-Chan Park,et al.  A Wearable Photobiomodulation Patch Using a Flexible Red‐Wavelength OLED and Its In Vitro Differential Cell Proliferation Effects , 2018 .

[55]  Ali Javey,et al.  Wearable sweat sensors , 2018 .

[56]  S. Yun,et al.  Multifunctional Photonic Nanomaterials for Diagnostic, Therapeutic, and Theranostic Applications , 2018, Advanced materials.

[57]  K. Solt,et al.  Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model , 2018, Neurobiology of Disease.

[58]  John S. Ho,et al.  In vivo wireless photonic photodynamic therapy , 2018, Proceedings of the National Academy of Sciences.

[59]  Zhe Qu,et al.  Skin-like biosensor system via electrochemical channels for noninvasive blood glucose monitoring , 2017, Science Advances.

[60]  Sergey L. Gratiy,et al.  Fully integrated silicon probes for high-density recording of neural activity , 2017, Nature.

[61]  E. Tarte,et al.  Development and application of LED arrays for use in phototherapy research , 2017, Journal of biophotonics.

[62]  Zhiwen Liu,et al.  Flexible biodegradable citrate-based polymeric step-index optical fiber. , 2017, Biomaterials.

[63]  Jianfei Dong,et al.  Applications of Light Emitting Diodes in Health Care , 2017, Annals of Biomedical Engineering.

[64]  S. Yun,et al.  Biomaterial microlasers implantable in the cornea, skin, and blood. , 2017, Optica.

[65]  David L. Kaplan,et al.  The optical properties of regenerated silk fibroin films obtained from different sources , 2017 .

[66]  B. Shyu,et al.  Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice , 2017, Molecular Brain.

[67]  Hyung-Jin Kim,et al.  In vivo photothermal treatment with real-time monitoring by optical fiber-needle array. , 2017, Biomedical optics express.

[68]  Harald Sontheimer,et al.  Polymer Composite with Carbon Nanofibers Aligned during Thermal Drawing as a Microelectrode for Chronic Neural Interfaces. , 2017, ACS nano.

[69]  Michael R Hamblin Mechanisms and applications of the anti-inflammatory effects of photobiomodulation , 2017, AIMS biophysics.

[70]  Sheldon J. J. Kwok,et al.  Flexible Optical Waveguides for Uniform Periscleral Cross-Linking , 2017, Investigative ophthalmology & visual science.

[71]  Mesut Sahin,et al.  Polydimethylsiloxane-based optical waveguides for tetherless powering of floating microstimulators , 2017, Journal of biomedical optics.

[72]  Yan Wang,et al.  Synthetic Engineering of Spider Silk Fiber as Implantable Optical Waveguides for Low-Loss Light Guiding. , 2017, ACS applied materials & interfaces.

[73]  Lingxin Chen,et al.  Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy. , 2017, Chemical Society reviews.

[74]  S. Oh,et al.  Optogenetic Rescue of Locomotor Dysfunction and Dopaminergic Degeneration Caused by Alpha-Synuclein and EKO Genes , 2017, Experimental neurobiology.

[75]  Jianhua Shen,et al.  A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose , 2017, Polymers.

[76]  Ege Iseri,et al.  Implantable optoelectronic probes for in vivo optogenetics , 2017, Journal of neural engineering.

[77]  T. Park,et al.  Diverse Applications of Nanomedicine , 2017, ACS nano.

[78]  P. Anikeeva,et al.  Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits , 2017, Science Advances.

[79]  Ali K. Yetisen,et al.  Toward biomaterial-based implantable photonic devices , 2017 .

[80]  Y. S. Zhang,et al.  Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid , 2017, Advanced materials.

[81]  Sang Youn Han,et al.  Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics , 2017, Neuron.

[82]  X. Jia,et al.  One-Step Optogenetics with Multifunctional Flexible Polymer Fibers , 2017, Nature Neuroscience.

[83]  Polina Anikeeva,et al.  Neural Recording and Modulation Technologies. , 2017, Nature reviews. Materials.

[84]  Jinlian Hu,et al.  Waterborne polyurethane based thermoelectric composites and their application potential in wearable thermoelectric textiles , 2016 .

[85]  Seok Hyun Yun,et al.  Light in diagnosis, therapy and surgery , 2016, Nature Biomedical Engineering.

[86]  Tianhong Dai,et al.  Optical lens-microneedle array for percutaneous light delivery. , 2016, Biomedical optics express.

[87]  Jochen Guck,et al.  Materials and technologies for soft implantable neuroprostheses , 2016, Nature Reviews Materials.

[88]  Mesut Sahin,et al.  A PDMS-based optical waveguide for transcutaneous powering of microelectrode arrays , 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[89]  Kai Huang,et al.  Nanomaterial mediated optogenetics: opportunities and challenges , 2016 .

[90]  Michael R. Hamblin,et al.  Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy , 2016, IEEE Journal of Selected Topics in Quantum Electronics.

[91]  Silvio Abrate,et al.  Novel biocompatible and resorbable UV-transparent phosphate glass based optical fiber , 2016 .

[92]  Satoshi Konishi,et al.  Integration of optical waveguide on pneumatic balloon actuator for flexible scanner in endoscopic imaging diagnosis applications , 2016, Adv. Robotics.

[93]  M. Kaltenbrunner,et al.  Ultraflexible organic photonic skin , 2016, Science Advances.

[94]  George K. Knopf,et al.  Fabrication of large area flexible PDMS waveguide sheets , 2016, SPIE OPTO.

[95]  Chang Ming Li,et al.  Silk fabric-based wearable thermoelectric generator for energy harvesting from the human body , 2016 .

[96]  Giuliano Scarcelli,et al.  Bioabsorbable polymer optical waveguides for deep-tissue photomedicine , 2016, Nature Communications.

[97]  Yong-Lae Park,et al.  Highly stretchable optical sensors for pressure, strain, and curvature measurement , 2015, 2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS).

[98]  Christophe Moser,et al.  Miniature probe for the delivery and monitoring of a photopolymerizable material , 2015, Journal of biomedical optics.

[99]  F. Omenetto,et al.  Biocompatible silk step-index optical waveguides. , 2015, Biomedical optics express.

[100]  Bin Fan,et al.  Micro-lens-coupled LED neural stimulator for optogenetics , 2015, 2015 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[101]  J. Y. Sim,et al.  Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics , 2015, Cell.

[102]  Seonghoon Kim,et al.  Step‐Index Optical Fiber Made of Biocompatible Hydrogels , 2015, Advanced materials.

[103]  Suzie Dufour,et al.  Optrodes for combined optogenetics and electrophysiology in live animals , 2015, Neurophotonics.

[104]  Udi Nussinovitch,et al.  Optogenetics for in vivo cardiac pacing and resynchronization therapies , 2015, Nature Biotechnology.

[105]  S. Tonegawa,et al.  Activating positive memory engrams suppresses depression-like behaviour , 2015, Nature.

[106]  Bernd K. Fleischmann,et al.  Optogenetic control of contractile function in skeletal muscle , 2015, Nature Communications.

[107]  Ji Hoon Kim,et al.  Wearable red–green–blue quantum dot light-emitting diode array using high-resolution intaglio transfer printing , 2015, Nature Communications.

[108]  Vasudevan Lakshminarayananan,et al.  Optical techniques in optogenetics , 2015, Journal of modern optics.

[109]  Sumin Yun,et al.  Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases. , 2015, ACS nano.

[110]  Michael R. Hamblin,et al.  Low level laser (light) therapy and photobiomodulation: the path forward , 2015, Photonics West - Biomedical Optics.

[111]  S. Konishi,et al.  Flexible end-effector integrated with scanning actuator and optical waveguide for endoscopic fluorescence imaging diagnosis , 2015, 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS).

[112]  Hongxia Wang,et al.  Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy? , 2015, Brain Research Bulletin.

[113]  Christina M. Tringides,et al.  Multifunctional fibers for simultaneous optical, electrical and chemical interrogation of neural circuits in vivo , 2015, Nature Biotechnology.

[114]  Bin Fan,et al.  An implantable, miniaturized SU-8 optical probe for optogenetics-based deep brain stimulation , 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[115]  Gian-Luca Bona,et al.  An Optical Fibre-Based Sensor for Respiratory Monitoring , 2014, Sensors.

[116]  Giancarlo C. Righini,et al.  Glass optical waveguides: a review of fabrication techniques , 2014 .

[117]  Ivan Martincek,et al.  Technology for the Preparation of PDMS Optical Fibers and Some Fiber Structures , 2014, IEEE Photonics Technology Letters.

[118]  Dim-Lee Kwong,et al.  Development of silicon electrode enhanced by carbon nanotube and gold nanoparticle composites on silicon neural probe fabricated with complementary metal-oxide-semiconductor process , 2014 .

[119]  K. L. Montgomery,et al.  Virally mediated optogenetic excitation and inhibition of pain in freely moving non-transgenic mice , 2014, Nature Biotechnology.

[120]  Jing Shen,et al.  Luminous fabric devices for wearable low-level light therapy. , 2013, Biomedical optics express.

[121]  Seok Hyun Yun,et al.  Light-guiding hydrogels for cell-based sensing and optogenetic synthesis in vivo , 2013, Nature Photonics.

[122]  Jing Wang,et al.  A coaxial optrode as multifunction write-read probe for optogenetic studies in non-human primates , 2013, Journal of Neuroscience Methods.

[123]  G. Buzsáki,et al.  An implantable neural probe with monolithically integrated dielectric waveguide and recording electrodes for optogenetics applications , 2013, Journal of neural engineering.

[124]  Yen-Chung Chang,et al.  A flexible hydrophilic-modified graphene microprobe for neural and cardiac recording. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[125]  Steffen B. E. Wolff,et al.  A polymer-based neural microimplant for optogenetic applications: design and first in vivo study. , 2013, Lab on a chip.

[126]  Dermot Diamond,et al.  Real-time sweat pH monitoring based on a wearable chemical barcode micro-fluidic platform incorporating ionic liquids , 2012 .

[127]  Volker Busskamp,et al.  Optogenetic approaches to restoring visual function in retinitis pigmentosa , 2011, Current Opinion in Neurobiology.

[128]  Mostafa A. El-Sayed,et al.  Plasmonic photo-thermal therapy (PPTT) , 2011 .

[129]  Timothy D. Soper,et al.  Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide‐field, full‐color imaging , 2010, Journal of biophotonics.

[130]  Xu Wu,et al.  The Mitochondrial Pathway of Anesthetic Isoflurane-induced Apoptosis* , 2009, The Journal of Biological Chemistry.

[131]  A. Khoddami,et al.  Overview of Poly(lactic acid) (PLA) Fibre , 2009 .

[132]  B. Connors,et al.  Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue , 2009, Journal of neural engineering.

[133]  H Abrahamse,et al.  Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT. , 2009, Journal of photochemistry and photobiology. B, Biology.

[134]  M. Hirano,et al.  Silica-Based Highly Nonlinear Fibers and Their Application , 2009, IEEE Journal of Selected Topics in Quantum Electronics.

[135]  C. Dubois,et al.  Fabrication strategies and potential applications of the "green" microstructured optical fibers. , 2008, Journal of biomedical optics.

[136]  Guy Voirin,et al.  Wearable Biosensors for Monitoring Wound Healing , 2008 .

[137]  Jeff Blyth,et al.  Towards the real-time monitoring of glucose in tear fluid: holographic glucose sensors with reduced interference from lactate and pH. , 2008, Biosensors & bioelectronics.

[138]  G. Luker,et al.  Optical Imaging: Current Applications and Future Directions , 2007, Journal of Nuclear Medicine.

[139]  Nicolas Godbout,et al.  Prospective for biodegradable microstructured optical fibers. , 2007, Optics letters.

[140]  R. Bellamkonda,et al.  Biomechanical analysis of silicon microelectrode-induced strain in the brain , 2005, Journal of neural engineering.

[141]  Simon D Tran,et al.  Saliva as a diagnostic tool for oral and systemic diseases. , 2016, Journal of oral biology and craniofacial research.

[142]  Tanya Vanessa F. Abaya,et al.  Implantable light delivery interfaces for optical neural stimulation , 2013 .

[143]  Hung Cao,et al.  An Integrated μLED Optrode for Optogenetic Stimulation and Electrical Recording , 2013, IEEE Transactions on Biomedical Engineering.