Quantitative correlation studies between the acute lethal toxicity of 15 organic halides to the guppy (Poecillah Reticulata) and chemical reactivity towards 4‐nitrobenzylpyridine

The acute mortality (14‐day LC50) to the guppy (Poecilia reticulata) of reactive organic halides was determined. These compounds were significantly more toxic than the non‐reactive organic chemicals with unspecific toxicity. The 14‐day LC50 of 15 compounds was correlated with hydrophobicity (P oct) and a chemical reactivity parameter (reaction rate constants with 4‐nitrobenzylpyridine). The quality of the QSAR with chemical reactivity as parameter was much better than of a QSAR with P oct

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