Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.
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A. Patchett | J. Schaeffer | R. Mosley | A. Pasternak | S. Rohrer | E. Birzin | P. Sanderson | K. Cheng | T. Jacks | Dominick Marino | S. Huskey | Y. Pan | K. Schleim | L. Yang | Y. Pan
[1] A. Patchett,et al. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. , 1998, Journal of medicinal chemistry.
[2] C. Stidsen,et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity , 1998 .
[3] G. Liapakis,et al. Identification of Ligand Binding Determinants in the Somatostatin Receptor Subtypes 1 and 2* , 1996, The Journal of Biological Chemistry.
[4] G. Liapakis,et al. Development of a selective agonist at the somatostatin receptor subtype sstr1. , 1996, The Journal of pharmacology and experimental therapeutics.
[5] E. Ravussin,et al. Metabolic differences and the development of obesity. , 1995, Metabolism: clinical and experimental.
[6] C. B. Srikant,et al. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). , 1994, Endocrinology.
[7] P. Darke,et al. Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport. , 1994, Journal of medicinal chemistry.
[8] Joseph M. Salvino,et al. De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing beta-D-glucose as a novel scaffolding , 1993 .
[9] T. Reisine,et al. Main chain and side chain chiral methylated somatostatin analogs : syntheses and conformational analyses , 1992 .
[10] C. Saper,et al. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. , 1992, The Journal of biological chemistry.
[11] J. Vida,et al. Conformationally directed drug design : peptides and nucleic acids as templates or targets : based on a symposium sponsored by the Division of Medicinal Chemistry at the 186th Meeting of the American Chemical Society, Washington, D.C., August 28-September 2, 1983 , 1984 .
[12] C. J. Goodner,et al. Effects of somatostatin on hemostasis in baboons. , 1975, The New England journal of medicine.
[13] G. Grodsky,et al. Inhibition by somatostatin of glucagon and insulin release from the perfused rat pancreas in response to arginine, isoproterenol and theophylline: evidence for a preferential effect on glucagon secretion. , 1975, Endocrinology.
[14] N. Ling,et al. Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone , 1973, Science.
[15] S. Efendić,et al. Effects of somatostatin on gastrointestinal propagation and absorption of oral glucose in man. , 1981, Digestion.