Sub-wavelength grating for enhanced ring resonator biosensor.

While silicon photonic resonant cavities have been widely investigated for biosensing applications, enhancing their sensitivity and detection limit continues to be an area of active research. Here, we describe how to engineer the effective refractive index and mode profile of a silicon-on-insulator (SOI) waveguide using sub-wavelength gratings (SWG) and report on its observed performance as a biosensor. We designed a 30 μm diameter SWG ring resonator and fabricated it using Ebeam lithography. Its characterization resulted in a quality factor, Q, of 7 · 103, bulk sensitivity Sb = 490 nm/RIU, and system limit of detection sLoD = 2 · 10-6 RIU. Finally we employ a model biological sandwich assay to demonstrate its utility for biosensing applications.

[1]  Amadeu Griol,et al.  Label-free optical biosensing with slot-waveguides. , 2008, Optics letters.

[2]  Lehmann,et al.  Adsorption and Bioactivity of Protein A on Silicon Surfaces Studied by AFM and XPS. , 2001, Journal of colloid and interface science.

[3]  Y. Fainman,et al.  Inhomogenous dielectric metamaterials with space-variant polarizability. , 2007, Physical review letters.

[4]  Pavel Cheben,et al.  Evanescent field waveguide sensing with subwavelength grating structures in silicon-on-insulator. , 2014, Optics letters.

[5]  Lukas Chrostowski,et al.  Sub-wavelength grating components for integrated optics applications on SOI chips. , 2014, Optics express.

[6]  Wei Shi,et al.  Silicon photonic micro-disk resonators for label-free biosensing. , 2013, Optics express.

[7]  Damià Barceló,et al.  Biosensors for environmental monitoring A global perspective. , 2005, Talanta.

[8]  Roel Baets,et al.  SOI optical microring resonator with poly(ethylene glycol) polymer brush for label-free biosensor applications. , 2009, Biosensors & bioelectronics.

[9]  Z Weissman Evanescent field sensors with periodically segmented waveguides. , 1997, Applied optics.

[10]  Janos Vörös,et al.  The density and refractive index of adsorbing protein layers. , 2004, Biophysical journal.

[11]  Lukas Chrostowski,et al.  Precise control of the coupling coefficient through destructive interference in silicon waveguide Bragg gratings. , 2014, Optics letters.

[12]  Ivan Glesk,et al.  Subwavelength grating filtering devices. , 2014, Optics express.

[13]  Michael Hochberg,et al.  Towards fabless silicon photonics , 2010 .

[14]  Wei Shi,et al.  Focusing sub-wavelength grating couplers with low back reflections for rapid prototyping of silicon photonic circuits. , 2014, Optics express.

[15]  P. Bienstman,et al.  Conformational analysis of proteins with a dual polarisation silicon microring. , 2014, Optics express.

[16]  J J Burke,et al.  Linear propagation characteristics of periodically segmented waveguides. , 1992, Optics letters.

[17]  M. Roukes,et al.  Comparative advantages of mechanical biosensors. , 2011, Nature nanotechnology.

[18]  L. C. Gunn,et al.  Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators. , 2009, Analytical chemistry.

[19]  A. Scherer,et al.  Design and fabrication of silicon photonic crystal optical waveguides , 2000, Journal of Lightwave Technology.

[20]  R. Soref,et al.  The Past, Present, and Future of Silicon Photonics , 2006, IEEE Journal of Selected Topics in Quantum Electronics.

[21]  Haishan Zeng,et al.  Perfectly registered multiphoton and reflectance confocal video rate imaging of in vivo human skin , 2013, Journal of biophotonics.

[22]  Siva Yegnanarayanan,et al.  Toward ultimate miniaturization of high Q silicon traveling-wave microresonators. , 2010, Optics express.

[23]  Petr I. Nikitin,et al.  Picoscope, a new label-free biosensor , 2005 .

[24]  H. Salemink,et al.  Photonic crystal-based all-optical on-chip sensor. , 2012, Optics express.

[25]  Rajan P Kulkarni,et al.  Label-Free, Single-Molecule Detection with Optical Microcavities , 2007, Science.

[26]  S. Arnold,et al.  Single virus detection from the reactive shift of a whispering-gallery mode , 2008, Proceedings of the National Academy of Sciences.

[27]  Muzammil Iqbal,et al.  Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[28]  R. Baets,et al.  Silicon-on-Insulator microring resonator for sensitive and label-free biosensing. , 2007, Optics express.

[29]  V. M. Murukeshan,et al.  Compact SOI nanowire refractive index sensor using phase shifted Bragg grating. , 2009, Optics express.

[30]  J. Sjöquist,et al.  Protein A as a molecular probe for the detection of antigen induced conformational change in Fc region of rabbit antibody. , 1981, Molecular immunology.

[31]  R. J. Bojko,et al.  Quantitative lithographic performance of proximity correction for electron beam lithography , 1990 .

[32]  P. Bienstman,et al.  Label-Free Biosensing With a Slot-Waveguide-Based Ring Resonator in Silicon on Insulator , 2009, IEEE Photonics Journal.

[33]  Shon Schmidt,et al.  A silicon photonic biosensor using phase‐shifted Bragg gratings in slot waveguide , 2013, Journal of biophotonics.

[34]  David J. Thomson,et al.  Silicon optical modulators , 2010 .

[35]  Siegfried Janz,et al.  Subwavelength grating periodic structures in silicon-on-insulator: a new type of microphotonic waveguide. , 2010, Optics express.

[36]  Jonathan P. Dowling,et al.  Anomalous Index of Refraction in Photonic Bandgap Materials , 1994 .

[37]  Lukas Chrostowski,et al.  Performance of ultra-thin SOI-based resonators for sensing applications. , 2014, Optics express.

[38]  Z. Weissman,et al.  Analysis of periodically segmented waveguide mode expanders , 1995 .

[39]  Michael Hochberg,et al.  Zwitterionic polymer-modified silicon microring resonators for label-free biosensing in undiluted human plasma. , 2013, Biosensors & bioelectronics.

[40]  Göran Stemme,et al.  On-chip temperature compensation in an integrated slot-waveguide ring resonator refractive index sensor array. , 2010, Optics express.

[41]  Lukas Chrostowski,et al.  Design and fabrication of SOI micro-ring resonators based on sub-wavelength grating waveguides. , 2015, Optics express.

[42]  Siegfried Janz,et al.  Waveguide sub‐wavelength structures: a review of principles and applications , 2015 .

[43]  Melinda S. McClellan,et al.  Label-free virus detection using silicon photonic microring resonators. , 2012, Biosensors & bioelectronics.

[44]  Jing Li,et al.  Electron beam lithography writing strategies for low loss, high confinement silicon optical waveguides , 2011 .

[45]  Siegfried Janz,et al.  Subwavelength grating crossings for silicon wire waveguides. , 2010, Optics express.

[46]  P. Cheben,et al.  Subwavelength waveguide grating for mode conversion and light coupling in integrated optics. , 2006, Optics express.

[47]  Muzammil Iqbal,et al.  Characterization of the evanescent field profile and bound mass sensitivity of a label-free silicon photonic microring resonator biosensing platform. , 2010, Biosensors & bioelectronics.

[48]  John E. Bowers,et al.  Silicon-based on-chip multiplexing technologies and devices for Peta-bit optical interconnects , 2014 .

[49]  Adam L. Washburn,et al.  Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads. , 2011, Lab on a chip.

[50]  Marcus Textor,et al.  A comparative study of protein adsorption on titanium oxide surfaces using in situ ellipsometry, optical waveguide lightmode spectroscopy, and quartz crystal microbalance/dissipation , 2002 .