Precision medicine as an approach to autoimmune diseases

Abstract Autoimmune disease, which are quite common, are complex and heterogeneous conditions that can be difficult to diagnose, treat and manage. Consequently, this group of disease generates a major burden on global health care systems. Despite significant efforts and advances in the field of autoimmunity, challenges persist that require a more precise approach to potentially leveraging big data composed of demographic, clinical and biomarker data combined with augmented intelligence. This book chapter provides a high-level overview of some of the challenges in autoimmunity and elaborates on progress to date.