A novel technique for detecting suspicious lesions in breast ultrasound images

We present a new method for automatic detection of suspicious breast cancer lesions using ultrasound. The system is fully automated. It uses fuzzy logic and compounding for de‐noising. A fuzzy membership function based on the gray values of ultrasound images is applied for de‐noising, improving the quality of the image and increasing separation between foreground and background, thus making easier detection of lesions. A novel approach based on neural network is used for segmentation of ultrasound images, and correlation between ultrasound images taken from different angles allows overcoming the problem of shadowing. We consider a combination of morphological and texture features and use sequential forward search, sequential backward search, and distance‐based method to select the best subset of features. We rank the features using distance‐based method and use a combination of sequential forward search and sequential backward search to select the best features (bidirectional search). Finally, support vector machine classifier is used for detecting suspicious lesions. The results of experiments show that our system performs better than other state‐of‐the‐art computer‐aided diagnosis systems with the accuracy of 98.75%. Furthermore, we used concurrency to improve the computational efficiency. In concurrent implementation of de‐noising, segmentation, and feature selection and extraction, we assign each pixel of an ultrasound image to a different thread. We also benefit from multi‐core computing by running each classifier on a different thread. Concurrent implementation of our computer‐aided diagnosis system reduces overall computational time by 85%. Copyright © 2015 John Wiley & Sons, Ltd.

[1]  Devarajan Sridharan,et al.  Automatic Identification of Ultrasound Liver Cancer Tumor Using Support Vector Machine , 2012 .

[2]  D. Chen,et al.  Computer-aided diagnosis applied to US of solid breast nodules by using neural networks. , 1999, Radiology.

[3]  Wagner Coelho A. Pereira,et al.  Analysis of Co-Occurrence Texture Statistics as a Function of Gray-Level Quantization for Classifying Breast Ultrasound , 2012, IEEE Transactions on Medical Imaging.

[4]  Moi Hoon Yap,et al.  A novel algorithm for initial lesion detection in ultrasound breast images , 2008, Journal of applied clinical medical physics.

[5]  W. Wayt Gibbs,et al.  Untangling the roots of cancer. , 2003, Scientific American.

[6]  M. Giger,et al.  Computerized lesion detection on breast ultrasound. , 2002, Medical physics.

[7]  Jeon-Hor Chen,et al.  Computer-aided classification of breast masses using speckle features of automated breast ultrasound images. , 2012, Medical physics.

[8]  Maruyama Kenjiro,et al.  A study for reduction of speckle noise in Medical Ultrasonic Images using Neural Network , 2007 .

[9]  Tamer Ölmez,et al.  Segmentation of ultrasound images by using a hybrid neural network , 2002, Pattern Recognit. Lett..

[10]  Maryellen L. Giger,et al.  Automated Method for Improving System Performance of Computer-Aided Diagnosis in Breast Ultrasound , 2009, IEEE Transactions on Medical Imaging.

[11]  Hiroshi Fujita,et al.  Computerized mass detection in whole breast ultrasound images: reduction of false positives using bilateral subtraction technique , 2007, SPIE Medical Imaging.

[12]  Lotfi A. Zadeh,et al.  The concept of a linguistic variable and its application to approximate reasoning-III , 1975, Inf. Sci..

[13]  S. Suresh,et al.  Feature Extraction for Characterization of Breast Lesions in Ultrasound Echography and Elastography , 2010 .

[14]  Le Hoang Thai,et al.  Image Classification using Support Vector Machine and Artificial Neural Network , 2012 .

[15]  Dimitris N. Metaxas,et al.  Combining low-, high-level and empirical domain knowledge for automated segmentation of ultrasonic breast lesions , 2003, IEEE Transactions on Medical Imaging.

[16]  Ruey-Feng Chang,et al.  Automatic ultrasound segmentation and morphology based diagnosis of solid breast tumors , 2004, Breast Cancer Research and Treatment.

[17]  Savita Gupta,et al.  An information fusion based method for liver classification using texture analysis of ultrasound images , 2014, Inf. Fusion.

[18]  Prema T. Akkasaligar,et al.  Speckle Noise Reduction in Medical Ultrasound Images , 2013 .

[19]  Ali S. Saad Simultaneous speckle reduction and contrast enhancement for ultrasound images: Wavelet versus Laplacian pyramid , 2008, Pattern Recognition and Image Analysis.

[20]  Robert LIN,et al.  NOTE ON FUZZY SETS , 2014 .

[21]  Savita Gupta,et al.  Robust non-homomorphic approach for speckle reduction in medical ultrasound images , 2006, Medical and Biological Engineering and Computing.

[22]  Yung-Sheng Chen,et al.  A disk expansion segmentation method for ultrasonic breast lesions , 2009, Pattern Recognit..

[23]  P. Thangaraj,et al.  Improved Gabor Filter for Extracting Texture Edge Features in Ultrasound Kidney Images , 2010 .

[24]  R. Sudhakar,et al.  Automatic Classification of Liver Diseases from Ultrasound Images Using GLRLM Texture Features , 2012, SOFA.

[25]  Stéphane Mallat,et al.  Characterization of Signals from Multiscale Edges , 2011, IEEE Trans. Pattern Anal. Mach. Intell..

[26]  W. Moon,et al.  Ultrasound breast tumor image computer-aided diagnosis with texture and morphological features. , 2008, Academic radiology.

[27]  V. Vijaya Kumar,et al.  Classification of Textures Based on Features Extracted from Preprocessing Images on Random Windows , 2009 .

[28]  Y. Meyer Wavelets and Operators , 1993 .

[29]  Hee Chan Kim,et al.  Computer-aided diagnosis of solid breast nodules on ultrasound with digital image processing and artificial neural network , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[30]  Sudipta Roy,et al.  A NEW HYBRID IMAGE DENOISING METHOD , 2010 .

[31]  W. Wayt Gibbs Untangling the roots of cancer. , 2003 .

[32]  Rozi Mahmud,et al.  Segmentation of masses from breast ultrasound images using parametric active contour algorithm , 2010 .

[33]  Dar-Ren Chen,et al.  Speckle reduction imaging of breast ultrasound does not improve the diagnostic performance of morphology‐based CAD System , 2012, Journal of clinical ultrasound : JCU.

[34]  Lotfi A. Zadeh,et al.  The Concepts of a Linguistic Variable and its Application to Approximate Reasoning , 1975 .

[35]  Hui Zhang,et al.  A fast texture feature extraction method for region-based image segmentation , 2005, IS&T/SPIE Electronic Imaging.

[36]  Chang Beom Ahn,et al.  Adaptive template filtering for signal-to-noise ratio enhancement in magnetic resonance imaging , 1999, IEEE Transactions on Medical Imaging.

[37]  Hamid R. Tizhoosh,et al.  Segmentation of prostate boundaries using regional contrast enhancement , 2005, IEEE International Conference on Image Processing 2005.

[38]  Nassir Navab,et al.  A State-of-the-Art Review on Segmentation Algorithms in Intravascular Ultrasound (IVUS) Images , 2012, IEEE Transactions on Information Technology in Biomedicine.

[39]  Bhabesh Deka,et al.  ULTRASOUND IMAGE SEGMENTATION USING WATERSHEDS AND REGION MERGING , 2006 .

[40]  A. Stavros,et al.  Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. , 1995, Radiology.

[41]  Hyung-Ji Lee,et al.  Computer aided diagnosis (CAD) of breast mass on ultrasonography and scintimammography , 2005, Proceedings of 7th International Workshop on Enterprise networking and Computing in Healthcare Industry, 2005. HEALTHCOM 2005..

[42]  Astha Baxi,et al.  A Review on Otsu Image Segmentation Algorithm , 2013 .

[43]  D. Ruppert The Elements of Statistical Learning: Data Mining, Inference, and Prediction , 2004 .

[44]  Thomas J. Hebert,et al.  A fully automated optimization algorithm for determining the 3-D patient contour from photo-peak projection data in SPECT , 1995, IEEE Trans. Medical Imaging.

[45]  Prabhpreet Kaur,et al.  Speckle Noise Reduction in Ultrasound Images , 2014 .

[46]  Dar-Ren Chen,et al.  Computer-aided diagnosis with textural features for breast lesions in sonograms , 2011, Comput. Medical Imaging Graph..

[47]  Y. Meyer,et al.  Wavelets and Operators: Frontmatter , 1993 .