Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure
暂无分享,去创建一个
E. Oetjen | W. Knepel | M. González | T. Quentin | U. Böer | C. Dickel | I. Cierny | W. Knepel | M. González | Thomas Quentin
[1] M. Tzvetkov,et al. A Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription , 2008, Molecular Pharmacology.
[2] S. Kahn,et al. Mechanisms linking obesity to insulin resistance and type 2 diabetes , 2006, Nature.
[3] M. Hafner,et al. Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance , 2006, Nature.
[4] A. Salehi,et al. Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations , 2006, Diabetes.
[5] C. Duve. Le lysosome a cinquante ans , 2005 .
[6] M. Oppermann,et al. G Protein-coupled Receptor Kinases Promote Phosphorylation and β-Arrestin-mediated Internalization of CCR5 Homo- and Hetero-oligomers* , 2005, Journal of Biological Chemistry.
[7] J. Olefsky,et al. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. , 2005, Molecular endocrinology.
[8] C. Duve. The lysosome turns fifty , 2005, Nature Cell Biology.
[9] O. Larsson,et al. β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase* , 2005, Journal of Biological Chemistry.
[10] O. McGuinness,et al. Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. , 2005, American journal of physiology. Endocrinology and metabolism.
[11] E. Oetjen,et al. Protein Kinase B Activity Is Sufficient to Mimic the Effect of Insulin on Glucagon Gene Transcription* , 2005, Journal of Biological Chemistry.
[12] J. Olefsky,et al. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. , 2005, Molecular endocrinology.
[13] A. Rana,et al. Peroxisome Proliferator-activated Receptor γ Activation Can Regulate β-Catenin Levels via a Proteasome-mediated and Adenomatous Polyposis Coli-independent Pathway* , 2004, Journal of Biological Chemistry.
[14] Marc Montminy,et al. TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver , 2003, Science.
[15] E. Oetjen,et al. Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice. , 2003, Molecular pharmacology.
[16] Y. Kido,et al. CEACAM1 regulates insulin clearance in liver , 2002, Nature Genetics.
[17] P. Vollenweider,et al. Insulin and Insulin-like Growth Factor I Receptors Utilize Different G Protein Signaling Components* , 2001, The Journal of Biological Chemistry.
[18] E. Oetjen,et al. Insulin Responsiveness of the Glucagon Gene Conferred by Interactions between Proximal Promoter and More Distal Enhancer-like Elements Involving the Paired-domain Transcription Factor Pax6* , 2000, The Journal of Biological Chemistry.
[19] B. Ahrén,et al. Glucose intolerance is predicted by low insulin secretion and high glucagon secretion: outcome of a prospective study in postmenopausal Caucasian women , 2000, Diabetologia.
[20] J D Veldhuis,et al. Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals. , 1999, The Journal of clinical endocrinology and metabolism.
[21] M. Bünemann,et al. G‐protein coupled receptor kinases as modulators of G‐protein signalling , 1999, The Journal of physiology.
[22] P. Bergsten,et al. Pulsatile insulin release: role of cytoplasmic Ca2+ oscillations. , 1998, Diabetes & metabolism.
[23] P. Cohen,et al. Mechanism of activation and function of protein kinase B. , 1998, Current opinion in genetics & development.
[24] I. Svendsen,et al. Evidence for a Major Role for Glucagon in Regulation of Plasma Glucose in Conscious, Nondiabetic, and Alloxan-Induced Diabetic Rabbits , 1996, Diabetes.
[25] L. Dick,et al. Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin , 1996, The Journal of Biological Chemistry.
[26] P. Lefèbvre. Glucagon and its Family Revisited , 1995, Diabetes Care.
[27] 浩一 木佐貫. Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion , 1995 .
[28] E. Oetjen,et al. Distinct properties of the cAMP-responsive element of the rat insulin I gene. , 1994, The Journal of biological chemistry.
[29] E. Oetjen,et al. Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization. , 1993, The Journal of biological chemistry.
[30] S. Bonner-Weir,et al. Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes. , 1990, The Journal of clinical investigation.
[31] J. Norton,et al. Tumor necrosis factor: immune endocrine interaction. , 1989, Surgery.
[32] J. Treadway,et al. Regulation of the insulin receptor kinase by hyperinsulinism. , 1989, The Journal of biological chemistry.
[33] J. Philippe. Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line. , 1989, The Journal of clinical investigation.
[34] A. Baron,et al. Role of Hyperglucagonemia in Maintenance of Increased Rates of Hepatic Glucose Output in Type II Diabetics , 1987, Diabetes.
[35] A. Golay,et al. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. , 1987, The Journal of clinical endocrinology and metabolism.
[36] T. Gelehrter,et al. Desensitization of hepatoma cells to insulin action. Evidence for a post-receptor mechanism. , 1981, The Journal of biological chemistry.
[37] L. Orci,et al. Glucagon and the A cell: physiology and pathophysiology (first two parts). , 1981, The New England journal of medicine.
[38] L. Orci,et al. Glucagon and the A cell: physiology and pathophysiology (second of two parts). , 1981, The New England journal of medicine.
[39] G WhittakerP,et al. 共やくエクイン・エストロゲン(Premarin)服用閉経婦人の血清エクイリン,エストロン,エストラジオール値 , 1980 .
[40] J. Olefsky,et al. Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation. , 1979, The Journal of biological chemistry.
[41] P. Bennett,et al. Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels. , 1979, The Journal of biological chemistry.
[42] W. Blackard,et al. Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer. , 1978, Endocrinology.
[43] J. Livingston,et al. Insulin-dependent regulation of the insulin-sensitivity of adipocytes , 1978, Nature.
[44] L. Orci,et al. THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS , 1975, The Lancet.