Acoustic characterization of microbubble dynamics in laser-induced optical breakdown

A real-time acoustic technique to characterize microbubbles produced by laser-induced optical breakdown (LIOB) in water was developed. Femtosecond laser pulses are focused just inside the surface of a small liquid tank. A tightly focused, high frequency, single-element ultrasonic transducer is positioned so its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a bubble forms and a pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble is actively probed with pulse-echo measurements from the same transducer. After the bubble forms, received pulse-echo signals have an extra pulse, describing the bubble location and providing a measure of axial bubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of cavitation bubbles due to optical breakdown. These same plots also can be used to quantify LIOB thresholds.

[1]  U. Parlitz,et al.  Energy balance of optical breakdown in water at nanosecond to femtosecond time scales , 1999 .

[2]  G. Mourou,et al.  Femtosecond Optical Breakdown in Dielectrics , 1998 .

[3]  Vernon L. Newhouse,et al.  Bubble size measurements using the nonlinear mixing of two frequencies , 1984 .

[4]  E. W. Meijer,et al.  About Dendrimers: Structure, Physical Properties, and Applications. , 1999, Chemical reviews.

[5]  Enhancement of laser-induced optical breakdown using metal/dendrimer nanocomposites , 2002 .

[6]  D. Miller,et al.  Photodisruptive laser nucleation of ultrasonic cavitation for biomedical applications. , 2001, Journal of biomedical optics.

[7]  T. Leighton.  5 – Effects and Mechanisms , 1994 .

[8]  G. Gibson,et al.  ULTRAFAST ELECTRON DYNAMICS IN FEMTOSECOND OPTICAL BREAKDOWN OF DIELECTRICS , 1999 .

[9]  E. Mazur,et al.  Dynamics of femtosecond laser-induced breakdown in water from femtoseconds to microseconds. , 2002, Optics express.

[10]  S. Kaul,et al.  Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. , 2000, Circulation.

[11]  Eric Mazur,et al.  Thresholds for femtosecond laser-induced breakdown in bulk transparent solids and water , 1998, Optics & Photonics.

[12]  J. P. Callan,et al.  Three-dimensional optical storage inside transparent materials. , 1996, Optics letters.

[13]  R. Ispasoiu,et al.  Large Optical Limiting from Novel Metal-Dendrimer Nanocomposite Materials , 2000 .

[14]  K W Ferrara,et al.  Optical and acoustical dynamics of microbubble contrast agents inside neutrophils. , 2001, Biophysical journal.

[15]  Costas P. Grigoropoulos,et al.  Pulsed laser-induced ablation of absorbing liquids and acoustic-transient generation , 1998 .

[16]  G. Mourou,et al.  Laser ablation and micromachining with ultrashort laser pulses , 1997 .

[17]  D. Miller,et al.  Ultrasonic detection of resonant cavitation bubbles in a flow tube by their second-harmonic emissions , 1981 .

[18]  M. O’Donnell,et al.  Acoustic detection of microbubble formation in enhanced optical breakdown of silver/dendrimer nanocomposites , 2003, Conference on Lasers and Electro-Optics, 2003. CLEO '03..

[19]  Josef F. Bille,et al.  Laser-induced optical breakdown on hard and soft tissues and its dependence on the pulse duration: experiment and model , 1996 .

[20]  Perry,et al.  Nanosecond-to-femtosecond laser-induced breakdown in dielectrics. , 1996, Physical review. B, Condensed matter.

[21]  Nico de Jong,et al.  SCATTERING PROPERTIES OF ENCAPSULATED GAS BUBBLES AT HIGH ULTRASOUND PRESSURES , 1999 .

[22]  E. Mazur,et al.  Minimally disruptive laser-induced breakdown in water. , 1997 .

[23]  T. Leighton.  The Acoustic Bubble , 1994 .

[24]  G. Mourou,et al.  Corneal refractive surgery with femtosecond lasers , 1999 .