Interdigital sensing system for detection of levels of creatinine from the samples

Creatinine is a biological waste that is diffused in the blood and filtered by the kidneys to reduce blood waste content-oriented toxicity for maintaining homeostasis in the living body. In the current research, we have developed a sensing system for early detection of side effects of brain cancer chemotherapy on human kidneys by monitoring the rise in creatinine levels. High creatinine levels can lead to permanent incurable conditions such as acute kidney damage or acute kidney failure. The proposed research is related to the real-time detection of creatinine in an aqueous medium. The sensing system is able to determine concentrations within the range of 0.1 – 50 ppm. The sensitivity % curve presented aids in finding an unknown sample concentration from resistance values at a frequency of 100 Hz using the electrical impedance spectroscopy (EIS) technique. The results highlight the future possibility of modifying this system for early levels of creatinine rise for preventing life-threatening conditions and providing indications to doctors in the form of parts per million (ppm) unit results where they can change the chemotherapy medicines or reduce the total drug regiments.

[1]  E. Noiri,et al.  Acute Kidney Injury: Transition to Chronic Kidney Disease , 2019, Human Pathobiochemistry.

[2]  B. Afşar,et al.  Hyperthermic intraperitonal chemotherapy is an independent risk factor for development of acute kidney injury. , 2018, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[3]  Mike Hernandez,et al.  Identification of risk factors associated with postoperative acute kidney injury after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a retrospective study , 2018, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[4]  Mandel,et al.  Hyperthermic intraperitoneal chemotherapy is an independent risk factor for development of acute kidney injury , 2018 .

[5]  M. Perazella,et al.  Anticancer Drug-Induced Acute Kidney Injury , 2017, Kidney international reports.

[6]  S. Goldstein,et al.  Drug-Induced Acute Kidney Injury: A Focus on Risk Assessment for Prevention. , 2015, Critical care clinics.

[7]  M. Perazella,et al.  Drug-induced glomerular disease: attention required! , 2015, Clinical journal of the American Society of Nephrology : CJASN.

[8]  A. Shirali,et al.  Drug-induced impairment of renal function , 2014, International journal of nephrology and renovascular disease.

[9]  Chinthaka P. Gooneratne,et al.  Introducing molecular selectivity in rapid impedimetric sensing of phthalates , 2014, 2014 IEEE International Instrumentation and Measurement Technology Conference (I2MTC) Proceedings.

[10]  J. Kosel,et al.  Selective Manipulation of Superparamagnetic Beads by a Magnetic Microchip , 2013, IEEE Transactions on Magnetics.

[11]  M. Aapro,et al.  Importance of monitoring renal function in patients with cancer. , 2012, Cancer treatment reviews.

[12]  D. Choudhury,et al.  Chemotherapy-associated renal dysfunction , 2009, Nature Reviews Nephrology.

[13]  M. Kris,et al.  Gemcitabine nephrotoxicity and hemolytic uremic syndrome: report of 29 cases from a single institution. , 2009, Clinical nephrology.

[14]  S. Oudard,et al.  Prevalence of Renal Insufficiency in cancer patients and implications for anticancer drug management , 2007, Cancer.

[15]  P. Kintzel.  Anticancer Drug—Induced Kidney Disorders , 2001, Drug safety.