Stacking of a benzenehexacarboxylic acid core in the crystal structure of benzenehexacarboxylic acid α-aminomethyl isobutyrate amide (MA-Aib6)–sodium nitrate complex

MA-Aib6 forms discrete stacks with sandwiched water, sodium and nitrate ions, presenting a novel profile, where nine out of the 12 binding sites, of the six amides present, are involved in bonding with water, sodium and nitrate ions, with no inter-amide hydrogen bonding. This is the first example of the stacking of a benzenehexacarboxylic acid core.

[1]  I. Karle.  Aspects of Peptide Folding and Aggregation , 1999 .

[2]  I. Guzei,et al.  Syntheses and structures of Group 1 mellitate compounds, K6[C6(COO)6] · 8H2O and Cs5[C6(COO)6H] · 7H2O , 1999 .

[3]  Horst Kessler,et al.  Stereoisomeric Peptide Libraries and Peptidomimetics for Designing Selective Inhibitors of the αvβ3 Integrin for a New Cancer Therapy , 1997 .

[4]  G. Müller.  The β Turn as a Selectivity Switch: βI or βII′? That Is the Question , 1996 .

[5]  M. Maekawa,et al.  SYNTHESIS AND STRUCTURE OF A THREE-DIMENSIONAL LANTHANUM(III) COORDINATION POLYMER WITH MELLITATE, {La2[C6(COO)6](H2O)9} · 2H2O , 1996 .

[6]  Joel P. Schneider,et al.  Templates That Induce .alpha.-Helical, .beta.-Sheet, and Loop Conformations , 1995 .

[7]  Joseph M. Salvino,et al.  De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing beta-D-glucose as a novel scaffolding , 1993 .

[8]  W. Shakespeare,et al.  The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold. , 1993 .

[9]  W. Shakespeare,et al.  The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands , 1992 .

[10]  R. Hirschmann.  Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research , 1991 .

[11]  W. Kuhs,et al.  A neutron diffraction study on hydrogen bonding in the mineral mellite (Al2[C6(COO)6] · 16H2O) at 15 K , 1991 .

[12]  I. Karle.  The conformation of the sodium complex of a biologically active analog of antamanide in the crystalline state. , 1974, Biochemistry.

[13]  S. Darlow.  The crystal structure of mellitic acid (benzenehexacarboxylic acid) , 1961 .

[14]  S. Darlow.  Crystal Structure of Mellitic Acid , 1960 .

[15]  A. Bezjak,et al.  Crystal Structure of Mellitic Acid , 1960, Nature.