Regulatory T cells in transplantation.

[1]  D. Zélénika,et al.  Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms , 2003, Immunological reviews.

[2]  R. Lechler,et al.  Immunologic monitoring , 2003, Immunological reviews.

[3]  H. Aburatani,et al.  Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade. , 2003, Physiological genomics.

[4]  U. Grohmann,et al.  Modulation of tryptophan catabolism by regulatory T cells , 2003, Nature Immunology.

[5]  G. Opelz,et al.  Serial Peripheral Blood Perforin and Granzyme B Gene Expression Measurements for Prediction of Acute Rejection in Kidney Graft Recipients , 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[6]  C. Mathieu,et al.  Regulatory cell-mediated tolerance does not protect against chronic rejection , 2003, Transplantation.

[7]  M. Sarwal,et al.  Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. , 2003, The New England journal of medicine.

[8]  E. Wherry,et al.  Heterologous immunity provides a potent barrier to transplantation tolerance. , 2003, The Journal of clinical investigation.

[9]  A. Scherer,et al.  Early prognosis of the development of renal chronic allograft rejection by gene expression profiling of human protocol biopsies , 2003, Transplantation.

[10]  J. Dennis,et al.  UDP-N-acetylglucosamine:α-6-d-mannoside β1,6 N-acetylglucosaminyltransferase V (Mgat5) deficient mice , 2002 .

[11]  H. Waldmann,et al.  Dominant transplantation tolerance impairs CD8+ T cell function but not expansion , 2002, Nature Immunology.

[12]  K. Wood,et al.  Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy1 , 2002, The Journal of Immunology.

[13]  U. Grohmann,et al.  CTLA-4–Ig regulates tryptophan catabolism in vivo , 2002, Nature Immunology.

[14]  A. Gaber,et al.  Quantitative detection of T-cell activation markers by real-time PCR in renal transplant rejection and correlation with histopathologic evaluation1 , 2002, Transplantation.

[15]  Gerhard Opelz,et al.  Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells , 2002, The Journal of experimental medicine.

[16]  A. Valujskikh,et al.  Primed Allospecific T Cells Prevent the Effects of Costimulatory Blockade on Prolonged Cardiac Allograft Survival in Mice , 2002, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[17]  Akemi Sakamoto,et al.  CD25+CD4+ T cells contribute to the control of memory CD8+ T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Sprent,et al.  Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells , 2002, The Journal of experimental medicine.

[19]  J. Miyazaki,et al.  Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression1 , 2002, The Journal of Immunology.

[20]  D. Keskin,et al.  Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses1 , 2002, The Journal of Immunology.

[21]  M. Gilliet,et al.  Generation of Human CD8 T Regulatory Cells by CD40 Ligand–activated Plasmacytoid Dendritic Cells , 2002, The Journal of experimental medicine.

[22]  David F. Richards,et al.  In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.

[23]  M. Goldman,et al.  Analysis of spontaneous mRNA cytokine production in peripheral blood. , 2002, Journal of immunological methods.

[24]  A. Krasinskas,et al.  Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of allorecognition , 2002, Nature Medicine.

[25]  T. Strom,et al.  Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance1 , 2002, The Journal of Immunology.

[26]  M. Colonna,et al.  Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4 , 2002, Nature Immunology.

[27]  Tomohiro Watanabe,et al.  Administration of an Antigen at a High Dose Generates Regulatory CD4+ T Cells Expressing CD95 Ligand and Secreting IL-4 in the Liver1 , 2002, The Journal of Immunology.

[28]  D. Hudrisier,et al.  Preferential Recognition of Self Antigens Despite Normal Thymic Deletion of CD4+CD25+ Regulatory T Cells1 , 2002, The Journal of Immunology.

[29]  H. Grey,et al.  Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[30]  D. Zélénika,et al.  Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts1 , 2002, The Journal of Immunology.

[31]  J. Shimizu,et al.  Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance , 2002, Nature Immunology.

[32]  M. Papiernik,et al.  Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10. , 2002, International immunology.

[33]  M. Karim,et al.  CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1 , 2002, The Journal of Immunology.

[34]  G. Lombardi,et al.  Human Anergic CD4+ T Cells Can Act as Suppressor Cells by Affecting Autologous Dendritic Cell Conditioning and Survival1 , 2002, The Journal of Immunology.

[35]  M. Byrne,et al.  CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. , 2002, Immunity.

[36]  M. Taniguchi,et al.  CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms. , 2002, Blood.

[37]  L. Ignatowicz,et al.  Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells , 2002, The Journal of Immunology.

[38]  Varuna Aluvihare,et al.  B cells and professional APCs recruit regulatory T cells via CCL4 , 2001, Nature Immunology.

[39]  T. Strom,et al.  Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantation. , 2001, Transplantation.

[40]  P. Neuhaus,et al.  Influence of donor brain death on chronic rejection of renal transplants in rats. , 2001, Journal of the American Society of Nephrology : JASN.

[41]  C. Orosz,et al.  Murine Renal Allografts: Spontaneous Acceptance Is Associated with Regulated T Cell-Mediated Immunity1 , 2001, The Journal of Immunology.

[42]  H. Volk,et al.  T Cell Subsets and In Vitro Immune Regulation in “Infectious” Transplantation Tolerance1 , 2001, The Journal of Immunology.

[43]  R. Lechler,et al.  Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. , 2001, Blood.

[44]  H. Weiner,et al.  Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration1 , 2001, The Journal of Immunology.

[45]  P. Nickel,et al.  Cytotoxic effector molecule gene expression in acute renal allograft rejection: correlation with clinical outcome; histopathology and function of the allograft. , 2001, Transplantation.

[46]  A. Iellem,et al.  Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells , 2001, The Journal of experimental medicine.

[47]  C. Larsen,et al.  Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology. , 2001, Transplantation.

[48]  H. Groux,et al.  Differentiation of Regulatory T Cells 1 Is Induced by CD2 Costimulation1 , 2001, The Journal of Immunology.

[49]  W. Strober,et al.  Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β , 2001, The Journal of experimental medicine.

[50]  T. Laufer,et al.  Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells , 2001, The Journal of experimental medicine.

[51]  L. Adorini,et al.  Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 , 2001, The Journal of Immunology.

[52]  E. Shevach,et al.  Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells , 2001, The Journal of Immunology.

[53]  G. Freeman,et al.  CD4+CD25high Regulatory Cells in Human Peripheral Blood1 , 2001, The Journal of Immunology.

[54]  P. Rutgeerts,et al.  B7 Interactions with CD28 and CTLA-4 Control Tolerance or Induction of Mucosal Inflammation in Chronic Experimental Colitis1 , 2001, The Journal of Immunology.

[55]  K. Namba,et al.  In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha‐melanocyte stimulating hormone (α‐MSH) , 2001, Immunology and cell biology.

[56]  H. Aburatani,et al.  A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis. , 2001, Transplantation.

[57]  T. Sugie,et al.  Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[58]  H. Groux,et al.  Regulation of TGF-β Response During T Cell Activation Is Modulated by IL-101 , 2001, The Journal of Immunology.

[59]  A. Stadnyk,et al.  Oral Exposure to Alloantigen Generates Intragraft CD8+ Regulatory Cells1 , 2001, The Journal of Immunology.

[60]  A. Khoruts,et al.  Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen1 , 2001, The Journal of Immunology.

[61]  S. Yamagiwa,et al.  A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood1 , 2001, The Journal of Immunology.

[62]  G. Schuler,et al.  Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood , 2001, The Journal of experimental medicine.

[63]  M. Roncarolo,et al.  Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function , 2001, The Journal of experimental medicine.

[64]  A. Enk,et al.  Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood , 2001, The Journal of experimental medicine.

[65]  R. de Waal Malefyt,et al.  IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells1 , 2001, The Journal of Immunology.

[66]  M. Salmon,et al.  Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis‐prone population , 2001, European journal of immunology.

[67]  A. Naji,et al.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[68]  D. Mason,et al.  Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro , 2001, European journal of immunology.

[69]  M. Suthanthiran,et al.  Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. , 2001, The New England journal of medicine.

[70]  J. Soulillou,et al.  Immune monitoring for rejection of kidney transplants. , 2001, The New England journal of medicine.

[71]  F. Powrie,et al.  IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1 , 2001, The Journal of Immunology.

[72]  J. Dennis,et al.  Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation , 2001, Nature.

[73]  R. Lechler,et al.  Anergic T Cells Inhibit the Antigen-Presenting Function of Dendritic Cells1 , 2000, The Journal of Immunology.

[74]  J. Shimizu,et al.  Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. , 2000, International immunology.

[75]  T. Mak,et al.  Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4 , 2000, The Journal of experimental medicine.

[76]  Fiona Powrie,et al.  Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation , 2000, The Journal of experimental medicine.

[77]  W. Strober,et al.  Activated Self-MHC-Reactive T Cells Have the Cytokine Phenotype of Th3/T Regulatory Cell 1 T Cells , 2000, The Journal of Immunology.

[78]  Li Zhang,et al.  Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression , 2000, Nature Medicine.

[79]  H. Hall,et al.  CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells , 2000, European journal of immunology.

[80]  C. Akdis,et al.  IL‐10 directly acts on T cells by specifically altering the CD28 co‐stimulation pathway , 2000, European journal of immunology.

[81]  A. Cumano,et al.  Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment1 , 2000, The Journal of Immunology.

[82]  J. Bluestone,et al.  B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.

[83]  C. Piccirillo,et al.  The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases. , 2000, Journal of autoimmunity.

[84]  Ethan M. Shevach,et al.  Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific , 2000, The Journal of Immunology.

[85]  E. Field,et al.  CD4+CD25+ cells regulate CD8 cell anergy in neonatal tolerant mice. , 1999, Transplantation.

[86]  T. Strom,et al.  Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance , 1999, Nature Medicine.

[87]  Fiona Powrie,et al.  An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation , 1999, The Journal of experimental medicine.

[88]  F. Shi,et al.  Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells. , 1999, Journal of immunology.

[89]  F. Otsuka,et al.  Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. , 1999, Journal of immunology.

[90]  D. Mason,et al.  Regulatory T Cells in the Control of Autoimmunity: the Essential Role of  Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes , 1999, The Journal of experimental medicine.

[91]  M. Toda,et al.  Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. , 1998, International immunology.

[92]  S. Ménoret,et al.  A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. , 1998, The Journal of clinical investigation.

[93]  G. Pennesi,et al.  Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+CD28- regulatory T cells. , 1998, Journal of immunology.

[94]  H. Weiner,et al.  IL‐4 is a differentiation factor for transforming growth factor‐β secreting Th3 cells and oral administration of IL‐4 enhances oral tolerance in experimental allergic encephalomyelitis , 1998, European journal of immunology.

[95]  E. Shevach,et al.  CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production , 1998, The Journal of experimental medicine.

[96]  R. Noelle,et al.  Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. , 1998, The Journal of clinical investigation.

[97]  P. Linsley,et al.  IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. , 1998, Journal of immunology.

[98]  A. O’Garra,et al.  Cytokines induce the development of functionally heterogeneous T helper cell subsets. , 1998, Immunity.

[99]  E. Shevach,et al.  CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. , 1998, Journal of immunology.

[100]  D. Sachs,et al.  Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity. , 1997, Transplantation.

[101]  Hervé Groux,et al.  A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.

[102]  J. Allison,et al.  The emerging role of CTLA-4 as an immune attenuator. , 1997, Immunity.

[103]  Fadi G Lakkis,et al.  Acute rejection of vascularized heart allografts in the absence of IFNgamma. , 1996, Transplantation.

[104]  K. Wood,et al.  Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients. , 1996, Transplantation.

[105]  S. Sakaguchi,et al.  Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation , 1996, The Journal of experimental medicine.

[106]  T. Strom,et al.  The intragraft gene activation of markers reflecting T-cell-activation and -cytotoxicity analyzed by quantitative RT-PCR in renal transplantation. , 1996, Clinical nephrology.

[107]  H. Weiner,et al.  Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. , 1996, The Journal of clinical investigation.

[108]  R. Coffman,et al.  A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells , 1996, The Journal of experimental medicine.

[109]  C. Janeway,et al.  Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[110]  H. Maeda,et al.  TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice. , 1995, Journal of immunology.

[111]  H. Griesser,et al.  Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4 , 1995, Science.

[112]  K. Wood,et al.  Transplantation tolerance induced by antigen pretreatment and depleting anti‐CD4 antibody depends on CD4+ T cell regulation during the induction phase of the response , 1995, European journal of immunology.

[113]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[114]  P. Linsley,et al.  CTLA-4 can function as a negative regulator of T cell activation. , 1994, Immunity.

[115]  R. Coffman,et al.  Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell- mediated immunity , 1994, The Journal of experimental medicine.

[116]  P. Linsley,et al.  IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. , 1993, Journal of immunology.

[117]  J. Watson,et al.  CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells , 1993, The Journal of experimental medicine.

[118]  S. Gupta,et al.  Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and -alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factor. , 1993, The Journal of biological chemistry.

[119]  D. Kioussis,et al.  "Infectious" transplantation tolerance , 1993, Science.

[120]  B. Hall,et al.  Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action , 1990, The Journal of experimental medicine.

[121]  T. Gajewski,et al.  Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. , 1988, Journal of immunology.

[122]  A. Billiau,et al.  Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. , 1988, Journal of Immunology.

[123]  R. Gershon,et al.  Infectious immunological tolerance. , 1971, Immunology.

[124]  P. Medawar,et al.  Quantitative Studies on Tissue Transplantation Immunity. III. Actively Acquired Tolerance , 1956, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[125]  P. Medawar,et al.  ‘Actively Acquired Tolerance’ of Foreign Cells , 1953, Nature.

[126]  H. Nariuchi,et al.  Effect of inhibitors of glycoprotein processing on cytokine secretion and production in anti CD3-stimulated T cells. , 2000, Biological & pharmaceutical bulletin.

[127]  C. Pénit,et al.  Regulatory Cd4 T Cells: Expression of Il-2rα Chain, Resistance to Clonal Deletion and Il-2 Dependency , 1998 .

[128]  H. Waldmann,et al.  Brief Definitive Report Identification of Regulatory T Cells in Tolerated Allografts , 2022 .