New Insights into the Pharmacology of Dexmedetomidine and Open Issues for Neurosurgical Procedures

[1]  M. Fiore,et al.  Dexmedetomidine as adjunctive therapy for the treatment of alcohol withdrawal syndrome , 2019, JBI Database of Systematic Reviews and Implementation Reports.

[2]  M. Fiore,et al.  Dexmedetomidine in the Management of Awake Fiberoptic Intubation , 2019, The Open Anesthesia Journal.

[3]  W. Stummer,et al.  Conscious sedation with dexmedetomidine compared with asleep-awake-asleep craniotomies in glioma surgery: an analysis of 180 patients. , 2018, Journal of neurosurgery.

[4]  Min Zhang,et al.  Pharmacokinetics of dexmedetomidine administered to patients with end‐stage renal failure and secondary hyperparathyroidism undergoing general anaesthesia , 2018, Journal of clinical pharmacy and therapeutics.

[5]  M. Cascella,et al.  The role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction , 2017, Neural regeneration research.

[6]  A. Quiñones‐Hinojosa,et al.  Awake craniotomy anesthesia : A comparison between the monitored 1 anesthesia care versus the asleep-awake-asleep technique , 2017 .

[7]  R. Surve,et al.  Use of Dexmedetomidine Along With Local Infiltration Versus General Anesthesia for Burr Hole and Evacuation of Chronic Subdural Hematoma (CSDH) , 2017, Journal of neurosurgical anesthesiology.

[8]  Abd-Elazeem Elbakry,et al.  Propofol-dexmedetomidine versus propofol-remifentanil conscious sedation for awake craniotomy during epilepsy surgery. , 2017, Minerva anestesiologica.

[9]  M. Cascella,et al.  Anesthetic dreaming, anesthesia awareness and patient satisfaction after deep sedation with propofol target controlled infusion: A prospective cohort study of patients undergoing day case breast surgery , 2017, Oncotarget.

[10]  M. Cascella,et al.  Anesthetic dreaming, anesthesia awareness and patient satisfaction after deep sedation with propofol target controlled infusion: A prospective cohort study of patients undergoing day case breast surgery , 2017, Oncotarget.

[11]  M. Berger,et al.  Anesthesia for awake craniotomy: a how-to guide for the occasional practitioner , 2017, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

[12]  M. Struys,et al.  Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine , 2017, Clinical Pharmacokinetics.

[13]  Chunguang Ren,et al.  The Safety and Efficacy of Dexmedetomidine vs. Sufentanil in Monitored Anesthesia Care during Burr-Hole Surgery for Chronic Subdural Hematoma: A Retrospective Clinical Trial , 2016, Front. Pharmacol..

[14]  D. Sessler,et al.  The Effects of Dexmedetomidine and Remifentanil on Hemodynamic Stability and Analgesic Requirement After Craniotomy: A Randomized Controlled Trial , 2016, Journal of neurosurgical anesthesiology.

[15]  Xiahong Luo,et al.  Protective effects of dexmedetomidine on brain function of glioma patients undergoing craniotomy resection and its underlying mechanism , 2016, Clinical Neurology and Neurosurgery.

[16]  M. Bernstein,et al.  Dexmedetomidine vs propofol-remifentanil conscious sedation for awake craniotomy: a prospective randomized controlled trial. , 2016, British journal of anaesthesia.

[17]  S. Choi,et al.  Comparison of Dexmedetomidine and Remifentanil on Airway Reflex and Hemodynamic Changes during Recovery after Craniotomy , 2016, Yonsei medical journal.

[18]  V. Bishnoi,et al.  Comparison of Dexmedetomidine Versus Midazolam-Fentanyl Combination for Monitored Anesthesia Care During Burr-Hole Surgery for Chronic Subdural Hematoma , 2016, Journal of neurosurgical anesthesiology.

[19]  M. Irwin,et al.  A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops , 2016, Anaesthesia.

[20]  A. Gelb,et al.  Mild Sedation Exacerbates or Unmasks Focal Neurologic Dysfunction in Neurosurgical Patients with Supratentorial Brain Mass Lesions in a Drug-specific Manner , 2016, Anesthesiology.

[21]  E. Park,et al.  Comparison of remifentanil with dexmedetomidine for monitored anaesthesia care in elderly patients during vertebroplasty and kyphoplasty , 2016, The Journal of international medical research.

[22]  Zhengyu He,et al.  Effects of mild hypoalbuminemia on the pharmacokinetics and pharmacodynamics of dexmedetomidine in patients after major abdominal or thoracic surgery. , 2015, Journal of clinical anesthesia.

[23]  Y. Oh,et al.  Echocardiographic evaluation of the effects of dexmedetomidine on cardiac function during total intravenous anaesthesia , 2015, Anaesthesia.

[24]  Ke Peng,et al.  Effect of Intraoperative Dexmedetomidine on Post-Craniotomy Pain. , 2015, Clinical therapeutics.

[25]  Jing-jing Hao,et al.  Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients With Delayed Extubation After Craniotomy: A Randomized Controlled Trial , 2015, Journal of neurosurgical anesthesiology.

[26]  Edward C. Harding,et al.  Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists , 2015, Nature Neuroscience.

[27]  Sanjay Kumar,et al.  Comparison of dexmedetomidine, propofol and midazolam for short-term sedation in postoperatively mechanically ventilated neurosurgical patients , 2014, Journal of Neuroanaesthesiology and Critical Care.

[28]  T. Minami,et al.  [Gasserian ganglion block for trigeminal neuralgia under dexmedetomidine sedation]. , 2014, Masui. The Japanese journal of anesthesiology.

[29]  C. Mazer,et al.  Anesthetic Approach to High-Risk Patients and Prolonged Awake Craniotomy Using Dexmedetomidine and Scalp Block , 2014, Journal of neurosurgical anesthesiology.

[30]  G. Phillips,et al.  A Comparison of Severe Hemodynamic Disturbances Between Dexmedetomidine and Propofol for Sedation in Neurocritical Care Patients , 2014, Critical care medicine.

[31]  Aizhong Wang,et al.  Effects of dexmedetomidine on cerebral blood flow in critically ill patients with or without traumatic brain injury: A prospective controlled trial , 2013, Brain injury.

[32]  T. Sarapohja,et al.  Population Pharmacokinetics of Dexmedetomidine in Critically Ill Patients , 2013, Clinical Drug Investigation.

[33]  D. Doyle,et al.  The use of dexmedetomidine in anesthesia and intensive care: a review. , 2012, Current pharmaceutical design.

[34]  M. Mirski,et al.  'Cooperative sedation': optimizing comfort while maximizing systemic and neurological function , 2012, Critical Care.

[35]  V. Moitra,et al.  Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral Mu antagonists. , 2011, Anesthesiology clinics.

[36]  T. Iirola,et al.  Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients , 2011, Critical care.

[37]  T. Sakaki,et al.  Post-Operative Dexmedetomidine-Based Sedation After Uneventful Intracranial Surgery for Unruptured Cerebral Aneurysm: Comparison with Propofol-Based Sedation , 2011, Neurocritical care.

[38]  R. Aantaa,et al.  Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study. , 2006, British journal of anaesthesia.

[39]  A. Ho,et al.  Central apnoea after balanced general anaesthesia that included dexmedetomidine. , 2005, British journal of anaesthesia.

[40]  Kerri M. Robertson,et al.  Dexmedetomidine Pharmacodynamics: Part II: Crossover Comparison of the Analgesic Effect of Dexmedetomidine and Remifentanil in Healthy Volunteers , 2004, Anesthesiology.

[41]  M. Davies,et al.  Comparative Analgesic and Mental Effects of Increasing Plasma Concentrations of Dexmedetomidine and Alfentanil in Humans , 2004, Anesthesiology.

[42]  Y. Shehabi,et al.  Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects , 2004, Intensive Care Medicine.

[43]  H. Scheinin,et al.  Bioavailability of dexmedetomidine after extravascular doses in healthy subjects. , 2003, British journal of clinical pharmacology.

[44]  P. Talke,et al.  Systemically Administered &agr;2-Agonist-induced Peripheral Vasoconstriction in Humans , 2003, Anesthesiology.

[45]  Jun Lu,et al.  The &agr;2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects , 2003, Anesthesiology.

[46]  C. Sessler,et al.  The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. , 2002, American journal of respiratory and critical care medicine.

[47]  Leanne Groban,et al.  Dexmedetomidine-Induced Sedation in Volunteers Decreases Regional and Global Cerebral Blood Flow , 2002, Anesthesia and analgesia.

[48]  R. Venn,et al.  Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care 2 , 2022 .

[49]  Judith E. Hall,et al.  The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans , 2000, Anesthesiology.

[50]  M. Maze,et al.  Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans , 2000 .

[51]  R. Lal,et al.  Influence of cardiac output on dexmedetomidine pharmacokinetics. , 2000, Journal of pharmaceutical sciences.

[52]  B. C. Bloor,et al.  Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. , 1992, Anesthesiology.

[53]  J. Savola,et al.  Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. , 1988, European journal of pharmacology.

[54]  Jason Y. Adams,et al.  Dexmedetomidine for Refractory Intracranial Hypertension , 2019, Journal of intensive care medicine.

[55]  Ke Peng,et al.  Dexmedetomidine-fentanyl Compared With Midazolam-fentanyl for Conscious Sedation in Patients Undergoing Lumbar Disc Surgery. , 2016, Clinical therapeutics.

[56]  Z. Zuo,et al.  Dexmedetomidine-induced neuroprotection: is it translational? , 2016, Translational perioperative and pain medicine.

[57]  S. Ghosh,et al.  Monitored anesthesia care : An overview , 2022 .