Aerosol deposition in the lungs of spontaneously breathing rats using Gd‐DOTA‐based contrast agents and ultra‐short echo time MRI at 1.5 Tesla

Aerosol toxicology and drug delivery through the lungs, which depend on various parameters, require methods to quantify particle deposition. Intrapulmonary‐administered MRI contrast agent combined with lung‐specific imaging sequences has been proposed as a high performance technique for aerosol research. Here, aerosol deposition is assessed using ultra‐short echo (UTE) sequences.

[1]  Douglas R. Worsnop,et al.  Particle Morphology and Density Characterization by Combined Mobility and Aerodynamic Diameter Measurements. Part 1: Theory , 2004 .

[2]  T. Martonen Deposition patterns of cigarette smoke in human airways. , 1992, American Industrial Hygiene Association journal.

[3]  J. Patton,et al.  The lungs as a portal of entry for systemic drug delivery. , 2004, Proceedings of the American Thoracic Society.

[4]  C. Berkland,et al.  Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. , 2010, International journal of pharmaceutics.

[5]  Gerhard Adam,et al.  Clinical Safety and Diagnostic Value of the Gadolinium Chelate Gadoterate Meglumine (Gd-DOTA) , 2007, Investigative radiology.

[6]  R. Brasch,et al.  Safety aspects and pharmacokinetics of inhaled aerosolized gadolinium , 1993, Journal of magnetic resonance imaging : JMRI.

[7]  M. Moseley,et al.  Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion. , 1992, Radiology.

[8]  D. McRobbie,et al.  In vivo-in vitro correlations: predicting pulmonary drug deposition from pharmaceutical aerosols. , 2010, Journal of aerosol medicine and pulmonary drug delivery.

[9]  C Kleinstreuer,et al.  Targeted drug-aerosol delivery in the human respiratory system. , 2008, Annual review of biomedical engineering.

[10]  W. De Backer,et al.  Study of the Variability in Upper and Lower Airway Morphology in Sprague–Dawley Rats Using Modern Micro‐CT Scan‐Based Segmentation Techniques , 2009, Anatomical record.

[11]  Yannick Crémillieux,et al.  Aerosols and gaseous contrast agents for magnetic resonance imaging of the lung. , 2008, Contrast media & molecular imaging.

[12]  Comparison of aerosolized gadoteridol and gadopentetate dimeglumine for magnetic resonance ventilation imaging of the lung , 2001, Magnetic resonance in medicine.

[13]  W. Hirsch,et al.  Pulmonary resorption of inhaled gadobutrol in an animal model: usage to determine lung diffusion in MRI examinations. , 2004, Magnetic resonance imaging.

[14]  A. Roch,et al.  Magnetic resonance relaxation properties of superparamagnetic particles. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[15]  W. Kreyling,et al.  Corrections in dose assessment of 99mTc radiolabeled aerosol particles targeted to central human airways using planar gamma camera imaging. , 2009, Journal of aerosol medicine and pulmonary drug delivery.

[16]  P. Hockings,et al.  Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single‐point imaging , 2007, Journal of magnetic resonance imaging : JMRI.

[17]  Yoshiharu Ohno,et al.  Ultra‐short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice , 2010, Journal of magnetic resonance imaging : JMRI.

[18]  Richard B Thompson,et al.  MRI measurement of regional lung deposition in mice exposed nose-only to nebulized superparamagnetic iron oxide nanoparticles. , 2008, Journal of aerosol medicine and pulmonary drug delivery.

[19]  P. Burgel,et al.  Plugging (publicising) to prevent mucous plugging , 2010, European Respiratory Journal.

[20]  R. Lizio,et al.  Oral endotracheal intubation of rats for intratracheal instillation and aerosol drug delivery , 2001, Laboratory animals.

[21]  A. Marsden,et al.  Rat airway morphometry measured from in situ MRI-based geometric models. , 2012, Journal of applied physiology.

[22]  Thomas Heistracher,et al.  Local particle deposition patterns may play a key role in the development of lung cancer. , 2003, Journal of applied physiology.

[23]  R M Weisskoff,et al.  Water diffusion and exchange as they influence contrast enhancement , 1997, Journal of magnetic resonance imaging : JMRI.

[24]  S. Jain,et al.  Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation , 2004 .

[25]  S. Lehnert,et al.  Lung density changes observed in vivo in rat lungs after irradiation: variations among and within individual lungs. , 1989, International journal of radiation oncology, biology, physics.

[27]  C. Ehrhardt,et al.  Manganese: a new contrast agent for lung imaging? , 2012, Contrast media & molecular imaging.

[28]  M. O'Doherty,et al.  Pulmonary technetium-99m diethylene triamine penta-acetic acid aerosol clearance as an index of lung injury , 2005, European Journal of Nuclear Medicine.

[29]  K. Suga,et al.  Altered clearance of gadolinium diethylenetriaminepentaacetic acid aerosol from bleomycin-injured dog lungs: initial observations. , 2003, American journal of respiratory and critical care medicine.

[30]  Cory Berkland,et al.  Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization. , 2010, Molecular pharmaceutics.

[31]  Alison L. Marsden,et al.  Airflow and Particle Deposition Simulations in Health and Emphysema: From In Vivo to In Silico Animal Experiments , 2014, Annals of Biomedical Engineering.

[32]  Sam T. S. Wong,et al.  A strategy for sampling on a sphere applied to 3D selective RF pulse design , 1994, Magnetic resonance in medicine.

[33]  H. Alsaid,et al.  Longitudinal 3He and proton imaging of magnetite biodistribution in a rat model of instilled nanoparticles , 2008, Magnetic resonance in medicine.

[34]  N J Pelc,et al.  Rapid calculation of T1 using variable flip angle gradient refocused imaging. , 1987, Magnetic resonance imaging.

[35]  J. Mintorovitch,et al.  Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths , 2005, Investigative radiology.

[36]  Stefan Eberl,et al.  Aerosol deposition and clearance measurement: a novel technique using dynamic SPET , 2001, European Journal of Nuclear Medicine.

[37]  J. Murray,et al.  Aerosolized gadolinium-DTPA enhances the magnetic resonance signal of extravascular lung water. , 1987, Investigative radiology.

[38]  Bo Olsson,et al.  Pulmonary Drug Metabolism, Clearance, and Absorption , 2011 .

[39]  Yannick Crémillieux,et al.  Contrast enhanced lung MRI in mice using ultra‐short echo time radial imaging and intratracheally administrated Gd‐DOTA‐based nanoparticles , 2013, Magnetic resonance in medicine.

[40]  J. Heyder,et al.  Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. , 2004, Proceedings of the American Thoracic Society.

[41]  G. Guillot,et al.  Magnetic susceptibility matching at the air–tissue interface in rat lung by using a superparamagnetic intravascular contrast agent: Influence on transverse relaxation time of hyperpolarized helium‐3 , 2005, Magnetic resonance in medicine.

[42]  Jeffrey C. Lagarias,et al.  Convergence Properties of the Nelder-Mead Simplex Method in Low Dimensions , 1998, SIAM J. Optim..

[43]  H. Yamabayashi,et al.  A 1‐year time course study of the relaxation times and histology for irradiated rat lungs , 1990, Magnetic resonance in medicine.

[44]  M. Rudin,et al.  Quantitative assessment of rat kidney function by measuring the clearance of the contrast agent Gd(DOTA) using dynamic MRI. , 2000, Magnetic resonance imaging.

[45]  The effects of simulated airway diseases and affected flow distributions on aerosol deposition. , 2010, Respiratory care.

[46]  H Salem,et al.  Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[47]  Andrew R. Martin,et al.  An in vitro assessment of aerosol delivery through patient breathing circuits used with medical air or a helium-oxygen mixture. , 2011, Journal of aerosol medicine and pulmonary drug delivery.

[48]  Gerhard Scheuch,et al.  Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. , 2008, American journal of respiratory and critical care medicine.

[49]  T. Sosnowski Importance of airway geometry and respiratory parameters variability for particle deposition in the human respiratory tract. , 2011, Journal of thoracic disease.

[50]  E. Haacke,et al.  Aerosol Delivery in Ventilated Newborn Pigs: An MRI Evaluation , 2008, Pediatric Research.

[51]  Per Wollmer,et al.  Site of deposition and absorption of an inhaled hydrophilic solute. , 2007, British journal of clinical pharmacology.

[52]  A. Macovski,et al.  Variable-rate selective excitation , 1988 .

[53]  D. Rubin,et al.  Maximum likelihood from incomplete data via the EM - algorithm plus discussions on the paper , 1977 .

[54]  C. Aaron,et al.  Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose‐only inhalation in rats , 1998, Journal of applied toxicology : JAT.

[55]  A. Louie,et al.  Positron emission tomography: A novel technique for investigating the biodistribution and transport of nanoparticles , 2010, Inhalation toxicology.

[56]  C. Faber,et al.  Early detection of lung inflammation: Exploiting T1‐effects of iron oxide particles using UTE MRI , 2012, Magnetic resonance in medicine.

[57]  S. Vedal,et al.  Carinal and tubular airway particle concentrations in the large airways of non-smokers in the general population: evidence for high particle concentration at airway carinas. , 1996, Occupational and environmental medicine.

[58]  Miriam Scadeng,et al.  Regional Distribution of Aerosol Deposition in Rat Lungs Using Magnetic Resonance Imaging , 2013, Annals of Biomedical Engineering.

[59]  D. Parker,et al.  Uncertainty and bias in contrast concentration measurements using spoiled gradient echo pulse sequences , 2008, Physics in medicine and biology.

[60]  K. Suga,et al.  Assessment of regional lung ventilation in dog lungs with Gd-DTPA aerosol ventilation MR imaging , 2002, Acta radiologica.

[61]  M. Lippmann,et al.  Particle deposition within bronchial airways: comparisons using constant and cyclic inspiratory flows. , 1982, The Annals of occupational hygiene.

[62]  A. Cutillo,et al.  Modeling the nuclear magnetic resonance behavior of lung: from electrical engineering to critical care medicine. , 1999, Bioelectromagnetics.