论文信息 - A novel method to fabricate bioabsorbable scaffolds

A novel method to fabricate bioabsorbable scaffolds

Abstract An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91–95%, median pore diameters ranging from 13 to 35 μm (with larger pore diameters greater than 200 μm), and specific pore area in the range 58–102 m 2 g −1 were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.

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