Tissue biomarkers for diagnosis & management of oral squamous cell carcinoma.

Squamous cell carcinoma (SCC) accounts for more than 90% of malignancies of the oral cavity and oropharynx. Globally, SCC is one of the top ten cancers with a predilection for older males. In the U.S., SCC accounts for more deaths annually than cervical cancer, malignant melanoma or Hodgkin's lymphoma and costs about 2 billion dollars in treatment expenses. The 5-year survival rate is less than 50%, a prognosis that is poorer than that of breast cancer or melanoma.2 Significant numbers of patients develop local recurrence, second primary tumors and distant metastases. Patients presenting with late stage disease resulting in poor survival, are common; in part due to inadequate screening protocols and access to care issues. In the following review article, the risk factors, current screening protocols, treatment options and biomarkers for diagnosis and prognosis of SCC, will be discussed.

[1]  J. Sudbø,et al.  The invasive front of carcinomas. The most important area for tumour prognosis? , 1998, Anticancer research.

[2]  Margaret Brandwein-Gensler,et al.  Oral Squamous Cell Carcinoma: Histologic Risk Assessment, but Not Margin Status, Is Strongly Predictive of Local Disease-free and Overall Survival , 2005, The American journal of surgical pathology.

[3]  Michaell A. Huber,et al.  Acetic acid wash and chemiluminescent illumination as an adjunct to conventional oral soft tissue examination for the detection of dysplasia: a pilot study. , 2004, Quintessence international.

[4]  H. Modjtahedi.  Molecular therapy of head and neck cancer , 2005, Cancer and Metastasis Reviews.

[5]  S. Chow,et al.  Diagnosis of oral cancer by light-induced autofluorescence spectroscopy using double excitation wavelengths. , 1999, Oral oncology.

[6]  L. Slater.  Oral brush biopsy: false positives redux. , 2004, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[7]  S. Wahl,et al.  Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma. , 2007, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[8]  P. Quax,et al.  Pericellular proteases in angiogenesis and vasculogenesis. , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[9]  C. Fisher,et al.  Tumour thickness predicts cervical nodal metastases and survival in early oral tongue cancer. , 2003, Oral oncology.

[10]  W. V. van Heerden,et al.  HPV detection in primary intra-oral squamous cell carcinomas--commensal, aetiological agent or contamination? , 2006, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[11]  I. Ganly,et al.  Recurrent squamous-cell carcinoma of the head and neck: overview of current therapy and future prospects. , 2000, Annals of oncology : official journal of the European Society for Medical Oncology.

[12]  H. Johansson,et al.  Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck , 1998, Cancer.

[13]  B. Schmidt,et al.  Overexpression of Matrix Metalloproteinase-1 and -9 mRNA Is Associated with Progression of Oral Dysplasia to Cancer , 2004, Clinical Cancer Research.

[14]  R. Lewensohn,et al.  Human papillomavirus (HPV) DNA in tonsillar cancer: Clinical correlates, risk of relapse, and survival , 2000, International journal of cancer.

[15]  G. Neufeld,et al.  Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants , 1996, Cancer and Metastasis Reviews.

[16]  E. Kerkelä,et al.  Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer , 2003, Experimental dermatology.

[17]  A. Leonard,et al.  Invasive front grading: reliability and usefulness in the management of oral squamous cell carcinoma. , 2003, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[18]  H. Tanzawa,et al.  Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control. , 2000, Oral oncology.

[19]  K I Bland,et al.  The prognostic and therapeutic value of frozen section determinations in the surgical treatment of squamous carcinoma of the head and neck. , 1978, American journal of surgery.

[20]  J. Foidart,et al.  Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase. , 1992, Cancer research.

[21]  A. Arnold,et al.  Cyclin D and oncogenesis. , 1993, Current opinion in genetics & development.

[22]  D. Thomas,et al.  Human papillomaviruses, herpes simplex viruses, and the risk of oral cancer in men. , 1992, American journal of epidemiology.

[23]  A. Jones.  Prognosis in mouth cancer: tumour factors. , 1994, European journal of cancer. Part B, Oral oncology.

[24]  S. Rogers,et al.  Survival, metastasis and recurrence of oral cancer in relation to pathological features. , 1995, Annals of the Royal College of Surgeons of England.

[25]  A. Mashberg.  Diagnosis of early oral and oropharyngeal squamous carcinoma: obstacles and their amelioration. , 2000, Oral oncology.

[26]  G. Elmberger,et al.  P16(INK4a) correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma. , 2005, Anticancer research.

[27]  T. Loree,et al.  Cancer of the buccal mucosa: are margins and T-stage accurate predictors of local control? , 2001, American journal of otolaryngology.

[28]  S. Wyatt,et al.  Trends and differentials in mortality from cancers of the oral cavity and pharynx in the United States, 1973–1987 , 1994, Cancer.

[29]  E. Dabelsteen,et al.  New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas. , 1989, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[30]  R. Todd,et al.  The molecular biology of oral carcinogenesis: toward a tumor progression model. , 1997, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[31]  A. Jemal,et al.  Cancer Statistics, 2006 , 2006, CA: a cancer journal for clinicians.

[32]  R. Jordan,et al.  Oral squamous cell carcinoma: new insights. , 1997, Journal.

[33]  L. Liotta,et al.  Tumor cell interactions with the extracellular matrix during invasion and metastasis. , 1993, Annual review of cell biology.

[34]  M. Gillison,et al.  Clinical implications of human papillomavirus in head and neck cancers. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[35]  J. Bosq,et al.  Lymph node prognostic factors in head and neck squamous cell carcinomas. , 1994, American journal of surgery.

[36]  D. Saranath,et al.  High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India. , 1991, British Journal of Cancer.

[37]  F. Cianfriglia,et al.  Multiple primary tumours in patients with oral squamous cell carcinoma. , 1999, Oral oncology.

[38]  J. Laissue,et al.  Human papillomavirus positive squamous cell carcinoma of the oropharynx , 2001, Cancer.

[39]  E. Strong,et al.  Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. , 1986, American journal of surgery.

[40]  J. Goldstein,et al.  Risk factors in head and neck cancer. , 1982, The New England journal of medicine.

[41]  L. Clark,et al.  The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck. , 1993, British Journal of Cancer.

[42]  M. Takahara,et al.  Expressions of Matrix Metalloproteinases in Early-Stage Oral Squamous Cell Carcinoma as Predictive Indicators for Tumor Metastases and Prognosis , 2004, Clinical Cancer Research.

[43]  W. Neville,et al.  Oral and Maxillofacial Pathology , 2004 .

[44]  C. O'brien,et al.  Tumor thickness influences prognosis of T1 and T2 oral cavity cancer—but what thickness? , 2003, Head & neck.

[45]  T. Carey,et al.  Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma , 2002, Head & neck.

[46]  S. Schwartz,et al.  Human Papillomavirus Infection and Survival in Oral Squamous Cell Cancer: A Population-Based Study , 2001, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[47]  W. Hong,et al.  Focus on head and neck cancer. , 2004, Cancer cell.

[48]  B. Hansson,et al.  Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: A population-based case-control study in southern Sweden , 2005, Acta oto-laryngologica.

[49]  S. Eccles,et al.  Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis , 2001, Cancer.

[50]  F. Marandino,et al.  Incidence of human papillomavirus infection in oral leukoplakia. Indications for a viral aetiology. , 2006, Journal of experimental & clinical cancer research : CR.

[51]  D. Lowy,et al.  High-risk human papillomavirus is sexually transmitted: evidence from a follow-up study of virgins starting sexual activity (intercourse). , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[52]  Michael C. Ostrowski,et al.  Cyclic AMP-dependent Activation of Rap1b (*) , 1995, The Journal of Biological Chemistry.

[53]  M. Leblanc,et al.  Does induction chemotherapy have a role in the management of locoregionally advanced squamous cell head and neck cancer? , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[54]  A. Mashberg,et al.  Toluidine blue--viewpoints. , 1999, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[55]  D. Summerlin,et al.  Oral malignancies associated with negative transepithelial brush biopsy. , 2003, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[56]  S. Preston‐Martin,et al.  Solar radiation, lip protection, and lip cancer risk in Los Angeles County women (California, United States) , 1996, Cancer Causes & Control.

[57]  Artur Ferreira,et al.  Oral squamous cell carcinoma: review of prognostic and predictive factors. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[58]  J. Olofsson,et al.  Prognostic factors in oral cavity carcinomas. , 1992, Acta oto-laryngologica. Supplementum.

[59]  D. Rimm,et al.  Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[60]  Li Mao,et al.  Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. , 2006, Neoplasia.

[61]  J. Grandis,et al.  Epidermal growth factor receptor biology in head and neck cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[62]  L. Turek,et al.  Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers , 2004, International journal of cancer.

[63]  G. Hannon,et al.  A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 , 1993, Nature.

[64]  Danielle W. Lu,et al.  Prevalence of Human Papillomavirus Type 16 DNA in Squamous Cell Carcinoma of the Palatine Tonsil, and Not the Oral Cavity, in Young Patients: A Distinct Clinicopathologic and Molecular Disease Entity , 2003, The American journal of surgical pathology.

[65]  G. Grillone,et al.  Inactivation of p53 and Amplification of Cyclin D1 Correlate With Clinical Outcome in Head and Neck Cancer , 1998, The Laryngoscope.

[66]  C. Miller,et al.  Human papillomavirus as a risk factor for oral squamous cell carcinoma: a meta-analysis, 1982-1997. , 2001, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[67]  J. Grandis,et al.  Head and neck cancer: recent advances and new standards of care. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[68]  C. O'brien,et al.  Neck dissection with and without radiotherapy: prognostic factors, patterns of recurrence, and survival. , 1986, American journal of surgery.

[69]  E. Strong,et al.  Significance of positive margins in oral cavity squamous carcinoma. , 1990, American journal of surgery.

[70]  O. Olopade,et al.  Cyclin D1 Amplification and p16(MTS1/CDK4I) Deletion Correlate With Poor Prognosis in Head and Neck Tumors , 2002, The Laryngoscope.

[71]  D. Brizel,et al.  Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: consensus, controversy, and conundrum. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[72]  Jacinto J. Regalado,et al.  Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma , 2005, International journal of experimental pathology.

[73]  S. Edström,et al.  Overexpression of p53‐Related Proteins Predicts Rapid Growth Rate of Head and Neck Cancer , 2001, The Laryngoscope.

[74]  Michaell A. Huber,et al.  Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. , 2005, The journal of contemporary dental practice.

[75]  Christopher U. Jones,et al.  Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. , 2006, The New England journal of medicine.

[76]  S. Franceschi,et al.  Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review , 2005, Cancer Epidemiology Biomarkers & Prevention.

[77]  H Stepp,et al.  Autofluorescence imaging and spectroscopy of normal and malignant mucosa in patients with head and neck cancer , 1999, Lasers in surgery and medicine.

[78]  A Mashberg,et al.  Early diagnosis of asymptomatic oral and oropharyngeal squamouscancers , 1995, CA: a cancer journal for clinicians.

[79]  Tim K. Lee,et al.  Adverse effects of ultraviolet radiation: a brief review. , 2006, Progress in biophysics and molecular biology.

[80]  Z. Suba,et al.  The prognostic role of clinical, morphological and molecular markers in oral squamous cell tumors. , 2005, Neoplasma.

[81]  M. Poljak,et al.  Human papillomaviruses (HPV) in tissue specimens of oral squamous cell papillomas and normal oral mucosa. , 2006, Anticancer research.

[82]  B. Perez-Ordonez,et al.  Molecular biology of squamous cell carcinoma of the head and neck , 2006, Journal of Clinical Pathology.

[83]  J. Piffkó,et al.  Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy? , 2004, Oral oncology.

[84]  S C Shiboski,et al.  Trends in oral cancer rates in the United States, 1973-1996. , 2000, Community dentistry and oral epidemiology.

[85]  S. Shintani,et al.  Inactivation of the p14ARF, p15INK4B and p16INK4A genes is a frequent event in human oral squamous cell carcinomas , 2001 .

[86]  J. Epstein,et al.  The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma. , 1997, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[87]  Y. Takano,et al.  Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor. , 2003, Oral oncology.

[88]  B. Ames,et al.  Too many rodent carcinogens: mitogenesis increases mutagenesis. , 1990, Science.