Phylogenetic perspectives in innate immunity.

The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

[1]  S. Kawabata,et al.  New types of clotting factors and defense molecules found in horseshoe crab hemolymph: their structures and functions. , 1998, Journal of biochemistry.

[2]  R. Steward.  Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel. , 1987, Science.

[3]  G. Hardiman,et al.  A family of human receptors structurally related to Drosophila Toll. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[4]  G. Rune,et al.  Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection , 1997, Nature.

[5]  K. Anderson,et al.  A conserved signaling pathway: the Drosophila toll-dorsal pathway. , 1996, Annual review of cell and developmental biology.

[6]  T. Feizi,et al.  AIDS and glycosylation. , 1990, Glycobiology.

[7]  F. Rosen,et al.  Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3). , 1970, The New England journal of medicine.

[8]  R. Ezekowitz,et al.  Collectins: pattern recognition molecules involved in first line host defense. , 1993, Current opinion in immunology.

[9]  D. Morrison,et al.  Endotoxins and disease mechanisms. , 1987, Annual review of medicine.

[10]  Christina H. Park,et al.  Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. , 1998, The Journal of clinical investigation.

[11]  J. Weiss.  Leukocyte-derived antimicrobial proteins. , 1994, Current opinion in hematology.

[12]  R. Ulevitch,et al.  CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. , 1990, Science.

[13]  J. Beier,et al.  Malaria parasite development in mosquitoes. , 1998, Annual review of entomology.

[14]  R. Ulevitch,et al.  Recognition of gram-negative bacteria and endotoxin by the innate immune system. , 1999, Current opinion in immunology.

[15]  R. Sakai,et al.  Genetic selection of a Plasmodium-refractory strain of the malaria vector Anopheles gambiae. , 1986, Science.

[16]  W. Weis,et al.  Structural basis of lectin-carbohydrate recognition. , 1996, Annual review of biochemistry.

[17]  M. Selsted,et al.  Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms , 1994, Infection and immunity.

[18]  R. Medzhitov,et al.  The Toll-receptor family and control of innate immunity. , 1999, Current opinion in immunology.

[19]  Wayne A. Hendrickson,et al.  Structure of a C-type mannose-binding protein complexed with an oligosaccharide , 1992, Nature.

[20]  P. Ricciardi-Castagnoli,et al.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.

[21]  P. Elsbach,et al.  Role of the bactericidal/permeability-increasing protein in host defence. , 1998, Current opinion in immunology.

[22]  Jonathan D. G. Jones,et al.  PLANT DISEASE RESISTANCE GENES. , 1997, Annual review of plant physiology and plant molecular biology.

[23]  M. Levine,et al.  Dif, a dorsal-related gene that mediates an immune response in Drosophila , 1993, Cell.

[24]  Defensins. Natural peptide antibiotics of human neutrophils. , 1985 .

[25]  T. Fujita,et al.  Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease , 1992, The Journal of experimental medicine.

[26]  E. Greenberg,et al.  Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid , 1996, Cell.

[27]  M. Nonaka,et al.  Complete complementary DNA sequence of the third component of complement of lamprey. Implication for the evolution of thioester containing proteins. , 1992, Journal of immunology.

[28]  J. Botas,et al.  The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. , 1994, Development.

[29]  K. Vernick,et al.  Plasmodium gallinaceum: a refractory mechanism of ookinete killing in the mosquito, Anopheles gambiae. , 1995, Experimental parasitology.

[30]  T. Ganz,et al.  Isolation of human intestinal defensins from ileal neobladder urine , 1998, FEBS letters.

[31]  S. Sheriff,et al.  The collectins in innate immunity. , 1996, Current opinion in immunology.

[32]  S. Thiel,et al.  ASSOCIATION OF LOW LEVELS OF MANNAN-BINDING PROTEIN WITH A COMMON DEFECT OF OPSONISATION , 1989, The Lancet.

[33]  C. Janeway,et al.  Innate Immunity: The Virtues of a Nonclonal System of Recognition , 1997, Cell.

[34]  M. Ackermann,et al.  Epithelial antibiotic induced in states of disease. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Franky R. G. Terras,et al.  Plant Defensins: Novel Antimicrobial Peptides as Components of the Host Defense System , 1995, Plant physiology.

[36]  R. Locksley,et al.  The Instructive Role of Innate Immunity in the Acquired Immune Response , 1996, Science.

[37]  J. Silver,et al.  Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. , 1996, Immunity.

[38]  L. Larivière,et al.  Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4) , 1999, The Journal of experimental medicine.

[39]  A. Aderem,et al.  Mechanisms of phagocytosis in macrophages. , 1999, Annual review of immunology.

[40]  M. Selsted,et al.  Defensins in granules of phagocytic and non-phagocytic cells. , 1995, Trends in cell biology.

[41]  H. G. Boman,et al.  Peptide antibiotics and their role in innate immunity. , 1995, Annual review of immunology.

[42]  J. Wright,et al.  Immunomodulatory Functions of Surfactant , 1995, Physiological reviews.

[43]  J. Kinoshita.  Women Fight Uphill Battle for Equity , 1996, Science.

[44]  David G. Schatz,et al.  Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system , 1998, Nature.

[45]  S. Dinesh-Kumar,et al.  Signaling in plant-microbe interactions. , 1997, Science.

[46]  M. Lehane,et al.  Midgut-specific immune molecules are produced by the blood-sucking insect Stomoxys calcitrans. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[47]  D Eisenberg,et al.  Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. , 1997, Science.

[48]  C. Epstein,et al.  Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[49]  D. Coggon,et al.  Prospective cohort study of predictors of incident low back pain in nurses , 1997, BMJ.

[50]  K. Matsuzaki,et al.  Magainins as paradigm for the mode of action of pore forming polypeptides. , 1998, Biochimica et biophysica acta.

[51]  K. Reid,et al.  The proteolytic activation systems of complement. , 1981, Annual review of biochemistry.

[52]  Antony Rodriguez,et al.  The 18‐wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense , 1997, The EMBO journal.

[53]  M. Turner,et al.  Mannose-binding lectin: the pluripotent molecule of the innate immune system. , 1996, Immunology today.

[54]  R. Gallo,et al.  Antimicrobial peptides: an emerging concept in cutaneous biology. , 1998, The Journal of investigative dermatology.

[55]  L. Cerenius,et al.  Role of the prophenoloxidase-activating system in invertebrate immunity. , 1998, Current opinion in immunology.

[56]  D. Jackson,et al.  Bovine and mouse serum beta inhibitors of influenza A viruses are mannose-binding lectins. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[57]  K. Anderson,et al.  Regulated nuclear import of Rel proteins in the Drosophila immune response , 1998, Nature.

[58]  D. Klessig,et al.  Signal perception and transduction in plant defense responses. , 1997, Genes & development.

[59]  M. Meister,et al.  A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[60]  S. Thiel,et al.  A second serine protease associated with mannan-binding lectin that activates complement , 1997, Nature.

[61]  M. Kawakami,et al.  A 100-kDa protein in the C4-activating component of Ra-reactive factor is a new serine protease having module organization similar to C1r and C1s. , 1994, Journal of immunology.

[62]  J. Costerton,et al.  Bacterial biofilms: a common cause of persistent infections. , 1999, Science.

[63]  M. Meister,et al.  Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[64]  C. Janeway.  Approaching the asymptote? Evolution and revolution in immunology. , 1989, Cold Spring Harbor symposia on quantitative biology.

[65]  E. Crouch.  Collectins and pulmonary host defense. , 1998, American journal of respiratory cell and molecular biology.

[66]  T. Fujita,et al.  Complement-related serine proteases in tunicates and vertebrates. , 1998, Current opinion in immunology.

[67]  B. Trask,et al.  Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. , 1998, Blood.

[68]  Warren Hs.  Strategies for the treatment of sepsis. , 1997 .

[69]  M. Walport,et al.  Molecular basis of polymorphisms of human complement component C3 , 1990, The Journal of experimental medicine.

[70]  D. Hultmark,et al.  Immune reactions in Drosophila and other insects: a model for innate immunity. , 1993, Trends in genetics : TIG.

[71]  F. Kafatos,et al.  Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes , 1997, The EMBO journal.

[72]  R. Ezekowitz.  Ante-antibody immunity , 1991, Current Biology.

[73]  Y. Shai,et al.  Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. , 1996, Journal of molecular biology.

[74]  R I Lehrer,et al.  Antimicrobial peptides of vertebrates. , 1998, Current opinion in immunology.

[75]  W. Weis,et al.  The C‐type lectin superfamily in the immune system , 1998, Immunological reviews.

[76]  J. Whitsett,et al.  Surfactant protein A-deficient mice are susceptible to group B streptococcal infection. , 1997, Journal of immunology.

[77]  A. Dutra,et al.  Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. , 1996, Genomics.

[78]  P. Eggleton,et al.  Lung surfactant proteins involved in innate immunity. , 1999, Current opinion in immunology.

[79]  H. Bluethmann,et al.  Molecules and mechanisms operating in septic shock: lessons from knockout mice. , 1997, Immunology today.

[80]  P. Elsbach,et al.  An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domains. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[81]  R. Steward,et al.  Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting. , 1991, Trends in genetics : TIG.

[82]  P. Lachmann,et al.  Inherited deficiencies of the terminal components of human complement. , 1992, Immunodeficiency reviews.

[83]  Wayne L. Smith,et al.  Purification, primary structures, and antibacterial activities of β-defensins, a new family of antimicrobial peptides from bovine neutrophils. , 1996, The Journal of Biological Chemistry.

[84]  R. Gennaro,et al.  The Cathelicidin Family of Antimicrobial Peptide Precursors: A Component of the Oxygen‐Independent Defense Mechanisms of Neutrophils a , 1997, Annals of the New York Academy of Sciences.

[85]  D. Hultmark,et al.  Sequence and specificity of two antibacterial proteins involved in insect immunity , 1981, Nature.

[86]  R. Ulevitch,et al.  Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum , 1986, The Journal of experimental medicine.

[87]  B. Lemaître,et al.  A drosomycin–GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway , 1998, The EMBO journal.

[88]  C. Janeway,et al.  MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. , 1998, Molecular cell.

[89]  D. Hultmark,et al.  Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[90]  D. Golenbock,et al.  LPS‐binding proteins and receptors , 1998, Journal of leukocyte biology.

[91]  B. Lemaître,et al.  The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults , 1996, Cell.