Basis for sudden cardiac death prediction by T-wave alternans from an integrative physiology perspective.

[1]  J. Gottdiener,et al.  Effects of Acute Mental Stress and Exercise on T-Wave Alternans in Patients With Implantable Cardioverter Defibrillators and Controls , 2004, Circulation.

[2]  Robert F Gilmour,et al.  Ionic mechanism of electrical alternans. , 2002, American journal of physiology. Heart and circulatory physiology.

[3]  E. Kaufman,et al.  Influence of heart rate and sympathetic stimulation on arrhythmogenic T wave alternans. , 2000, American journal of physiology. Heart and circulatory physiology.

[4]  M. Diaz,et al.  Sarcoplasmic Reticulum Calcium Content Fluctuation Is the Key to Cardiac Alternans , 2004, Circulation research.

[5]  H. Morita,et al.  Clinical Significance of Macroscopic T‐Wave Alternans After Sodium Channel Blocker Administration in Patients with Brugada Syndrome , 2007, Journal of cardiovascular electrophysiology.

[6]  Jari Viik,et al.  Enhanced Predictive Power of Quantitative TWA during Routine Exercise Testing in the Finnish Cardiovascular Study , 2009, Journal of cardiovascular electrophysiology.

[7]  R. Verrier,et al.  Progressive Increases in Complexity of T-Wave Oscillations Herald Ischemia-Induced Ventricular Fibrillation , 2002, Circulation research.

[8]  P. Stein,et al.  Ambulatory ECG‐Based T‐Wave Alternans Predicts Sudden Cardiac Death in High‐Risk Post‐MI Patients with Left Ventricular Dysfunction in the EPHESUS Study , 2008, Journal of cardiovascular electrophysiology.

[9]  Robert F Gilmour,et al.  Contribution of IKr to Rate-Dependent Action Potential Dynamics in Canine Endocardium , 2004, Circulation research.

[10]  Jari Viik,et al.  Post-exercise assessment of cardiac repolarization alternans in patients with coronary artery disease using the modified moving average method. , 2009, Journal of the American College of Cardiology.

[11]  M. Mittleman,et al.  Abstract 4118: Crescendo T-Wave Alternans Prior to VT in Hospitalized Decompensated Heart Failure Patients in the PRECEDENT Trial , 2008 .

[12]  Barry J Maron,et al.  American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. A scientific statement from the American Heart Association Council on Clinical Cardi , 2008, Journal of the American College of Cardiology.

[13]  John E Madias,et al.  Ambulatory ECG-based T-wave alternans. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[14]  Robert S Sheldon,et al.  Noninvasive risk assessment early after a myocardial infarction the REFINE study. , 2007, Journal of the American College of Cardiology.

[15]  Daniel P. Morin,et al.  Effect of oral β-blocker therapy on microvolt T-wave alternans and electrophysiology testing in patients with ischemic cardiomyopathy , 2007 .

[16]  Shien-Fong Lin,et al.  Spatial Heterogeneity of Calcium Transient Alternans During the Early Phase of Myocardial Ischemia in the Blood-Perfused Rabbit Heart , 2001, Circulation.

[17]  D. Zipes,et al.  Thoracic Spinal Cord Stimulation Reduces the Risk of Ischemic Ventricular Arrhythmias in a Postinfarction Heart Failure Canine Model , 2005, Circulation.

[18]  Takanori Ikeda,et al.  Predictive value of microvolt T-wave alternans for sudden cardiac death in patients with preserved cardiac function after acute myocardial infarction: results of a collaborative cohort study. , 2006, Journal of the American College of Cardiology.

[19]  S. Hohnloser,et al.  Effect of metoprolol and d,l-sotalol on microvolt-level T-wave alternans. Results of a prospective, double-blind, randomized study. , 2001, Journal of the American College of Cardiology.

[20]  W. Clusin,et al.  Mechanisms of calcium transient and action potential alternans in cardiac cells and tissues. , 2008, American journal of physiology. Heart and circulatory physiology.

[21]  R. Verrier,et al.  Tracking cardiac electrical instability by computing interlead heterogeneity of T-wave morphology. , 2003, Journal of applied physiology.

[22]  A. Garfinkel,et al.  From Pulsus to Pulseless: The Saga of Cardiac Alternans , 2006, Circulation research.

[23]  V. Shusterman,et al.  Upsurge in T-Wave Alternans and Nonalternating Repolarization Instability Precedes Spontaneous Initiation of Ventricular Tachyarrhythmias in Humans , 2006, Circulation.

[24]  Takanori Ikeda,et al.  Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective study. , 2009, Heart rhythm.

[25]  G. D. De Ferrari,et al.  T-wave alternans in risk stratification of patients with nonischemic dilated cardiomyopathy: can it help to better select candidates for ICD implantation? , 2009, Heart rhythm.

[26]  R. Verrier,et al.  Quantification of ischaemia induced vulnerability by precordial T wave alternans analysis in dog and human. , 1994, Cardiovascular research.

[27]  Y. Kagaya,et al.  Microvolt T Wave Alternans in Human Cardiac Hypertrophy: Electrical Instability and Abnormal Myocardial Arrangement , 2001, Journal of cardiovascular electrophysiology.

[28]  M. Josephson,et al.  Chapter 98 – Cardiac Arrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy , 2005 .

[29]  R. Verrier,et al.  Angerlike behavioral state potentiates myocardial ischemia-induced T-wave alternans in canines. , 2001, Journal of the American College of Cardiology.

[30]  Alan Garfinkel,et al.  Spatially Discordant Alternans in Cardiac Tissue: Role of Calcium Cycling , 2006 .

[31]  D. Rosenbaum,et al.  Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. , 1999, Circulation.

[32]  S. Narayan.  T-wave alternans and the susceptibility to ventricular arrhythmias. , 2006, Journal of the American College of Cardiology.

[33]  R. Sandhu,et al.  Intracardiac alternans compared to surface T-wave alternans as a predictor of ventricular arrhythmias in humans. , 2008, Heart rhythm.

[34]  Richard J Cohen,et al.  "Indeterminate" microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction. , 2006, Journal of the American College of Cardiology.

[35]  Luigi Tavazzi,et al.  Long term vagal stimulation in patients with advanced heart failure First experience in man , 2008, European journal of heart failure.

[36]  J. Ruskin,et al.  Electrical alternans and vulnerability to ventricular arrhythmias. , 1994, The New England journal of medicine.

[37]  Daniel P. Morin,et al.  Effect of oral beta-blocker therapy on microvolt T-wave alternans and electrophysiology testing in patients with ischemic cardiomyopathy. , 2007, American heart journal.

[38]  José Jalife,et al.  Action potential duration restitution portraits of mammalian ventricular myocytes: role of calcium current. , 2006, Biophysical journal.

[39]  R. Grimaldi,et al.  Spinal cord stimulation affects T-wave alternans in patients with ischaemic cardiomyopathy: a pilot study. , 2008, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[40]  R. Peters,et al.  Effects of Selective Autonomic Blockade on T-Wave Alternans in Humans , 2002, Circulation.

[41]  G. Breithardt,et al.  Life-threatening Arrhythmias Genotype-phenotype Correlation in the Long-qt Syndrome : Gene-specific Triggers for Genotype-phenotype Correlation in the Long-qt Syndrome Gene-specific Triggers for Life-threatening Arrhythmias , 2022 .

[42]  D. Mark,et al.  Role of Microvolt T-Wave Alternans in Assessment of Arrhythmia Vulnerability Among Patients With Heart Failure and Systolic Dysfunction: Primary Results From the T-Wave Alternans Sudden Cardiac Death in Heart Failure Trial Substudy , 2008, Circulation.

[43]  A. Garfinkel,et al.  Preventing ventricular fibrillation by flattening cardiac restitution. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[44]  V. Shusterman,et al.  Anger-induced T-wave alternans predicts future ventricular arrhythmias in patients with implantable cardioverter-defibrillators. , 2009, Journal of the American College of Cardiology.

[45]  R. Verrier,et al.  Electrophysiologic Basis for T Wave Alternans as an Index of Vulnerability to Ventricular Fibrillation , 1994, Journal of cardiovascular electrophysiology.

[46]  R. Verrier,et al.  Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracy. , 2002, Journal of applied physiology.

[47]  Takanori Ikeda,et al.  Evidence regarding clinical use of microvolt T-wave alternans. , 2008, Heart rhythm.

[48]  J. Bigger,et al.  Ambulatory Electrocardiogram‐Based Tracking of T Wave Alternans in Postmyocardial Infarction Patients to Assess Risk of Cardiac Arrest or Arrhythmic Death , 2003, Journal of cardiovascular electrophysiology.

[49]  O. Voroshilovsky,et al.  High amplitude T-wave alternans precedes spontaneous ventricular tachycardia or fibrillation in ICD electrograms. , 2008, Heart rhythm.

[50]  M. Cheitlin,et al.  Does Microvolt T-Wave Alternans Testing Predict Ventricular Tachyarrhythmias in Patients With Ischemic Cardiomyopathy and Prophylactic Defibrillators? The MASTER (Microvolt T Wave Alternans Testing for Risk Stratification of Post-Myocardial Infarction Patients) Trial , 2009 .

[51]  C. Antzelevitch,et al.  Cellular and ionic basis for T-wave alternans under long-QT conditions. , 1999, Circulation.

[52]  J. A. Gomes,et al.  Microvolt T-wave alternans for the risk stratification of ventricular tachyarrhythmic events: a meta-analysis. , 2005, Journal of the American College of Cardiology.

[53]  R. Verrier,et al.  Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave. , 1991, Science.

[54]  R. Verrier,et al.  Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazem. , 1996, Journal of cardiovascular pharmacology.

[55]  Heikki Huikuri,et al.  T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. , 2007, European heart journal.

[56]  M. Cutler,et al.  Explaining the clinical manifestations of T wave alternans in patients at risk for sudden cardiac death. , 2009, Heart rhythm.

[57]  M. Kryger,et al.  Principles and Practice of Sleep Medicine , 1989 .

[58]  S. Hohnloser,et al.  Quantitative Assessment of Microvolt T‐Wave Alternans in Patients with Congestive Heart Failure , 2005, Journal of cardiovascular electrophysiology.

[59]  P. Picton,et al.  Endocardial and epicardial repolarization alternans in human cardiomyopathy: evidence for spatiotemporal heterogeneity and correlation with body surface T-wave alternans. , 2007, Journal of the American College of Cardiology.

[60]  T. Young,et al.  Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Coun , 2008, Circulation.

[61]  A. Camm,et al.  Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction , 1999, The Lancet.