Structural and functional healing of critical‐size segmental bone defects by transduced muscle‐derived cells expressing BMP4

Our previous studies have shown that muscle‐derived cells, including a population of muscle stem cells, transduced with a retroviral vector expressing bone morphogenetic protein 4 (BMP4) can improve the healing of critical‐size calvarial defects. However, we did not evaluate the functionality of the healed bone. The purpose of this study was to determine whether primary muscle‐derived cells transduced with retroBMP4 can heal a long bone defect both structurally and functionally.

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