The relationship between protoporphyrin IX photobleaching during real‐time dermatological methyl‐aminolevulinate photodynamic therapy (MAL‐PDT) and subsequent clinical outcome

The relationship between protoporphyrin IX (PpIX) photobleaching and cellular damage during aminolevulinic (ALA) photodynamic therapy (PDT) has been studied at the cellular level. This study assessed the capability of a non‐invasive fluorescence imaging system (Dyaderm, Biocam, Germany), to monitor changes in PpIX during real time methyl‐aminolevulinate (MAL) PDT in dermatological lesions, and thus to act as a predictive tool in terms of observed clinical outcome post‐treatment.

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