De novo nucleotide biosynthetic pathway and cancer

[1]  Li Tan,et al.  Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy , 2022, Frontiers in Oncology.

[2]  Tao Wang,et al.  Pyrimidine Biosynthetic Enzyme CAD: Its Function, Regulation, and Diagnostic Potential , 2021, International journal of molecular sciences.

[3]  W. Roth,et al.  Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma , 2021, Zeitschrift für Gastroenterologie.

[4]  Shenmin Zhang,et al.  Long non-coding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple negative breast cancer , 2020 .

[5]  F. Di Virgilio,et al.  Extracellular ATP: A Feasible Target for Cancer Therapy , 2020, Cells.

[6]  W. Dai,et al.  Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma , 2020, Journal of Experimental & Clinical Cancer Research.

[7]  S. Benkovic,et al.  Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells , 2020, Science.

[8]  P. Ceppi,et al.  A non-proliferative role of pyrimidine metabolism in cancer , 2020, Molecular metabolism.

[9]  S. Varambally,et al.  Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities. , 2019, Cancer letters.

[10]  Eric P. Smith,et al.  Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story , 2019, Cancers.

[11]  Andrew R. Morton,et al.  Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells , 2019, Science Translational Medicine.

[12]  C. Thompson,et al.  Metabolic regulation of cell growth and proliferation , 2019, Nature Reviews Molecular Cell Biology.

[13]  W. Qiu,et al.  Cell cycle-dependent phosphorylation of PRPS1 fuels nucleotide synthesis and promotes tumorigenesis. , 2019, Cancer research.

[14]  D. A. Foster,et al.  Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells , 2019, Trends in Endocrinology & Metabolism.

[15]  I. Ben-Sahra,et al.  Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides , 2019, Cancers.

[16]  J. Sanders,et al.  SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long‐lived Myc hypomorphic mice , 2019, Aging cell.

[17]  Juan Li,et al.  Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer , 2019, Molecular Cancer.

[18]  N. Neamati,et al.  Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer , 2019, Pharmacology & therapeutics.

[19]  Yaoqi Zhou,et al.  Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. , 2019, Cell metabolism.

[20]  Yulong Yin,et al.  Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy , 2018, Front. Immunol..

[21]  A. Tomassetti,et al.  One-Carbon Metabolism: Biological Players in Epithelial Ovarian Cancer , 2018, International journal of molecular sciences.

[22]  K. Brown,et al.  Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer. , 2017, Cancer discovery.

[23]  D. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[24]  P. Stover,et al.  Targeting nuclear thymidylate biosynthesis. , 2017, Molecular aspects of medicine.

[25]  J. Menéndez,et al.  Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users , 2017, Nutrients.

[26]  T. Meitinger,et al.  CAD mutations and uridine-responsive epileptic encephalopathy , 2017, Brain : a journal of neurology.

[27]  Zhimin Lu,et al.  Fructokinase A acts as a protein kinase to promote nucleotide synthesis , 2016, Cell cycle.

[28]  D. Hawke,et al.  A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation , 2016, Nature Cell Biology.

[29]  V. Polzonetti,et al.  Enzymology of Pyrimidine Metabolism and Neurodegeneration. , 2016, Current medicinal chemistry.

[30]  S. Manalis,et al.  Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. , 2016, Developmental cell.

[31]  J. Asara,et al.  mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle , 2016, Science.

[32]  W. Guo,et al.  MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. , 2015, Gastroenterology.

[33]  C. Dang,et al.  MYC and metabolism on the path to cancer. , 2015, Seminars in cell & developmental biology.

[34]  S. Varambally,et al.  Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer , 2015, Oncotarget.

[35]  A. Ferrando,et al.  Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL , 2015, Nature Medicine.

[36]  R. Deberardinis,et al.  Metabolic pathways promoting cancer cell survival and growth , 2015, Nature Cell Biology.

[37]  A. Lane,et al.  Regulation of mammalian nucleotide metabolism and biosynthesis , 2015, Nucleic acids research.

[38]  Jingjing Jiang,et al.  Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis. , 2014, Molecular cell.

[39]  Gideon Blumenthal,et al.  Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis , 2014, The Lancet.

[40]  P. Jiang,et al.  Regulation of the pentose phosphate pathway in cancer , 2014, Protein & Cell.

[41]  D. Ruggero,et al.  Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer , 2014, Cell.

[42]  V. Mootha,et al.  Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer , 2014, Nature Communications.

[43]  Benjamin G. Bitler,et al.  Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. , 2013, Cell reports.

[44]  J. Asara,et al.  Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 , 2013, Science.

[45]  J. Manfredi,et al.  E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression. , 2012, Genes & development.

[46]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[47]  Jennifer E. Van Eyk,et al.  c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2016 .

[48]  D. Zhuang,et al.  Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells , 2008, Cell cycle.

[49]  Frederic D Sigoillot,et al.  Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase. , 2007, Frontiers in bioscience : a journal and virtual library.

[50]  J. Rathmell,et al.  Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. , 2007, Molecular biology of the cell.

[51]  N. Hay,et al.  Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt , 2006, Oncogene.

[52]  M. Hall,et al.  TOR Signaling in Growth and Metabolism , 2006, Cell.

[53]  H. Simmonds,et al.  Pyrimidine pathways in health and disease. , 2005, Trends in molecular medicine.

[54]  Frederic D Sigoillot,et al.  Nuclear Localization and Mitogen-activated Protein Kinase Phosphorylation of the Multifunctional Protein CAD* , 2005, Journal of Biological Chemistry.

[55]  Jun Cao,et al.  Influence of methionine/valine-depleted enteral nutrition on nucleic acid and protein metabolism in tumor-bearing rats. , 2003, World journal of gastroenterology.

[56]  Frederic D Sigoillot,et al.  Cell Cycle-dependent Regulation of Pyrimidine Biosynthesis* , 2003, The Journal of Biological Chemistry.

[57]  M. Relling,et al.  De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo. , 2002, Blood.

[58]  P. Farnham,et al.  Myc versus USF: discrimination at the cad gene is determined by core promoter elements , 1997, Molecular and cellular biology.

[59]  D. Evans,et al.  Mammalian carbamyl phosphate synthetase (CPS). DNA sequence and evolution of the CPS domain of the Syrian hamster multifunctional protein CAD. , 1990, The Journal of biological chemistry.

[60]  T. Aoki,et al.  Carbamoyl phosphate synthetase (glutamine-hydrolyzing): increased activity in cancer cells. , 1981, Science.

[61]  Zhimin Lu,et al.  Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress. , 2018, Cancer discovery.

[62]  B. Faubert,et al.  Myc induces expression of glutamine synthetase through promoter demethylation , 2015 .

[63]  Jianping Ding,et al.  Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site. , 2007, The Biochemical journal.

[64]  R. Watts,et al.  Purine de novo synthesis and salvage during testicular development in the rat. , 1986 .