Molecular mechanisms of cholesterol absorption and transport in the intestine.

[1]  E. Ikonen,et al.  Cellular pathology of Niemann-Pick type C disease. , 2004, Seminars in cell & developmental biology.

[2]  R. Dwek,et al.  Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C , 2004, Neurobiology of Disease.

[3]  Guorong Xu,et al.  Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase. , 2004, Metabolism: clinical and experimental.

[4]  P. Ziajka,et al.  Initial low-density lipoprotein response to statin therapy predicts subsequent low-density lipoprotein response to the addition of ezetimibe. , 2004, The American journal of cardiology.

[5]  Luquan Wang,et al.  Materials and Methods Figs. S1 to S4 Tables S1 and S2 References Niemann-pick C1 like 1 Protein Is Critical for Intestinal Cholesterol Absorption , 2022 .

[6]  P. Howles,et al.  Pancreatic Triglyceride Lipase Deficiency Minimally Affects Dietary Fat Absorption but Dramatically Decreases Dietary Cholesterol Absorption in Mice* , 2003, Journal of Biological Chemistry.

[7]  P. Dawson,et al.  Targeted Deletion of the Ileal Bile Acid Transporter Eliminates Enterohepatic Cycling of Bile Acids in Mice* , 2003, Journal of Biological Chemistry.

[8]  Hetal N. Patel,et al.  Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders , 2003, Nature Genetics.

[9]  M. Hayden,et al.  ABCA1 Is Essential for Efficient Basolateral Cholesterol Efflux during the Absorption of Dietary Cholesterol in Chickens* , 2003, The Journal of Biological Chemistry.

[10]  R. Suresh,et al.  Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. , 2003, European heart journal.

[11]  C. Farley,et al.  Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats , 2003, British journal of pharmacology.

[12]  Ann-Margret Östlund-Lindqvist,et al.  Pharmacological interference with intestinal bile acid transport reduces plasma cholesterol in LDL receptor/apoE deficiency , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  F. Gorelick,et al.  COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport vesicle , 2003, Journal of Cell Science.

[14]  M. Lowe,et al.  The triglyceride lipases of the pancreas Published, JLR Papers in Press, October 1, 2002. DOI 10.1194/jlr.R200012-JLR200 , 2002, Journal of Lipid Research.

[15]  Jonathan C. Cohen,et al.  Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Meehyung Cho,et al.  Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia. , 2002, The American journal of cardiology.

[17]  D. Tribble,et al.  Inhibition of Intestinal Cholesterol Absorption by Ezetimibe in Humans , 2002, Circulation.

[18]  H. Gylling,et al.  Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption DOI 10.1194/jlr.M200155-JLR200 , 2002, Journal of Lipid Research.

[19]  Jonathan C. Cohen,et al.  Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface , 2002 .

[20]  Jonathan C. Cohen,et al.  Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. , 2002, The Journal of clinical investigation.

[21]  Chari D Smith,et al.  Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94 DOI 10.1194/jlr.M200121-JLR200 , 2002, Journal of Lipid Research.

[22]  H. Hobbs,et al.  Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β* , 2002, The Journal of Biological Chemistry.

[23]  P. Tso,et al.  Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. , 2002, Journal of lipid research.

[24]  P. Howles,et al.  Bile Salt-stimulated Carboxyl Ester Lipase Influences Lipoprotein Assembly and Secretion in Intestine , 2002, The Journal of Biological Chemistry.

[25]  C. Strader,et al.  The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption. , 2002, Biochimica et biophysica acta.

[26]  R. Schekman,et al.  Surface structure of the COPII-coated vesicle , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[27]  D. Lombardo,et al.  Transcytosis of pancreatic bile salt-dependent lipase through human Int407 intestinal cells. , 2001, Experimental cell research.

[28]  A. Bielawska,et al.  Determination of ceramides and diglycerides by the diglyceride kinase assay. , 2001, Analytical biochemistry.

[29]  C. Farley,et al.  Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function , 2001, British journal of pharmacology.

[30]  D. Wexler,et al.  The Plasma Concentration and LDL‐C Relationship in Patients Receiving Ezetimibe , 2001, Journal of clinical pharmacology.

[31]  S. Walkley,et al.  Critical role for glycosphingolipids in Niemann-Pick disease type C , 2001, Current Biology.

[32]  A. Pandya,et al.  Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. , 2001, American journal of human genetics.

[33]  H. Brewer,et al.  ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. , 2001, The Journal of clinical investigation.

[34]  P. Howles,et al.  Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine. , 2001, Journal of lipid research.

[35]  G. Taylor,et al.  Determinants of Variable Response to Statin Treatment in Patients With Refractory Familial Hypercholesterolemia , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[36]  W. Fung-Leung,et al.  ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism. , 2001, Gastroenterology.

[37]  A. Rigotti,et al.  Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. , 2001, Journal of lipid research.

[38]  H. Heuer,et al.  Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporter , 2000, FEBS letters.

[39]  D. Ory Niemann-Pick type C: a disorder of cellular cholesterol trafficking. , 2000, Biochimica et biophysica acta.

[40]  N. Grishin,et al.  Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. , 2000, Science.

[41]  M. Tagaya,et al.  Implication of sphingolipid metabolism in the stability of the Golgi apparatus. , 2000, Journal of cell science.

[42]  D. Mangelsdorf,et al.  Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. , 2000, Science.

[43]  Y. Chao,et al.  A target for cholesterol absorption inhibitors in the enterocyte brush border membrane. , 2000, Biochimica et biophysica acta.

[44]  Y. Chao,et al.  Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter. , 2000, Biochimica et biophysica acta.

[45]  A. Nilsson,et al.  A mutual inhibitory effect on absorption of sphingomyelin and cholesterol. , 2000, The Journal of nutritional biochemistry.

[46]  B. Levy,et al.  Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1. , 2000, Genomics.

[47]  C. Gabel,et al.  High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Y. Ioannou,et al.  Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network. , 1999, Molecular genetics and metabolism.

[49]  D. Hui,et al.  Pancreatic lipase/colipase-mediated triacylglycerol hydrolysis is required for cholesterol transport from lipid emulsions to intestinal cells. , 1999, The Biochemical journal.

[50]  M. Patterson,et al.  The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo* , 1999, The Journal of Biological Chemistry.

[51]  N Suresh Kumar,et al.  Prechylomicron transport vesicle: isolation and partial characterization. , 1999, American journal of physiology. Gastrointestinal and liver physiology.

[52]  F. E. Weber,et al.  Identification of a receptor mediating absorption of dietary cholesterol in the intestine. , 1998, Biochemistry.

[53]  M. Kaplan,et al.  Decreased Neonatal Dietary Fat Absorption and T Cell Cytotoxicity in Pancreatic Lipase-related Protein 2-Deficient Mice* , 1998, The Journal of Biological Chemistry.

[54]  A. Nilsson,et al.  Digestion of ceramide by human milk bile salt-stimulated lipase. , 1998, Journal of pediatric gastroenterology and nutrition.

[55]  D. Lombardo,et al.  Participation of GRP94-related protein in secretion of pancreatic bile salt-dependent lipase and in its internalization by the intestinal epithelium. , 1998, Journal of cell science.

[56]  M. Polymeropoulos,et al.  Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21. , 1998, The Journal of clinical investigation.

[57]  A. Tall,et al.  Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[58]  R. Schekman,et al.  COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes , 1998, Cell.

[59]  C. Mansbach,et al.  Determinants of triacylglycerol transport from the endoplasmic reticulum to the Golgi in intestine. , 1997, The American journal of physiology.

[60]  J. Graham,et al.  Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes. , 1997, Journal of lipid research.

[61]  P. Tso,et al.  Ileal transposition into the upper jejunum affects lipid and bile salt absorption in rats. , 1996, The American journal of physiology.

[62]  D. Hui,et al.  Molecular biology of enzymes involved with cholesterol ester hydrolysis in mammalian tissues. , 1996, Biochimica et biophysica acta.

[63]  J. Rothman,et al.  Protein Sorting by Transport Vesicles , 1996, Science.

[64]  G. Taylor,et al.  Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia. , 1996, Atherosclerosis.

[65]  H. Gylling,et al.  The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level. , 1995, Atherosclerosis.

[66]  M. Lowe,et al.  Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion. , 1994, Gastroenterology.

[67]  M. Wilson,et al.  Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeys. , 1994, The Journal of clinical investigation.

[68]  M. Wilson,et al.  Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. , 1994, Journal of lipid research.

[69]  F. Field,et al.  Release of ceramide after membrane sphingomyelin hydrolysis decreases the basolateral secretion of triacylglycerol and apolipoprotein B in cultured human intestinal cells. , 1993, The Journal of clinical investigation.

[70]  D. Hui,et al.  Lipoamidase activity in normal and mutagenized pancreatic cholesterol esterase (bile salt-stimulated lipase). , 1993, The Biochemical journal.

[71]  R. Pagano,et al.  Inhibition of glycoprotein traffic through the secretory pathway by ceramide. , 1993, The Journal of biological chemistry.

[72]  D. Sviridov,et al.  Cholesterol uptake in the human intestine. Hypo- and hyperresponsiveness. , 1993, Biochimica et biophysica acta.

[73]  F. Field,et al.  Sphingomyelin content of intestinal cell membranes regulates cholesterol absorption. Evidence for pancreatic and intestinal cell sphingomyelinase activity. , 1992, The Biochemical journal.

[74]  D. Hui,et al.  Metabolic fate of pancreas-derived cholesterol esterase in intestine: an in vitro study using Caco-2 cells. , 1990, Journal of lipid research.

[75]  H. Hauser,et al.  Uptake of cholesterol by small intestinal brush border membrane is protein-mediated. , 1990, Biochemistry.

[76]  O. Hernell,et al.  Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings. , 1990, Biochemistry.

[77]  O. Hernell The Requirements and Utilization of Dietary Fatty Acids in the Newborn Infant , 1990, Acta paediatrica Scandinavica. Supplement.

[78]  P. Holt,et al.  A liquid crystalline phase in human intestinal contents during fat digestion , 1986, Lipids.

[79]  M. Ponz de Leòn,et al.  Cholesterol absorption in cirrhosis: the role of total and individual bile acid pool size. , 1981, Gastroenterology.

[80]  S. Sabesin,et al.  Electron microscopic studies of the assembly, intracellular transport, and secretion of chylomicrons by rat intestine. , 1977, Journal of lipid research.

[81]  L. Demers,et al.  Dynamics of the enterohepatic circulation of the glycine conjugates of cholic, chenodeoxycholic, deoxycholic, and sulfolithocholic acid in man. , 1977, Gastroenterology.

[82]  J. Dietschy,et al.  The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell. , 1976, The Journal of clinical investigation.

[83]  J. Dietschy,et al.  Regulation of cholesterol metabolism. , 1970, The New England journal of medicine.

[84]  B. Borgström Studies on intestinal cholesterol absorption in the human. , 1960 .

[85]  J. Hopper,et al.  Specific Function of Bile Salts in Cholesterol Absorption.∗ , 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[86]  K. Boberg,et al.  Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol , 2001 .

[87]  Anand K. Srivastava,et al.  Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption , 2001, Nature Genetics.

[88]  Charles R.scriver,et al.  The Metabolic basis of inherited disease , 1989 .

[89]  J. Larosa Review of clinical studies of bile acid sequestrants for lowering plasma lipid levels. , 1989, Cardiology.

[90]  L. V. van Zutphen,et al.  Hypo- and hyperresponders: individual differences in the response of serum cholesterol concentration to changes in diet. , 1987, Advances in lipid research.

[91]  C. Sylvén,et al.  The site of absorption of cholesterol and sitosterol in the rat small intestine. , 1970, Scandinavian journal of gastroenterology.