论文信息 - Novel synthesis of 1-aroyl-3-aryl-4-substituted imidazole-2-thiones.

Novel synthesis of 1-aroyl-3-aryl-4-substituted imidazole-2-thiones.

[reaction: see text] An efficient route to 1-aroyl-3-aryl-4-substituted imidazole-2-thiones (2, 4-6) has been developed. The methodology involves the cyclization of 1-aroyl-3-arylthioureas with a variety of carbonyl compounds bearing alpha-H in the presence of bromine and triethylamine.

Jun Chen | Qi Shen | Run-Sheng Zeng | Jian-Ping Zou | San-Jun Zhi

[1] G. Mugesh,et al. Reactions of Organoselenenyl Iodides with Thiouracil Drugs: An Enzyme Mimetic Study on the Inhibition of Iodothyronine Deiodinase. , 2001, Angewandte Chemie.

[2] J. Fuentes,et al. Fluoronucleosides, isothiocyanato C-nucleosides, and thioureylene di-C-nucleosides via cyclic sulfates. , 2002, The Journal of organic chemistry.

[3] P. Cintas,et al. Non-biaryl atropisomers derived from carbohydrates. Part 1. Stereoselective synthesis of 1-aryl-5-hydroxyimidazolidine-2-thiones and their transformation into imidazoline-2-thiones☆ , 1999 .

[4] Consolación Gasch,et al. Chiral thioxohydroimidazoles with two sugar moieties. N-, C-, and spiro-nucleosides , 2000 .

[5] Y. Isomura,et al. One-Pot Preparation of 1-Substituted Imidazole-2-thione from Isothiocyanate and Amino Acetal , 1997 .

[6] C. Rimington,et al. 489. 2-Mercaptoglyoxalines. Part II. Application of the mannich reaction. Protection of the thiol group , 1951 .

[7] K. Chen,et al. PREPARATION OF 2,4-IMIDAZOLIDINEDIONES (HYDANTOINS) FROM ALPHA -KETO HEMITHIOACETAL AND UREAS , 1996 .

[8] A. Lawson,et al. 671. 2-Mercaptoglyoxalines. Part V. The preparation of 4(5)-substituted 2-mercaptoglyoxalines from amino-acids , 1951 .

[9] A. Wohl,et al. Ueber Condensationsproducte aus Amidoacetal. I , 1889 .

[10] W. Marckwald. Ein Beitrag zur Kenntniss der Imidazole und der Constitution des Glyoxalins , 1892 .