Biomimetics for the induction of bone formation

The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-β supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.

[1]  J. Jansen,et al.  Thin Calcium Phosphate Coatings for Medical Implants , 2009 .

[2]  L. Roden,et al.  The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs. , 2009, Biomaterials.

[3]  U. Ripamonti.  Biomimetism, biomimetic matrices and the induction of bone formation , 2008, Journal of cellular and molecular medicine.

[4]  Clemens A van Blitterswijk,et al.  The effect of calcium phosphate microstructure on bone-related cells in vitro. , 2008, Biomaterials.

[5]  U. Ripamonti,et al.  The induction of endochondral bone formation by transforming growth factor-β3: experimental studies in the non-human primate Papio ursinus , 2008, Journal of cellular and molecular medicine.

[6]  U. Ripamonti,et al.  The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus , 2008, Journal of cellular and molecular medicine.

[7]  Peter Fratzl,et al.  The effect of geometry on three-dimensional tissue growth , 2008, Journal of The Royal Society Interface.

[8]  D. Chappard,et al.  Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model. , 2008, Biomaterials.

[9]  P. W. Richter,et al.  Self-Inducing Shape Memory Geometric Cues Embedded within Smart Hydroxyapatite-Based Biomimetic Matrices , 2007, Plastic and reconstructive surgery.

[10]  Ugo Ripamonti,et al.  Bone morphogenetic proteins and the induction of bone formation: from laboratory to patients. , 2007, Oral and maxillofacial surgery clinics of North America.

[11]  B. Zheng,et al.  Prospective identification of myogenic endothelial cells in human skeletal muscle , 2007, Nature Biotechnology.

[12]  Peter Fratzl,et al.  Biomimetic materials research: what can we really learn from nature's structural materials? , 2007, Journal of The Royal Society Interface.

[13]  Michel Kerszberg,et al.  Specifying Positional Information in the Embryo: Looking Beyond Morphogens , 2007, Cell.

[14]  P. Fratzl,et al.  Three-dimensional growth behavior of osteoblasts on biomimetic hydroxylapatite scaffolds. , 2007, Journal of biomedical materials research. Part A.

[15]  Arthur D Lander,et al.  Morpheus Unbound: Reimagining the Morphogen Gradient , 2007, Cell.

[16]  David Butler,et al.  Tissue engineering and developmental biology: going biomimetic. , 2006, Tissue engineering.

[17]  M. Heliotis,et al.  Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development , 2006, Journal of anatomy.

[18]  C. V. van Blitterswijk,et al.  Cross-species comparison of ectopic bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) scaffolds. , 2006, Tissue engineering.

[19]  Clemens A van Blitterswijk,et al.  Osteoinduction by biomaterials--physicochemical and structural influences. , 2006, Journal of biomedical materials research. Part A.

[20]  U. Ripamonti.  Soluble osteogenic molecular signals and the induction of bone formation. , 2006, Biomaterials.

[21]  G. Daculsi,et al.  Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles. , 2005, Bone.

[22]  U. Ripamonti.  Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues , 2004, Journal of cellular and molecular medicine.

[23]  J. Davies,et al.  Use of a biomimetic strategy to engineer bone. , 2003, Journal of biomedical materials research. Part A.

[24]  A. Reddi,et al.  Long‐Term Evaluation of Bone Formation by Osteogenic Protein 1 in the Baboon and Relative Efficacy of Bone‐Derived Bone Morphogenetic Proteins Delivered by Irradiated Xenogeneic Collagenous Matrices , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[25]  A. Reddi,et al.  Morphogenesis and tissue engineering of bone and cartilage: inductive signals, stem cells, and biomimetic biomaterials. , 2000, Tissue engineering.

[26]  Xing‐dong Zhang,et al.  Tissue responses of calcium phosphate cement: a study in dogs. , 2000, Biomaterials.

[27]  A. Reddi,et al.  Role of morphogenetic proteins in skeletal tissue engineering and regeneration , 1998, Nature Biotechnology.

[28]  H. Ohgushi,et al.  BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis. , 1998, Journal of biomedical materials research.

[29]  J. Jansen,et al.  Calcium phosphate coatings for medical implants , 1998, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[30]  A. Reddi.  Bone Morphogenesis and Modeling: Soluble Signals Sculpt Osteosomes in the Solid State , 1997, Cell.

[31]  U. Ripamonti,et al.  Tissue Engineering of Bone by Osteoinductive Biomaterials , 1996 .

[32]  R. Jilka,et al.  Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. , 1995, The New England journal of medicine.

[33]  A. Reddi.  Symbiosio of biotechnology and biomaterials: Applications in tissue engineering of bone and cartilage , 1994, Journal of cellular biochemistry.

[34]  A. Parfitt.  Osteonal and hemi‐osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone , 1994, Journal of cellular biochemistry.

[35]  U. Ripamonti,et al.  Expression of the osteogenic phenotype in porous hydroxyapatite implanted extraskeletally in baboons. , 1993, Matrix.

[36]  H. Kleinman,et al.  Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen , 1992, The Journal of cell biology.

[37]  A. Reddi,et al.  The critical role of geometry of porous hydroxyapatite delivery system in induction of bone by osteogenin, a bone morphogenetic protein. , 1992, Matrix.

[38]  H. Reddi,et al.  Tissue transformation into bone in vivo. A potential practical application. , 1991, JAMA.

[39]  U. Ripamonti,et al.  The morphogenesis of bone in replicas of porous hydroxyapatite obtained from conversion of calcium carbonate exoskeletons of coral. , 1991, The Journal of bone and joint surgery. American volume.

[40]  Frank P. Luyten,et al.  Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: Regulation by discrete domains of laminin , 1990, Cell.

[41]  H. Kleinman,et al.  Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. , 1990, The Journal of biological chemistry.

[42]  E. Drier,et al.  OP‐1 cDNA encodes an osteogenic protein in the TGF‐beta family. , 1990, The EMBO journal.

[43]  V. Rosen,et al.  Novel regulators of bone formation: molecular clones and activities. , 1988, Science.

[44]  D. Ingber,et al.  A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane. , 1988, The American journal of pathology.

[45]  A. Reddi,et al.  Importance of geometry of the extracellular matrix in endochondral bone differentiation , 1984, The Journal of cell biology.

[46]  A. Reddi,et al.  Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[47]  A. Reddi,et al.  Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[48]  J. Folkman,et al.  Influence of geometry on control of cell growth. , 1975, Biochimica et biophysica acta.

[49]  A. Reddi,et al.  Influence of Geometry of Transplanted Tooth and Bone on Transformation of Fibroblasts 1 , 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[50]  M. Urist,et al.  The bone induction principle. , 1967, Clinical orthopaedics and related research.

[51]  M. Urist,et al.  Bone: Formation by Autoinduction , 1965, Science.

[52]  J. Trueta,et al.  The role of the vessels in osteogenesis , 1963 .

[53]  A. M. Turing,et al.  The chemical basis of morphogenesis , 1952, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[54]  R. R. Bensley,et al.  Embryonic Development and Induction , 1938, The Yale Journal of Biology and Medicine.

[55]  Pamela Habibovic,et al.  Osteoinductive biomaterials—properties and relevance in bone repair , 2007, Journal of tissue engineering and regenerative medicine.

[56]  U. Ripamonti,et al.  Soluble Signals and Insoluble Substrata , 2004 .

[57]  U. Ripamonti.  Osteogenic Proteins of the TGF-β Superfamily , 2003 .

[58]  Huipin Yuan,et al.  Bone formation induced by calcium phosphate ceramics in soft tissue of dogs: a comparative study between porous α-TCP and β-TCP , 2001, Journal of materials science. Materials in medicine.

[59]  A. Kirkbride,et al.  SINTERED POROUS HYDROXYAPATITES WITH INTRINSIC OSTEOINDUCTIVE ACTIVITY: GEOMETRIC INDUCTION OF BONE FORMATION , 1999 .

[60]  U. Ripamonti,et al.  Tissue morphogenesis and regeneration by bone morphogenetic proteins. , 1998, Plastic and reconstructive surgery.

[61]  A. Poole,et al.  Two distinctive BMP-carriers induce zonal chondrogenesis and membranous ossification, respectively; geometrical factors of matrices for cell-differentiation. , 1995, Connective tissue research.

[62]  S. Manolagas.  Bone marrow, cytokines, and bone remodeling , 1995 .

[63]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[64]  A. Reddi,et al.  Extracellular matrix biochemistry , 1984 .

[65]  A. Reddi.  Bone matrix in the solid state: geometric influence on differentiation of fibroblasts. , 1974, Advances in biological and medical physics.

[66]  G. Levander.  Tissue Induction , 1945, Nature.