Evaluation of the hemostatic potential including thrombin generation of three different therapeutic pathogen‐reduced plasmas

Background and Objectives  Several pathogen inactivation methods currently applied to therapeutic plasma may result in products with different hemostatic properties. This study aims at evaluating and comparing the hemostatic potential of different therapeutic plasma preparations currently available in France.

[1]  B. Horowitz,et al.  Virus Inactivation by Solvent/Detergent Treatment and the Manufacture of SD‐Plasma , 1998, Vox sanguinis.

[2]  H. Coenraad Hemker,et al.  Calibrated Automated Thrombin Generation Measurement in Clotting Plasma , 2003, Pathophysiology of Haemostasis and Thrombosis.

[3]  J. Seghatchian,et al.  Updates on pathogen inactivation of plasma using Theraflex methylene blue system. , 2008, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[4]  R. van Oerle,et al.  Coagulation factors and the protein C system as determinants of thrombin generation in a normal population , 2007, Journal of thrombosis and haemostasis : JTH.

[5]  G. Rock,et al.  ADAMTS-13 levels in fresh, stored, and solvent detergent treated plasma. , 2006, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[6]  L. Green,et al.  The effect of prion reduction in solvent/detergent‐treated plasma on haemostatic variables , 2010, Vox sanguinis.

[7]  C. Boulat,et al.  Évolution des indications et de la consommation du plasma frais congelé de 1997 à 2003 dans un hôpital universitaire , 2005 .

[8]  B. Châtelain,et al.  Coagulation function in fresh‐frozen plasma prepared with two photochemical treatment methods: methylene blue and amotosalen , 2007, Transfusion.

[9]  D. Benhamou.  The use of Fresh Frozen Plasma (FFP) in 2007 in France. , 2007, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

[10]  P. Hellstern,et al.  Manufacture and composition of fresh frozen plasma and virus-inactivated therapeutic plasma preparations: correlation between composition and therapeutic efficacy. , 2002, Thrombosis research.

[11]  J. Mateo,et al.  Methylene blue‐photoinactivated plasma versus quarantine fresh frozen plasma in thrombotic thrombocytopenic purpura: a multicentric, prospective cohort study , 2008, British journal of haematology.

[12]  C. Boulat,et al.  [Evolution of indications and consumptions of fresh frozen plasma from 1997 to 2003 in a teaching Hospital]. , 2005, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

[13]  F. Depasse,et al.  The influence of methylene blue light treatment and methylene blue removal filter on fibrinogen activity states and fibrin polymerisation indices. , 2005, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[14]  Flora Peyvandi,et al.  The Thrombogram in Rare Inherited Coagulation Disorders: Its Relation to Clinical Bleeding , 2002, Thrombosis and Haemostasis.

[15]  C. Prowse,et al.  The effect of methylene blue photoinactivation and methylene blue removal on the quality of fresh‐frozen plasma , 2003, Transfusion.

[16]  J. Lundahl,et al.  Coagulation parameters in apheresis and leukodepleted whole‐blood plasma during storage , 2007, Transfusion.

[17]  F. Depasse,et al.  Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay , 2005, Thrombosis journal.

[18]  B. Baron,et al.  Study of three patients with thrombotic thrombocytopenic purpura exchanged with solvent/detergent‐treated plasma: Is its decreased protein S activity clinically related to their development of deep venous thromboses? , 2000, Journal of clinical apheresis.

[19]  A. Humpe,et al.  Filtration of methylene blue‐photooxidized plasma: influence on coagulation and cellular contamination , 2001, Transfusion.

[20]  J. Pelletier,et al.  Pathogen inactivation techniques☆ , 2005, Best Practice & Research Clinical Haematology.

[21]  C. Négrier,et al.  Use of calibrated automated thrombinography ± thrombomodulin to recognise the prothrombotic phenotype , 2006, Thrombosis and Haemostasis.

[22]  L. Sawyer,et al.  Photochemical treatment of plasma with amotosalen and long‐wavelength ultraviolet light inactivates pathogens while retaining coagulation function , 2006, Transfusion.

[23]  N. Key,et al.  Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram , 2009, Thrombosis and Haemostasis.

[24]  T. Hervig,et al.  Photochemical treatment of plasma with amotosalen and UVA light: process validation in three European blood centers , 2008, Transfusion.

[25]  R. Cardigan,et al.  The characterization and impact of microparticles on haemostasis within fresh‐frozen plasma , 2008, Vox sanguinis.

[26]  R. Cardigan,et al.  The dynamics of clot formation in fresh‐frozen plasma , 2008, Vox sanguinis.

[27]  M. Quadroni,et al.  Proteomics of methylene blue photo‐treated plasma before and after removal of the dye by an absorbent filter , 2004, Proteomics.

[28]  J. Römisch,et al.  A biochemical comparison of a pharmaceutically licensed coagulation active plasma (Octaplas) with a universally applicable development product (Uniplas) and single-donor FFPs subjected to methylene-blue dye and white-light treatment. , 2006, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[29]  K. Mann,et al.  "Normal" thrombin generation. , 1999, Blood.

[30]  J. Römisch,et al.  Thrombin generation capacity is impaired in methylene-blue treated plasma compared to normal levels in single-donor fresh-frozen plasma, a licensed solvent/detergent-treated plasma (Octaplas) and a development product (Uniplas). , 2007, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[31]  R. Cardigan,et al.  Thrombin generation and clot formation in methylene blue–treated plasma and cryoprecipitate , 2009, Transfusion.

[32]  J. Cid,et al.  Quantitative and qualitative analysis of proteins in fresh frozen plasma obtained from whole blood donations and prepared with two photochemical treatments. , 2008, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[33]  J. Montoro,et al.  Influence of Methylene Blue Photoinactivation Treatment on Coagulation Factors from Fresh Frozen Plasma, Cryoprecipitates and Cryosupernatants , 2000, Vox Sanguinis.

[34]  B. Pan-petesch,et al.  Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma , 2008, Thrombosis and Haemostasis.