Genetic influences on prepulse inhibition of startle reflex in humans

Prepulse inhibition (PPI) is a suppression of the startle reflex that occurs when an intense startling stimulus is preceded by a weaker 'prepulse' stimulus. PPI deficits have been implicated in the biological bases of schizophrenia and some other neuropsychiatric disorders and proposed as a possible biological marker (endophenotype) for genetic studies. However, little is known about the genetic determination of PPI in humans. We examined acoustic eye-blink startle reflex and PPI in 142 young female twins (40 monozygotic and 31 dizygotic pairs) and conducted a biometrical genetic analysis using structural equation modeling. PPI showed significant heritability suggesting that over 50% of PPI variance in this sample can be attributed to genetic factors. Baseline startle magnitude showed higher heritability (about 70%).

[1]  Anne M. Spence,et al.  Identification of quantitative trait loci for prepulse inhibition in rats , 2002, Psychopharmacology.

[2]  C. Grillon,et al.  Startle modulation in children at risk for anxiety disorders and/or alcoholism. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[3]  L. Eaves,et al.  The zygosity of twins: further evidence on the agreement between diagnosis by blood groups and written questionnaires , 1976, Journal of Biosocial Science.

[4]  N. Swerdlow,et al.  Genetic differences in startle gating-disruptive effects of apomorphine: evidence for central mediation. , 2002, Behavioral neuroscience.

[5]  D. Feifel.  Individual differences in prepulse inhibition of startle as a measure of individual dopamine function. , 1999, Behavioral neuroscience.

[6]  M. Geyer,et al.  Prepulse startle deficit in the Brown Norway rat: a potential genetic model. , 2000, Behavioral neuroscience.

[7]  J. Crawley,et al.  Inbred strain differences in prepulse inhibition of the mouse startle response , 1997, Psychopharmacology.

[8]  M. Geyer.  Assessing prepulse inhibition of startle in wild-type and knockout mice , 1999, Psychopharmacology.

[9]  W. Iacono,et al.  Emotional modulation of the startle reflex in twins: preliminary findings , 1997, Biological Psychology.

[10]  N. Swerdlow,et al.  Changes in sensorimotor inhibition across the menstrual cycle: Implications for neuropsychiatric disorders , 1997, Biological Psychiatry.

[11]  A. C. Collins,et al.  Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response. , 1997, Behavioral neuroscience.

[12]  David A. Smith,et al.  Test-retest reliability of prepulse inhibition of the acoustic startle response , 1993, Biological Psychiatry.

[13]  D L Braff,et al.  Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. , 2000, The American journal of psychiatry.

[14]  Michael C. Neale,et al.  Methodology for Genetic Studies of Twins and Families , 1992 .

[15]  T. Palfai,et al.  Prepulse inhibition of the startle reflex: preliminary study of the effects of a low dose of alcohol in humans. , 1997, Alcoholism, clinical and experimental research.

[16]  Kristin S Cadenhead,et al.  Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population , 1999, Biological Psychiatry.

[17]  Pak Chung Sham,et al.  Analytic approaches to twin data using structural equation models , 2002, Briefings Bioinform..