CD4 T cells: fates, functions, and faults.
暂无分享,去创建一个
[1] Richard A Flavell,et al. The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.
[2] W. Paul,et al. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4- producing cells , 1990, The Journal of experimental medicine.
[3] Hua Yu,et al. Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity1 , 2007, The Journal of Immunology.
[4] Yuelei Shen,et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function , 2008, Nature.
[5] Ian A. White,et al. An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[6] Y. Belkaid,et al. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity , 2002, Nature.
[7] Jonathan A. Bernstein,et al. V75R576 IL-4 Receptor α Is Associated with Allergic Asthma and Enhanced IL-4 Receptor Function1 , 2002, The Journal of Immunology.
[8] Hervé Groux,et al. A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.
[9] A. Al-ghonaium,et al. Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds. , 2002, American journal of human genetics.
[10] L. Glimcher,et al. Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression , 2002, The Journal of experimental medicine.
[11] E. Chi,et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. , 2008, Immunity.
[12] D. Levy,et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways , 2007, Nature Immunology.
[13] R. Döffinger,et al. In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma. , 2000, The Journal of clinical investigation.
[14] Y. Wan,et al. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. , 2007, Immunity.
[15] A. Mantovani,et al. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. , 1998, Journal of immunology.
[16] Richard A Flavell,et al. Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells , 2004, Cell.
[17] J. Rioux,et al. T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. , 2006, American journal of respiratory and critical care medicine.
[18] R. Kelley,et al. IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor binding , 2001, The EMBO journal.
[19] S. Sa,et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.
[20] K. Sugamura,et al. Selective expression of a novel surface molecule by human Th2 cells in vivo. , 1999, Journal of immunology.
[21] Lars Rogge,et al. Faculty Opinions recommendation of IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. , 2008 .
[22] A. D. Panopoulos,et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells , 2007, Nature.
[23] R. Schreiber,et al. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. , 1988, Science.
[24] Richard A. Flavell,et al. Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection , 2007, The Journal of experimental medicine.
[25] Kathleen M. Smith,et al. Development, cytokine profile and function of human interleukin 17–producing helper T cells , 2007, Nature Immunology.
[26] W. Paul,et al. Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment , 2005, The Journal of experimental medicine.
[27] M. Kaplan,et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.
[28] K. Furuuchi,et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer , 2008, Nature Immunology.
[29] W. Ouyang,et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. , 1998, Immunity.
[30] K. Boyd,et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function , 2007, Nature.
[31] S. Szabo,et al. Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet , 2002, Science.
[32] Ying Wang,et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 , 2005, Nature Immunology.
[33] H. Weiner,et al. Th3 Cells in Peripheral Tolerance. I. Induction of Foxp3-Positive Regulatory T Cells by Th3 Cells Derived from TGF-β T Cell-Transgenic Mice1 , 2007, The Journal of Immunology.
[34] H. Takada,et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome , 2007, Nature.
[35] M. Grusby,et al. IL-21 Inhibits IFN-γ Production in Developing Th1 Cells through the Repression of Eomesodermin Expression1 , 2006, The Journal of Immunology.
[36] Warren Strober,et al. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet. , 2003, Immunity.
[37] E. Shevach,et al. Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells , 2007, The Journal of Immunology.
[38] C. Mackay,et al. Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes , 1998, The Journal of experimental medicine.
[39] T. Mosmann,et al. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones , 1989, The Journal of experimental medicine.
[40] T. Morio,et al. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. , 2006, Immunity.
[41] Booki Min,et al. Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. , 2002, Immunity.
[42] M. Newport,et al. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. , 1996, The New England journal of medicine.
[43] D. Carbone,et al. Adenosine receptors in regulation of dendritic cell differentiation and function. , 2008, Blood.
[44] D. Littman,et al. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.
[45] A. Tyznik,et al. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells , 2006, Nature.
[46] E. Shevach. From vanilla to 28 flavors: multiple varieties of T regulatory cells. , 2006, Immunity.
[47] W. Paul,et al. Stat5 activation plays a critical role in Th2 differentiation. , 2003, Immunity.
[48] Christopher A Hunter,et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 , 2007, Nature Immunology.
[49] A. Sher,et al. Cooperation of Toll-like receptor signals in innate immune defence , 2007, Nature Reviews Immunology.
[50] M. Baggiolini,et al. CCR5 is characteristic of Th1 lymphocytes , 1998, Nature.
[51] Terry B. Strom,et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells , 2007, Nature.
[52] W. Paul,et al. Lymphocyte responses and cytokines , 1994, Cell.
[53] T. Mak,et al. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4 , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[54] M. Farrar,et al. IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 , 2007, The Journal of Immunology.
[55] A. Sher,et al. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[56] Fiona Powrie,et al. An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation , 1999, The Journal of experimental medicine.
[57] Anjana Rao,et al. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells , 2007, Nature Immunology.
[58] Niamh E Mangan,et al. Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion , 2006, The Journal of experimental medicine.
[59] W. Ouyang,et al. IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production. , 2001, Nature immunology.
[60] A Radbruch,et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. , 2000, Immunity.
[61] P. Doherty,et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells , 1996, Nature.
[62] W. Paul,et al. GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors , 2006, Cell Research.
[63] Booki Min,et al. Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses , 2004, Nature Immunology.
[64] S. Akira,et al. Essential role of Stat6 in IL-4 signalling , 1996, Nature.
[65] W. Paul,et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.
[66] J. Casanova,et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy , 2001, Nature Genetics.
[67] K. Ihara,et al. Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis. , 1999, Journal of immunology.
[68] W. Leonard,et al. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation , 2005, Nature Reviews Immunology.
[69] S. Pai,et al. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[70] P. Lipsky,et al. GATA-3 in Human T Cell Helper Type 2 Development , 2004, The Journal of experimental medicine.
[71] R. Flavell,et al. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions , 2005, Nature Immunology.
[72] A. Caudy,et al. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. , 2007, The Journal of allergy and clinical immunology.
[73] Rajesh V. Thakker,et al. GATA3 haplo-insufficiency causes human HDR syndrome , 2000, Nature.
[74] R. J. Hocking,et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.
[75] K. Murphy,et al. Th17: an effector CD4 T cell lineage with regulatory T cell ties. , 2006, Immunity.
[76] E. Barillot,et al. A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses , 2008, Nature Immunology.
[77] T. Nomura,et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 , 2007, Nature.
[78] A. Kulkarni,et al. A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells , 2008, Nature Immunology.
[79] R. Chakraborty,et al. V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. , 2002, Journal of immunology.
[80] A. Woods,et al. Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells. , 1987, Journal of immunology.
[81] M. Farrar,et al. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. , 2008, Immunity.
[82] R. Flavell,et al. Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression , 2000, The Journal of Immunology.
[83] Dragana Jankovic,et al. Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion , 2006, Proceedings of the National Academy of Sciences.
[84] J. Stroud,et al. FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT , 2006, Cell.
[85] W. Leonard,et al. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines , 2000, Oncogene.
[86] Martin Bachmann,et al. Disruption of the murine IL-4 gene blocks Th2 cytokine responses , 1993, Nature.
[87] Mario Roederer,et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major , 2007, Nature Medicine.
[88] Li Li,et al. Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.
[89] L. Glimcher,et al. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. , 1999, Immunity.
[90] A. Rudensky,et al. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 , 2007, Nature Immunology.
[91] Sonia Jain,et al. Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. , 2008, Blood.
[92] Yuka Kanno,et al. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription , 2006, The Journal of experimental medicine.
[93] Yong‐jun Liu,et al. Interleukin 25 promotes the initiation of proallergic type 2 responses , 2007, The Journal of experimental medicine.
[94] H. Lee,et al. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. , 1999, Immunity.
[95] A. Murphy,et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. , 2007, Immunity.
[96] Jianfei Yang,et al. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells , 2002, Nature Immunology.
[97] D. Patel,et al. Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse. , 2001, The Journal of clinical investigation.
[98] S. Wenzel,et al. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. , 1999, The Journal of clinical investigation.
[99] D. Jarrossay,et al. Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells , 2007, Nature Immunology.
[100] M. Leach,et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. , 2001, Immunity.
[101] W. Miller,et al. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. , 2000, Science.
[102] R. Flavell,et al. Interchromosomal associations between alternatively expressed loci , 2005, Nature.
[103] Pamela L. Schwartzberg,et al. T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3 , 2005, Science.
[104] R. Flavell,et al. Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms , 2006 .
[105] D. Galas,et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse , 2001, Nature Genetics.
[106] P. Allavena,et al. Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s , 1998, The Journal of experimental medicine.
[107] H. Weiner,et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. , 1994, Science.
[108] Nonredundant roles for Stat5a/b in directly regulating Foxp3. , 2007, Blood.
[109] Sami Al-Hajjar,et al. Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. , 2003, The Journal of experimental medicine.
[110] Albert Bendelac,et al. The biology of NKT cells. , 2007, Annual review of immunology.
[111] A. Weinberg,et al. IL-4 directs the development of Th2-like helper effectors. , 1990, Journal of immunology.
[112] J. Kere,et al. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. , 2005, The Journal of allergy and clinical immunology.
[113] N. Hamasaki,et al. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. , 1998, Nature genetics.
[114] D. Sacks,et al. CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis , 2007, The Journal of experimental medicine.
[115] Anjana Rao,et al. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. , 2002, Immunity.
[116] Z. Estrov,et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. , 2008, Blood.
[117] R. Flavell,et al. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. , 2004, Immunity.
[118] P. Carmeliet,et al. Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles. , 2008, Blood.
[119] R. D. Hatton,et al. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages , 2005, Nature Immunology.
[120] W. Paul,et al. Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13. , 2005, Immunity.
[121] T. Mcclanahan,et al. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology , 2007, Nature Immunology.
[122] F. Finkelman,et al. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. , 1998, Immunity.
[123] H. Weiner,et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.
[124] Chen Dong,et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. , 2008, Immunity.
[125] J Fernando Bazan,et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. , 2005, Immunity.
[126] J. Buer,et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins , 2008, Nature.
[127] G. Henkel,et al. A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. , 1992, Journal of immunology.
[128] Sami Al-Hajjar,et al. Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor β1 Deficiency , 2003, The Journal of Experimental Medicine.
[129] Dustin E. Schones,et al. High-Resolution Profiling of Histone Methylations in the Human Genome , 2007, Cell.
[130] A. Sher,et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[131] A. Bowcock,et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. , 2000, The Journal of clinical investigation.
[132] R. Kastelein,et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. , 1997, Immunity.
[133] D. Littman,et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. , 2006, Cell.
[134] S. Tangye,et al. STAT3 is required for IL-21-induced secretion of IgE from human naive B cells. , 2008, Blood.
[135] T. Nomura,et al. Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .
[136] K. Honda,et al. The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells , 2008, Nature Immunology.
[137] Alf Hamann,et al. Expression of the integrin αEβ7 identifies unique subsets of CD25+ as well as CD25− regulatory T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[138] Vincent C. Manganiello,et al. Foxp3-dependent programme of regulatory T-cell differentiation , 2007, Nature.
[139] D. Littman,et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer , 2007, The Journal of experimental medicine.
[140] D. G. Zisoulis,et al. Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1 , 2007, The Journal of Immunology.
[141] S. Sakaguchi. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. , 2004, Annual review of immunology.
[142] K. Mills,et al. A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis , 2006, The Journal of experimental medicine.
[143] R. Coffman,et al. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.
[144] R. D. Hatton,et al. Transforming growth factor-beta induces development of the T(H)17 lineage. , 2006, Nature.
[145] C. Brosnan,et al. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. , 1991, The Journal of clinical investigation.
[146] C. Mackay,et al. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. , 1997, Science.
[147] A. Rudensky,et al. TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells , 2005, The Journal of experimental medicine.
[148] F. Finkelman,et al. Stat6 Regulation of In Vivo IL-4 Responses1 , 2000, The Journal of Immunology.
[149] T. Wynn. IL-13 effector functions. , 2003, Annual review of immunology.
[150] J. Casanova,et al. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. , 1998, Science.
[151] T. Gingeras,et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells , 2006, The Journal of experimental medicine.
[152] T. Chatila,et al. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. , 1997, The New England journal of medicine.
[153] Hao Shen,et al. Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin , 2003, Science.
[154] A. Sher,et al. Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile , 2000, The Journal of Immunology.
[155] Edward M. Rubin,et al. Deletion of a coordinate regulator of type 2 cytokine expression in mice , 2001, Nature Immunology.
[156] F. Sallusto,et al. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. , 2007, Nature immunology.
[157] M. Toda,et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.
[158] A. Ray,et al. Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene* , 1997, The Journal of Biological Chemistry.
[159] O. Joffre,et al. Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes , 2008, Nature Medicine.
[160] W. Paul,et al. Basophils Produce IL-4 and Accumulate in Tissues after Infection with a Th2-inducing Parasite , 2004, The Journal of experimental medicine.
[161] Li V. Yang,et al. Amphiregulin, a TH2 Cytokine Enhancing Resistance to Nematodes , 2006, Science.
[162] L. Chodosh,et al. Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction , 2002, Nature Immunology.
[163] P. Valdez,et al. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis , 2007, Nature.
[164] M. Kaplan,et al. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.
[165] M. Fei,et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia , 2008, Nature Medicine.
[166] L. Hennighausen,et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. , 2007, Immunity.
[167] B. Thiers,et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major , 2008 .
[168] W. Paul,et al. Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion , 2001, The Journal of Immunology.
[169] R. Coffman,et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.
[170] C. Hsieh,et al. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. , 1993, Science.
[171] W. Ouyang,et al. IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production , 2001, Nature Immunology.
[172] P. Hjelmström,et al. A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis , 1997, The Journal of experimental medicine.
[173] Judy H. Cho,et al. A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene , 2006, Science.
[174] A. Rudensky,et al. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.
[175] F. Powrie,et al. Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-101 , 2003, The Journal of Immunology.
[176] T. Mak,et al. The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 , 2007, Nature Immunology.
[177] Bodo Grimbacher,et al. STAT3 mutations in the hyper-IgE syndrome. , 2007, The New England journal of medicine.
[178] R. Coffman,et al. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. , 1989, Science.
[179] A. Scheffold,et al. Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[180] R. Flavell,et al. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. , 2006, Immunity.
[181] W. Paul,et al. Interleukin 2 plays a central role in Th2 differentiation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[182] R. Kastelein,et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain , 2003, Nature.
[183] R. Coffman,et al. Interleukin-10 and the interleukin-10 receptor. , 2001, Annual review of immunology.
[184] Y. Wan,et al. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression , 2007, Nature.
[185] J. Berzofsky. Faculty Opinions recommendation of TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. , 2007 .
[186] Laurie H Glimcher,et al. A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.
[187] R. Kastelein,et al. IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB , 1997 .
[188] R. Flavell,et al. Demethylation of a specific hypersensitive site in the Th2 locus control region , 2007, Proceedings of the National Academy of Sciences.
[189] M. Newport,et al. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. , 1996, The New England journal of medicine.