An integrative review of attention biases and their contribution to treatment for anxiety disorders

Models of exposure therapy, one of the key components of cognitive behavioral therapy for anxiety disorders, suggest that attention may play an important role in the extinction of fear and anxiety. Evidence from cognitive research suggests that individual differences may play a causal role in the onset and maintenance of anxiety disorders and so it is also likely to influence treatment. We review the evidence concerning attention and treatment outcomes in anxiety disorders. The evidence reviewed here suggests that that attention biases assessed at pre-treatment might actually predict improved response to treatment, and in particular that prolonged engagement with threat as measured in tasks such as the dot probe is associated with greater reductions in anxious symptoms following treatment. We examine this research within a fear learning framework, considering the possible role of individual differences in attention in the extinction of fear during exposure. Theoretical, experimental and clinical implications are discussed, particularly with reference to the potential for attention bias modification programs in augmenting treatment, and also with reference to how existing research in this area might inform best practice for clinicians.

[1]  Murray B Stein,et al.  Anxiety , 2017, The Lancet.

[2]  Y. Bar-Haim,et al.  Content specificity of attention bias to threat in anxiety disorders: a meta-analysis. , 2015, Clinical psychology review.

[3]  I. Krejtz,et al.  Orienting and maintenance of attention to threatening facial expressions in anxiety – An eye movement study , 2014, Psychiatry Research.

[4]  Jennifer Webb-Murphy,et al.  The effectiveness of an attention bias modification program as an adjunctive treatment for Post-Traumatic Stress Disorder. , 2014, Behaviour research and therapy.

[5]  Karin Mogg,et al.  Augmenting one-session treatment of children's specific phobias with attention training to positive stimuli. , 2014, Behaviour research and therapy.

[6]  Matthias M. Müller,et al.  Snake fearfulness is associated with sustained competitive biases to visual snake features: Hypervigilance without avoidance , 2014, Psychiatry Research.

[7]  G. Crombez,et al.  A review of current evidence for the causal impact of attentional bias on fear and anxiety. , 2014, Psychological bulletin.

[8]  Greg J Siegle,et al.  LOOKING UNDER THE HOOD OF THE DOT‐PROBE TASK: AN fMRI STUDY IN ANXIOUS YOUTH , 2014, Depression and anxiety.

[9]  A. Öhman,et al.  Attention biases and habituation of attention biases are associated with 5-HTTLPR and COMTval158met , 2014, Cognitive, affective & behavioral neuroscience.

[10]  Ioana R. Podina,et al.  Optimal attentional focus during exposure in specific phobia: a meta-analysis. , 2013, Clinical psychology review.

[11]  A. Jansen,et al.  Neural substrates of treatment response to cognitive-behavioral therapy in panic disorder with agoraphobia. , 2013, The American journal of psychiatry.

[12]  Matthew D. Lieberman,et al.  Attentional bias and emotional reactivity as predictors and moderators of behavioral treatment for social phobia. , 2013, Behaviour research and therapy.

[13]  N. Amir,et al.  AUGMENTATION OF YOUTH COGNITIVE BEHAVIORAL AND PHARMACOLOGICAL INTERVENTIONS WITH ATTENTION MODIFICATION: A PRELIMINARY INVESTIGATION , 2013, Depression and anxiety.

[14]  Adam Hemminger,et al.  Attentional bias in injection phobia: overt components, time course, and relation to behavior. , 2013, Behaviour research and therapy.

[15]  R. Rapee,et al.  Integrating cognitive bias modification into a standard cognitive behavioural treatment package for social phobia: a randomized controlled trial. , 2013, Behaviour research and therapy.

[16]  A. Toga,et al.  FKBP5 and attention bias for threat: associations with hippocampal function and shape. , 2013, JAMA psychiatry.

[17]  Gang Chen,et al.  Training-associated changes and stability of attention bias in youth: Implications for Attention Bias Modification Treatment for pediatric anxiety , 2013, Developmental Cognitive Neuroscience.

[18]  N. Berggren,et al.  Attentional control deficits in trait anxiety: Why you see them and why you don’t , 2013, Biological Psychology.

[19]  Moriel Zelikowsky,et al.  Cholinergic Blockade Frees Fear Extinction from Its Contextual Dependency , 2013, Biological Psychiatry.

[20]  Thalia C Eley,et al.  Therapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disorders , 2013, Biology of Mood & Anxiety Disorders.

[21]  G. Crombez,et al.  Conditioned fear modulates visual selection. , 2013, Emotion.

[22]  Thomas Armstrong,et al.  Eye tracking of attention in the affective disorders: a meta-analytic review and synthesis. , 2012, Clinical psychology review.

[23]  Alice T. Sawyer,et al.  Efficacy of attention bias modification using threat and appetitive stimuli: a meta-analytic review. , 2012, Behavior therapy.

[24]  Charles T. Taylor,et al.  Combining computerized home-based treatments for generalized anxiety disorder: an attention modification program and cognitive behavioral therapy. , 2012, Behavior therapy.

[25]  K. Mogg,et al.  Direction of threat attention bias predicts treatment outcome in anxious children receiving cognitive-behavioural therapy. , 2012, Behaviour research and therapy.

[26]  Y. Bar-Haim,et al.  Variations in the Promoter Region of the Serotonin Transporter Gene and Biased Attention for Emotional Information: A Meta-Analysis , 2012, Biological Psychiatry.

[27]  Greg J Siegle,et al.  Neurobiological correlates of cognitions in fear and anxiety: A cognitive–neurobiological information-processing model , 2012, Cognition & emotion.

[28]  Konstantina Zougkou,et al.  The Serotonin Transporter Gene Alters Sensitivity to Attention Bias Modification: Evidence for a Plasticity Gene , 2011, Biological Psychiatry.

[29]  A. M. Ruscio,et al.  A meta-analysis of the effect of cognitive bias modification on anxiety and depression. , 2011, Psychological bulletin.

[30]  D. Collier,et al.  Therapygenetics: The 5HTTLPR and response to psychological therapy , 2011, Molecular Psychiatry.

[31]  A. Blokland,et al.  Acetylcholine and attention , 2011, Behavioural Brain Research.

[32]  K. Felmingham,et al.  Eye tracking and physiological reactivity to threatening stimuli in posttraumatic stress disorder. , 2011, Journal of anxiety disorders.

[33]  Bruno Verschuere,et al.  Effects of attention training on self-reported, implicit, physiological and behavioural measures of spider fear. , 2011, Journal of behavior therapy and experimental psychiatry.

[34]  P. Anderson,et al.  Vigilant and avoidant attention biases as predictors of response to cognitive behavioral therapy for social phobia , 2011, Depression and anxiety.

[35]  Daniel S Pine,et al.  Attention Biases to Threat Link Behavioral Inhibition to Social Withdrawal over Time in Very Young Children , 2011, Journal of abnormal child psychology.

[36]  M. Otto,et al.  A meta‐analysis of the magnitude of biased attention in depression , 2010, Depression and anxiety.

[37]  Monique Ernst,et al.  Attention Bias Modification Treatment: A Meta-Analysis Toward the Establishment of Novel Treatment for Anxiety , 2010, Biological Psychiatry.

[38]  Pradeep J Nathan,et al.  Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder , 2010, Neuropsychopharmacology.

[39]  Thomas Armstrong,et al.  Orienting and maintenance of gaze in contamination fear: Biases for disgust and fear cues. , 2010, Behaviour research and therapy.

[40]  N. Fox,et al.  Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces , 2010, Biological Psychology.

[41]  E. Koster,et al.  Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review. , 2010, Clinical psychology review.

[42]  Konstantina Zougkou,et al.  Preconscious Processing Biases Predict Emotional Reactivity to Stress , 2010, Biological Psychiatry.

[43]  F. Verhulst,et al.  CBT for childhood anxiety disorders: differential changes in selective attention between treatment responders and non-responders. , 2010, Journal of child psychology and psychiatry, and allied disciplines.

[44]  Juan Lupiáñez,et al.  Attention and Anxiety , 2010, Psychological science.

[45]  Justine M. Kent,et al.  Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze , 2009, Psychiatry Research: Neuroimaging.

[46]  A. Guastella,et al.  A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder , 2009, Psychoneuroendocrinology.

[47]  Paul Pauli,et al.  Fear of negative evaluation and the hypervigilance-avoidance hypothesis: an eye-tracking study , 2009, Journal of Neural Transmission.

[48]  A. Schwartzman,et al.  Selective attention and avoidance on a pictorial cueing task during stress in clinically anxious and depressed participants. , 2009, Behaviour research and therapy.

[49]  F. Verhulst,et al.  Threat-related selective attention predicts treatment success in childhood anxiety disorders. , 2009, Journal of the American Academy of Child and Adolescent Psychiatry.

[50]  J. Buckner,et al.  Attention training for generalized social anxiety disorder. , 2009, Journal of abnormal psychology.

[51]  A. Radomsky,et al.  Anxiety-control strategies: is there room for neutralization in successful exposure treatment? , 2008, Clinical psychology review.

[52]  Charles T. Taylor,et al.  The effect of a single-session attention modification program on response to a public-speaking challenge in socially anxious individuals. , 2008, Journal of abnormal psychology.

[53]  Andrew Hollingworth,et al.  Theories and measurement of visual attentional processing in anxiety , 2008 .

[54]  Paul Pauli,et al.  When spiders appear suddenly: spider-phobic patients are distracted by task-irrelevant spiders. , 2008, Behaviour research and therapy.

[55]  S. Hofmann Cognitive processes during fear acquisition and extinction in animals and humans: implications for exposure therapy of anxiety disorders. , 2008, Clinical psychology review.

[56]  Philip B. Mitchell,et al.  Oxytocin Increases Gaze to the Eye Region of Human Faces , 2008, Biological Psychiatry.

[57]  F. Schmidt Meta-Analysis , 2008 .

[58]  S. Mobini,et al.  Clinical implications of attentional bias in anxiety disorders: An integrative literature review. , 2007, Psychotherapy.

[59]  J. Abramowitz,et al.  Body vigilance in nonclinical and anxiety disorder samples: structure, correlates, and prediction of health concerns. , 2007, Behavior therapy.

[60]  M. Eysenck,et al.  Anxiety and cognitive performance: attentional control theory. , 2007, Emotion.

[61]  Roz Shafran,et al.  Attentional bias in eating disorders , 2007, The International journal of eating disorders.

[62]  Bruno Verschuere,et al.  Components of attentional bias to threat in high trait anxiety: Facilitated engagement, impaired disengagement, and attentional avoidance. , 2006, Behaviour research and therapy.

[63]  P. Kendall,et al.  Threat-Related Attentional Bias in Anxious Youth: A Review , 2006, Clinical child and family psychology review.

[64]  Bram Vervliet,et al.  Generalization gradients for acquisition and extinction in human contingency learning. , 2006, Experimental psychology.

[65]  J. Förster,et al.  Enactment of approach and avoidance behavior influences the scope of perceptual and conceptual attention , 2006 .

[66]  Bram Vervliet,et al.  Return of fear in a human differential conditioning paradigm caused by a stimulus change after extinction. , 2005, Behaviour research and therapy.

[67]  Pedro Avero,et al.  Time course of attentional bias to emotional scenes in anxiety: Gaze direction and duration , 2005, Cognition & emotion.

[68]  M. Bouton Context and behavioral processes in extinction. , 2004, Learning & memory.

[69]  D. Hermans,et al.  Reinstatement of extinguished conditioned responses and negative stimulus valence as a pathway to return of fear in humans. , 2004, Learning & memory.

[70]  B. Vervliet,et al.  Generalization of extinguished skin conductance responding in human fear conditioning. , 2004, Learning & memory.

[71]  T. Brown,et al.  The effects of acceptance versus suppression of emotion on subjective and psychophysiological response to carbon dioxide challenge in patients with panic disorder , 2004 .

[72]  A. Page,et al.  Attention to phobic stimuli during exposure: the effect of distraction on anxiety reduction, self-efficacy and perceived control. , 2004, Behaviour research and therapy.

[73]  Jane M Spurr,et al.  Self-focused attention in social phobia and social anxiety. , 2002, Clinical psychology review.

[74]  E. Fox,et al.  Attentional bias for threat: Evidence for delayed disengagement from emotional faces , 2002, Cognition & emotion.

[75]  G. Crombez,et al.  Expectancy-learning and evaluative learning in human classical conditioning: affective priming as an indirect and unobtrusive measure of conditioned stimulus valence. , 2002, Behaviour research and therapy.

[76]  M. Antony,et al.  Effect of distraction and coping style on in vivo exposure for specific phobia of spiders. , 2001, Behaviour research and therapy.

[77]  Lars-Göran Öst,et al.  Attentional Bias, Self-consciousness and Perfectionism in Social Phobia Before and After Cognitive-Behaviour Therapy , 2001 .

[78]  M. Craske,et al.  Effects of varied-stimulus exposure training on fear reduction and return of fear. , 1998, Behaviour research and therapy.

[79]  T. Dalgleish,et al.  The emotional Stroop task and psychopathology. , 1996, Psychological bulletin.

[80]  H. Merckelbach,et al.  Exposure therapy outcome in spider phobics: effects of monitoring and blunting coping styles. , 1995, Behaviour research and therapy.

[81]  H. Merckelbach,et al.  Monitoring Coping Style and Exposure Outcome in Spider Phobics , 1993, Behavioural and Cognitive Psychotherapy.

[82]  P. Ekman Facial expression and emotion. , 1993, The American psychologist.

[83]  J. Mattia,et al.  The revised Stroop color-naming task in social phobics. , 1993, Behaviour research and therapy.

[84]  D. Navon Forest before trees: The precedence of global features in visual perception , 1977, Cognitive Psychology.

[85]  A. Waters,et al.  Direction of attention bias to threat relates to differences in fear acquisition and extinction in anxious children. , 2015, Behaviour research and therapy.

[86]  D. Pine,et al.  Attention bias modification treatment augmenting effects on cognitive behavioral therapy in children with anxiety: randomized controlled trial. , 2014, Journal of the American Academy of Child and Adolescent Psychiatry.

[87]  G. Quirk,et al.  Fear extinction as a model for translational neuroscience: ten years of progress. , 2012, Annual review of psychology.

[88]  Josh M Cisler,et al.  Components of attentional biases in contamination fear: evidence for difficulty in disengagement. , 2010, Behaviour research and therapy.

[89]  A. Flykt,et al.  Fear, but not fear-relevance, modulates reaction times in visual search with animal distractors. , 2009, Journal of anxiety disorders.

[90]  Stephen D. Benning,et al.  ORIENTING AND MAINTENANCE OF GAZE IN CONTAMINATION-BASED OCD: BIASES FOR DISGUST AND FEAR CUES , 2009 .

[91]  M. Craske,et al.  Optimizing inhibitory learning during exposure therapy. , 2008, Behaviour research and therapy.

[92]  A. Page,et al.  Effects of internal and external distraction and focus during exposure to blood-injury-injection stimuli. , 2008, Journal of anxiety disorders.

[93]  Y. Bar-Haim,et al.  Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. , 2007, Psychological bulletin.

[94]  O. Lipp,et al.  When danger lurks in the background: attentional capture by animal fear-relevant distractors is specific and selectively enhanced by animal fear. , 2007, Emotion.

[95]  E. Foa,et al.  Emotional Processing Theory: An Update. , 2006 .

[96]  M. Craske,et al.  Exposure Therapy and Extinction: Clinical Studies. , 2006 .

[97]  A. Reinecke,et al.  Speeded detection and increased distraction in fear of spiders: evidence from eye movements. , 2005, Journal of abnormal psychology.

[98]  L. Hartley,et al.  Scopolamine and the control of attention in humans , 2004, Psychopharmacology.

[99]  E. Blanchard,et al.  Effect of psychological treatment on cognitive bias in motor vehicle accident-related Posttraumatic Stress Disorder. , 2004, Journal of anxiety disorders.

[100]  June Rathbone,et al.  The ‘Emotional’ Stroop Task , 2001 .

[101]  P. D. de Jong,et al.  Preconscious processing bias in specific phobia. , 1997, Behaviour research and therapy.

[102]  A. Wells A cognitive model of social phobia , 1995 .

[103]  A Arntz,et al.  Attentional bias and spider phobia: conceptual and clinical issues. , 1993, Behaviour research and therapy.

[104]  Harald Merckelbach,et al.  Is exposure therapy outcome affected by a monitoring coping style , 1993 .

[105]  David H. Barlow,et al.  Attention versus distraction during in vivo exposure: Snake and spider phobias , 1991 .

[106]  Suzanne M. Miller,et al.  The effect of information and coping style on the reduction of phobic anxiety during exposure , 1989 .

[107]  M. Kozak,et al.  Emotional processing of fear: exposure to corrective information. , 1986, Psychological bulletin.

[108]  T. Borkovec,et al.  Consequences of Increasing the Functional Impact of Internal Emotional Stimuli , 1980 .

[109]  J. Eccles The emotional brain. , 1980, Bulletin et memoires de l'Academie royale de medecine de Belgique.

[110]  J. Polivy,et al.  Assessment and Modification of Emotional Behavior , 1980 .