A four-electrode low frequency impedance spectroscopy measurement system using the AD5933 measurement chip

This paper presents the design of a four electrode impedance measurement circuit dedicated to bioimpedance embedded applications. It extends the use of the AD5933 measurement chip to allow it to operate in a four electrode configuration in order to limit the effects of the parasitic impedances between the medium under test and the electrodes. The circuit has shown a good measurement accuracy on various test circuits. In association with a four microband electrode system it has been successfully used to characterize small physiological samples (50 μl) with conductivities ranging from 0.14 to 1.2 S m(-1). It can be used as an alternative bioimpedance measurement approach for embedded applications operating in the four electrode configuration.

[1]  Fernando Seoane,et al.  An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications , 2008, Physiological measurement.

[2]  Chung Bang Yun,et al.  Wireless Structural Health Monitoring Using an Active Sensing Node , 2006 .

[3]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[4]  Viera Stopjakova,et al.  WIRELESS MEASUREMENT SYSTEM FOR NON-INVASIVE BIOMEDICAL MONITORING OF PSYCHO-PHYSIOLOGICAL PROCESSES , 2009 .

[5]  Fernando Seoane,et al.  AD5933-based Spectrometer for Electrical Bioimpedance Applications , 2010 .

[6]  A. Schwinde,et al.  On-line control of cellular adhesion with impedance measurements using interdigitated electrode structures , 1998, Medical and Biological Engineering and Computing.

[7]  Fernando Seoane,et al.  AD5933-based electrical bioimpedance spectrometer. Towards textile-enabled applications , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[8]  Marc Bodenstein,et al.  Principles of electrical impedance tomography and its clinical application , 2009, Critical care medicine.

[9]  J Jossinet,et al.  Tissue impedance: a historical overview. , 1995, Physiological measurement.

[10]  J P Morucci,et al.  Bioelectrical impedance techniques in medicine. Part I: Bioimpedance measurement. Second section: impedance spectrometry. , 1996, Critical reviews in biomedical engineering.

[11]  Richard D. Rabbitt,et al.  Electric impedance spectroscopy using microchannels with integrated metal electrodes , 1999 .

[12]  M. Nadi.  Dielectric Characterization of Biological Tissues: Constraints Related to Ex Vivo Measurements , 2008 .

[13]  G. R. Facer,et al.  Capacitance cytometry: measuring biological cells one by one. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Steffen Leonhardt,et al.  On the Road to a Textile Integrated Bioimpedance Early Warning System for Lung Edema , 2010, 2010 International Conference on Body Sensor Networks.

[15]  Daniel J. Inman,et al.  Wireless structural health monitoring for critical members of civil infrastructures using piezoelectric active sensors , 2008, SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring.

[16]  J. Wegener,et al.  Electric cell-substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces. , 2000, Experimental cell research.

[17]  E. McAdams,et al.  The linear and non-linear electrical properties of the electrode-electrolyte interface , 1995 .

[18]  R. Pethig.  Dielectric Properties of Biological Materials: Biophysical and Medical Applications , 1984, IEEE Transactions on Electrical Insulation.

[19]  S. Gawad,et al.  Impedance spectroscopy flow cytometry: On‐chip label‐free cell differentiation , 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[20]  Kenneth R. Foster,et al.  Dielectric Properties of Tissues , 2008 .

[21]  Joachim Wegener,et al.  Bioelectrical impedance assay to monitor changes in cell shape during apoptosis. , 2004, Biosensors & bioelectronics.