Midkine exacerbates pressure overload-induced cardiac remodeling.

[1]  K. Nakao,et al.  Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure , 2013, Cardiovascular research.

[2]  J. Taunton,et al.  p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction , 2012, Circulation research.

[3]  L. Tavazzi,et al.  Clinical outcome of renal tubular damage in chronic heart failure. , 2011, European heart journal.

[4]  I. Kubota,et al.  8‐Hydroxy‐2′‐deoxyguanosine is a prognostic mediator for cardiac event , 2011, European journal of clinical investigation.

[5]  J. Molkentin,et al.  Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. , 2010, Circulation.

[6]  C. Molina,et al.  Novel role of C terminus of Hsc70‐interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5‐mediated degradation of inducible cAMP early repressor , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  I. Kubota,et al.  Serum midkine as a predictor of cardiac events in patients with chronic heart failure. , 2010, Journal of cardiac failure.

[8]  T. Opthof,et al.  Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction. , 2010, Cardiovascular research.

[9]  J. Molkentin,et al.  Extracellular signal‐regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy , 2010, Annals of the New York Academy of Sciences.

[10]  I. Kodama,et al.  Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction. , 2009, American journal of physiology. Heart and circulatory physiology.

[11]  C. Molina,et al.  Effects of MEK5/ERK5 Association on Small Ubiquitin-Related Modification of ERK5: Implications for Diabetic Ventricular Dysfunction After Myocardial Infarction , 2008, Circulation research.

[12]  Y. Yuzawa,et al.  Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy , 2007, Laboratory Investigation.

[13]  S. Russell,et al.  Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study. , 2007, Journal of the American Society of Nephrology : JASN.

[14]  K. Kamiya,et al.  Midkine Plays a Protective Role Against Cardiac Ischemia/Reperfusion Injury Through a Reduction of Apoptotic Reaction , 2006, Circulation.

[15]  T. Muramatsu,et al.  Neuroglycan C Is a Novel Midkine Receptor Involved in Process Elongation of Oligodendroglial Precursor-like Cells* , 2006, Journal of Biological Chemistry.

[16]  I. Kubota,et al.  Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury. , 2006, Biochemical and biophysical research communications.

[17]  I. Kubota,et al.  Cardiac-Specific Overexpression of Diacylglycerol Kinase &zgr; Prevents Gq Protein-Coupled Receptor Agonist-Induced Cardiac Hypertrophy in Transgenic Mice , 2005, Circulation.

[18]  J. Ornato,et al.  ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult—Summary Article , 2005 .

[19]  G. Dorn,et al.  Protein kinase cascades in the regulation of cardiac hypertrophy. , 2005, The Journal of clinical investigation.

[20]  I. Kubota,et al.  Modulation of Doxorubicin-Induced Cardiac Dysfunction in Toll-Like Receptor-2–Knockout Mice , 2004, Circulation.

[21]  P. Reynolds,et al.  Midkine Is Regulated by Hypoxia and Causes Pulmonary Vascular Remodeling* , 2004, Journal of Biological Chemistry.

[22]  T. Muramatsu,et al.  Midkine and pleiotrophin in neural development and cancer. , 2004, Cancer letters.

[23]  C. O'connor,et al.  Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations. , 2003, The American journal of cardiology.

[24]  Osamu Takeuchi,et al.  Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction , 2002, Circulation.

[25]  T. Muramatsu.  Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. , 2002, Journal of biochemistry.

[26]  N. Hotta,et al.  Midkine Is Involved in Neutrophil Infiltration into the Tubulointerstitium in Ischemic Renal Injury1 , 2001, The Journal of Immunology.

[27]  Y. Yuzawa,et al.  Neointima formation in a restenosis model is suppressed in midkine-deficient mice. , 2000, The Journal of clinical investigation.

[28]  Mitsutoshi Nakamura,et al.  Immunohistochemical Analysis of Midkine Expression in Human Prostate Carcinoma , 1999, Oncology.

[29]  K. Mishima,et al.  Increased expression of midkine during the progression of human astrocytomas , 1997, Neuroscience Letters.

[30]  J. Miller,et al.  Early predictors of 15-year end-stage renal disease in hypertensive patients. , 1995, Hypertension.

[31]  T. Muramatsu,et al.  Purification of recombinant midkine and examination of its biological activities: functional comparison of new heparin binding factors. , 1991, Biochemical and biophysical research communications.

[32]  K. Weber,et al.  Pathological Hypertrophy and Cardiac Interstitium: Fibrosis and Renin‐Angiotensin‐Aldosterone System , 1991, Circulation.

[33]  I. Kubota,et al.  Renal tubulointerstitial damage is associated with short-term cardiovascular events in patients with myocardial infarction. , 2013, Circulation journal : official journal of the Japanese Circulation Society.

[34]  保浦 晃徳.  The growth factor midkine regulates the renin-angiotensin system in mice , 2009 .

[35]  I. Kubota,et al.  Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy. , 2007, Circulation journal : official journal of the Japanese Circulation Society.

[36]  高田徹.  Midkine,a Retinoic Acid-inducible Heparin-binding Cytokine in Inflammatory Responses: Chemotactic Activity to Neutrophils and Association with Inflammatory Synovitis(炎症反応における、レチノイン酸誘導性ヘパリン親和性サイトカイン、ミッドカイン: 好中球遊走能とおよび炎症性滑膜炎との関連について) , 1997 .