The Multicenter Osteoarthritis Study: Opportunities for Rehabilitation Research

The Multicenter Osteoarthritis Study (MOST) is a longitudinal observational study of the effects of biomechanical, bone and joint structural, and nutritional factors on the incidence and progression of knee symptoms and radiographic and symptomatic knee osteoarthritis (OA). It is the first large-scale epidemiologic study to focus on symptomatic knee OA in a community-based sample of adultswith or at high risk for knee OA, based on thepresence of knee symptoms, history of knee injury or surgery or being overweight. Beginning in 2003, 3026 individuals (60.1% women) age 50-79 years were enrolled. Examinations at baseline, and 15, 30, 60, 72 and 84 months later included assessment of risk factors, disease characteristics, body functions and structure, and measures of physical activity and participation. The wealth of data from this longitudinal cohort of community-dwelling older adults affords valuable opportunities for rehabilitation researchers.

[1]  C. Tudor-Locke,et al.  Walking to meet physical activity guidelines in knee osteoarthritis: is 10,000 steps enough? , 2013, Archives of physical medicine and rehabilitation.

[2]  M. Nevitt,et al.  Effect of quadriceps strength and proprioception on risk for knee osteoarthritis. , 2010, Medicine and science in sports and exercise.

[3]  Marcus J Fuhrer,et al.  Rehabilitation medicine summit: building research capacity Executive Summary , 2006, Journal of NeuroEngineering and Rehabilitation.

[4]  J. Kellgren,et al.  Radiological Assessment of Osteo-Arthrosis , 1957, Annals of the rheumatic diseases.

[5]  L. Fredman,et al.  When it hurts, a positive attitude may help: association of positive affect with daily walking in knee osteoarthritis. Results from a multicenter longitudinal cohort study , 2012, Arthritis care & research.

[6]  Gheorghe Luta,et al.  Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. , 2007, The Journal of rheumatology.

[7]  Hai Fang,et al.  Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. , 2009, Arthritis and rheumatism.

[8]  M. Nevitt,et al.  The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis. , 2009, Arthritis and rheumatism.

[9]  M. Nevitt,et al.  The longitudinal relationship between thigh muscle mass and the development of knee osteoarthritis. , 2012, Osteoarthritis and cartilage.

[10]  L. Sharma,et al.  Knee Extensor Strength Does Not Protect Against Incident Knee Symptoms at 30 Months in the Multicenter Knee Osteoarthritis (MOST) Cohort , 2009, PM & R : the journal of injury, function, and rehabilitation.

[11]  P. Heagerty,et al.  Study Protocol- Lumbar Epidural Steroid Injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults , 2012, BMC Musculoskeletal Disorders.

[12]  The relationship of vibratory perception to dynamic joint loading, radiographic severity, and pain in knee osteoarthritis. , 2012, Arthritis and rheumatism.

[13]  Alan M Jette,et al.  Community environmental factors are associated with disability in older adults with functional limitations: the MOST study. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[14]  M. Nevitt,et al.  Muscle mass is more strongly related to hip bone mineral density than is quadriceps strength or lower activity level in adults over age 50 year. , 2008, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[15]  L. Sharma,et al.  Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort. , 2010, Osteoarthritis and cartilage.

[16]  H. Genant,et al.  Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. , 2004, Osteoarthritis and cartilage.

[17]  M. Roizen.  Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort , 2010 .