Should T-wave alternans magnitude be corrected with T-wave amplitude in the ultra-short-term prediction of life-threatening cardiac arrhythmias?

We appreciate efforts by Dr Madias to develop T-wave alternans (TWA) index based on the theory that TWA magnitude is affected by T-wave amplitude and should, therefore, be corrected.1 He suggested that there may be limitations in correlating TWA magnitude data derived from the J-point to the end of the T-wave with the corresponding peak of the T-wave.2 We could not measure the area under the ECG curve from the J-point to …

[1]  J. Madias A proposal for a T-wave alternans index. , 2007, Journal of electrocardiology.

[2]  J. Madias Relationship between T-wave alternans magnitude and T-wave amplitude before onset of ventricular tachyarrhythmias during emergent reperfusion in acute coronary syndrome patients: a response , 2011 .

[3]  T. Aoyama,et al.  Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome. , 2011, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.