The Impact of Chronic Phthalate Exposure on Rodent Anxiety and Cognition

[1]  D. Yoo,et al.  Long-term exposure changes the environmentally relevant bis(2-ethylhexyl) phthalate to be a neuro-hazardous substance disrupting neural homeostasis in emotional and cognitive functions. , 2023, Environmental pollution.

[2]  M. Herting,et al.  Neurotoxicants, the Developing Brain, and Mental Health , 2022, Biological psychiatry global open science.

[3]  L. Chalifour,et al.  Acute exposure to phthalates during recovery from a myocardial infarction induces greater inflammasome activation in male C57bl/6N mice. , 2022, Toxicology and applied pharmacology.

[4]  S. Mhaouty-Kodja,et al.  Behavioral Effects of Exposure to Phthalates in Female Rodents: Evidence for Endocrine Disruption? , 2022, International journal of molecular sciences.

[5]  Hua Wang,et al.  Di (2-ethyl-hexyl) phthalate disrupts placental growth in a dual blocking mode. , 2021, Journal of hazardous materials.

[6]  H. Mohammadi,et al.  Mechanistic insight into toxicity of phthalates, the involved receptors, and the role of Nrf2, NF-κB, and PI3K/AKT signaling pathways , 2021, Environmental Science and Pollution Research.

[7]  P. Marvar,et al.  Internal state-dependent conditioned stimulus delivery using cardiovascular telemetry in mice , 2021, Physiology & Behavior.

[8]  J. Manson,et al.  Biomarkers of phthalates and inflammation: Findings from a subgroup of Women's Health Initiative participants. , 2021, International journal of hygiene and environmental health.

[9]  H. Patisaul,et al.  Neurotoxicity of Ortho-Phthalates: Recommendations for Critical Policy Reforms to Protect Brain Development in Children. , 2021, American journal of public health.

[10]  N. Posnack.  Plastics and cardiovascular disease , 2020, Nature Reviews Cardiology.

[11]  B. Coull,et al.  Association of Exposure to Endocrine-Disrupting Chemicals During Adolescence With Attention-Deficit/Hyperactivity Disorder–Related Behaviors , 2020, JAMA network open.

[12]  M. Ramadan,et al.  Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes , 2020, Birth defects research.

[13]  J. Flaws,et al.  Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice , 2019, Physiology & Behavior.

[14]  M. Kamijima,et al.  Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review , 2019, Environmental Health and Preventive Medicine.

[15]  Min Wang,et al.  The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts. , 2019, Neurotoxicology.

[16]  Jiansong Sheng,et al.  Plasticizer Interaction With the Heart , 2019, Circulation. Arrhythmia and electrophysiology.

[17]  A. Calafat,et al.  Endocrine disrupting chemical exposure and maladaptive behavior during adolescence. , 2019, Environmental research.

[18]  Han-Bin Huang,et al.  Prenatal and childhood exposure to phthalate diesters and neurobehavioral development in a 15-year follow-up birth cohort study. , 2019, Environmental research.

[19]  J. Merchant,et al.  Phthalate-associated hypertension in premature infants: a prospective mechanistic cohort study , 2019, Pediatric Nephrology.

[20]  A. Seligowski,et al.  Extinction of Fear Memory Attenuates Conditioned Cardiovascular Fear Reactivity , 2018, Front. Behav. Neurosci..

[21]  R. Tiwary,et al.  MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis. , 2018, Reproduction.

[22]  Lei Wang,et al.  Exposure to phthalates in patients with diabetes and its association with oxidative stress, adiponectin, and inflammatory cytokines. , 2017, Environment international.

[23]  Narine Muselimyan,et al.  Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity. , 2017, American journal of physiology. Heart and circulatory physiology.

[24]  G. Neigh,et al.  Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad , 2017, Frontiers in Neuroendocrinology.

[25]  A. Calafat,et al.  Co-exposure to non-persistent organic chemicals among American pre-school aged children: A pilot study. , 2017, International journal of hygiene and environmental health.

[26]  J. Braun,et al.  Early-life exposure to EDCs: role in childhood obesity and neurodevelopment , 2017, Nature Reviews Endocrinology.

[27]  R. Snyder,et al.  Direct and transgenerational effects of low doses of perinatal di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice , 2017, PloS one.

[28]  Kyongbum Lee,et al.  Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways , 2016, Environmental health perspectives.

[29]  S. Shyue,et al.  Maternal exposure to di-(2-ethylhexyl) phthalate exposure deregulates blood pressure, adiposity, cholesterol metabolism and social interaction in mouse offspring , 2016, Archives of Toxicology.

[30]  J. Herman,et al.  Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response. , 2016, Comprehensive Physiology.

[31]  M. Hill,et al.  Endocrine disruptors and other inhibitors of 11β-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition , 2016, The Journal of Steroid Biochemistry and Molecular Biology.

[32]  D. Dewey,et al.  Phthalate exposure and childrens neurodevelopment: A systematic review. , 2015, Environmental research.

[33]  Chao Liu,et al.  Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin , 2015, Scientific Reports.

[34]  T. J. Doyle,et al.  Transgenerational Effects of Di-(2-Ethylhexyl) Phthalate (DEHP) on Stress Hormones and Behavior. , 2015, Endocrinology.

[35]  D. Aronoff,et al.  Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells , 2015, Reproductive Biology and Endocrinology.

[36]  Xiaohong Xu,et al.  Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice. , 2015, Chemosphere.

[37]  S. Swan,et al.  First trimester phthalate exposure and anogenital distance in newborns. , 2015, Human reproduction.

[38]  A. Angrilli,et al.  Greater general startle reflex is associated with greater anxiety levels: a correlational study on 111 young women , 2015, Front. Behav. Neurosci..

[39]  Bung-Nyun Kim,et al.  Di-(2-Ethylhexyl) Phthalate Exposure Is Negatively Correlated with Trait Anxiety in Girls but not with Trait Anxiety in Boys or Anxiety-Like Behavior in Male Mice , 2015, Journal of child neurology.

[40]  P. Liao,et al.  Prenatal Exposure to Phthalate Esters and Behavioral Syndromes in Children at 8 Years of Age: Taiwan Maternal and Infant Cohort Study , 2014, Environmental health perspectives.

[41]  Dean-Chuan Wang,et al.  Exercise prevents the increased anxiety-like behavior in lactational di-(2-ethylhexyl) phthalate-exposed female rats in late adolescence by improving the regulation of hypothalamus-pituitary-adrenal axis , 2014, Hormones and Behavior.

[42]  J. Richburg,et al.  Age- and Species-Dependent Infiltration of Macrophages into the Testis of Rats and Mice Exposed to Mono-(2-Ethylhexyl) Phthalate (MEHP)1 , 2014, Biology of reproduction.

[43]  T. Woodruff,et al.  Temporal Trends in Phthalate Exposures: Findings from the National Health and Nutrition Examination Survey, 2001–2010 , 2014, Environmental health perspectives.

[44]  Michel Boulouard,et al.  Object recognition test in mice , 2013, Nature Protocols.

[45]  H. Nitta,et al.  Expression levels of neuroimmune biomarkers in hypothalamus of allergic mice after phthalate exposure , 2013, Journal of applied toxicology : JAT.

[46]  J. Seckl,et al.  11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. , 2013, Physiological reviews.

[47]  J. Holme,et al.  Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264.7 cells. , 2012, Toxicology letters.

[48]  N. Singewald,et al.  Enhanced Fear Expression in a Psychopathological Mouse Model of Trait Anxiety: Pharmacological Interventions , 2011, PLoS ONE.

[49]  U. Hass,et al.  Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats. , 2010, Reproductive toxicology.

[50]  D. Laskin,et al.  Inflammatory Effects of Phthalates in Neonatal Neutrophils , 2010, Pediatric Research.

[51]  Bung-Nyun Kim,et al.  Phthalates Exposure and Attention-Deficit/Hyperactivity Disorder in School-Age Children , 2009, Biological Psychiatry.

[52]  D. Hardy,et al.  Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11beta-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells. , 2009, Biochemical and biophysical research communications.

[53]  U. Bondesson,et al.  Effects of di-(2-ethylhexyl) phthalate and five of its metabolites on rat testis in vivo and in in vitro. , 2009, Acta pharmacologica et toxicologica.

[54]  W. Ray,et al.  Startle response in Generalized Anxiety Disorder , 2009, Depression and anxiety.

[55]  J. Angerer,et al.  Time- and Dose-Related Effects of Di-(2-ethylhexyl) Phthalate and Its Main Metabolites on the Function of the Rat Fetal Testis in Vitro , 2008, Environmental Health Perspectives.

[56]  R. Sapolsky,et al.  Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy , 2008, Proceedings of the National Academy of Sciences.

[57]  I. Chahoud,et al.  A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. , 2006, Toxicology.

[58]  A. Afshari,et al.  Emission of phthalates from PVC and other materials. , 2004, Indoor air.

[59]  A. Calafat,et al.  Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate. , 2004, Environmental health perspectives.

[60]  Dana B Barr,et al.  Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. , 2003, Environmental health perspectives.

[61]  T. Lovekamp-Swan,et al.  Mechanisms of phthalate ester toxicity in the female reproductive system. , 2002, Environmental health perspectives.

[62]  J. Klaunig,et al.  Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[63]  R. M. David,et al.  Reversibility of the Chronic Effects of Di(2-ethylhexyl)phthalate , 2001, Toxicologic pathology.

[64]  J. Moguilevsky,et al.  Effect of di(2-ethylhexyl) phthalate on the neuroendocrine regulation of reproduction in adult male rats and its relationship to anxiogenic behavior: Participation of GABAergic system , 2019, Human & experimental toxicology.

[65]  Stephen Maren,et al.  Stress and Fear Extinction , 2016, Neuropsychopharmacology.

[66]  B. Eskenazi,et al.  Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6-15 years. , 2014, Environmental research.

[67]  K. Iwabuchi,et al.  Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages , 2011, Inflammation Research.

[68]  JoVE Video Dataset , 2022 .