Production of inter-connective porous dental implants by computer-aided design and metal three-dimensional printing

Even though dental implants are considered reliable for replacing missing teeth, their use in medically compromised alveolar bone or under excessive occlusal force remains problematic. Here, we developed and manufactured novel inter-connective porous dental implants by selective laser melting technology. Finite element analysis was used to evaluate the stress distribution, micro-motion, and fatigue damage of implants under static and dynamic loading conditions. Osseointegration of the implant surface, ingrowth of bone tissue into pores, and binding strength at the implant–bone interface were evaluated in vivo. Selective laser melting 3D printing technology was efficient for printing the pre-designed irregular implants with an inter-connective porous structure. Dental implants with porous designs can theoretically withstand long-term physiological function and had increased implant–bone contact areas and binding strength; thus, this approach holds immense potential for improving the clinical performance of implants.

[1]  Jia You,et al.  Selective laser melting of titanium alloy enables osseointegration of porous multi-rooted implants in a rabbit model , 2016, BioMedical Engineering OnLine.

[2]  M. C. H. Meulen,et al.  Whole Bone Mechanics and Bone Quality , 2011, Clinical orthopaedics and related research.

[3]  Timothy Douglas,et al.  Rapid prototyping: porous titanium alloy scaffolds produced by selective laser melting for bone tissue engineering. , 2009, Tissue engineering. Part C, Methods.

[4]  Jianglin Ouyang,et al.  Osseointegration of three-dimensional designed titanium implants manufactured by selective laser melting , 2016, Biofabrication.

[5]  L. Song,et al.  Selection of optimal dental implant diameter and length in type IV bone: a three-dimensional finite element analysis. , 2009, International journal of oral and maxillofacial surgery.

[6]  Jianyu Chen,et al.  Design and manufacture of customized dental implants by using reverse engineering and selective laser melting technology. , 2014, The Journal of prosthetic dentistry.

[7]  Mariana Calin,et al.  Manufacture by selective laser melting and mechanical behavior of commercially pure titanium , 2014 .

[8]  A. Shimano,et al.  Analyzing the Influence of a New Dental Implant Design on Primary Stability. , 2016, Clinical implant dentistry and related research.

[9]  M. A. Pérez,et al.  Life prediction of different commercial dental implants as influence by uncertainties in their fatigue material properties and loading conditions , 2012, Comput. Methods Programs Biomed..

[10]  J. N. Waddell,et al.  Additive Technology: Update on Current Materials and Applications in Dentistry. , 2017, Journal of prosthodontics : official journal of the American College of Prosthodontists.

[11]  Baolin Liu,et al.  Optimization of the implant diameter and length in type B/2 bone for improved biomechanical properties: A three-dimensional finite element analysis , 2009, Adv. Eng. Softw..

[12]  Y C Loo,et al.  Application of finite element method in dental implant research , 2009 .

[13]  S D Cook,et al.  In vivo performance of a modified CSTi dental implant coating. , 1998, The International journal of oral & maxillofacial implants.

[14]  H. Costa,et al.  Effect of Macrogeometry on the Surface Topography of Dental Implants. , 2015, The International journal of oral & maxillofacial implants.

[15]  P Missika,et al.  Optimal implant stabilization in low density bone. , 2001, Clinical oral implants research.

[16]  Fehmi Erzincanlı,et al.  Static, dynamic and fatigue behaviors of dental implant using finite element method , 2006, Adv. Eng. Softw..

[17]  Yoshiki Oshida,et al.  Dental Implant Systems , 2010, International journal of molecular sciences.

[18]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[19]  A Piattelli,et al.  Direct laser metal sintering as a new approach to fabrication of an isoelastic functionally graded material for manufacture of porous titanium dental implants. , 2008, Dental materials : official publication of the Academy of Dental Materials.

[20]  Yew-Chaye Loo,et al.  Step-wise analysis of the dental implant insertion process using the finite element technique. , 2008, Clinical oral implants research.

[21]  Wai Yee Yeong,et al.  Laser and electron‐beam powder‐bed additive manufacturing of metallic implants: A review on processes, materials and designs , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[22]  F. Kloss,et al.  Impact of Dental Implant Surface Modifications on Osseointegration , 2016, BioMed research international.

[23]  Abdullah Barazanchi Bds,et al.  Additive Technology: Update on Current Materials and Applications in Dentistry , 2016 .

[24]  M. Figliuzzi,et al.  A novel root analogue dental implant using CT scan and CAD/CAM: selective laser melting technology. , 2012, International journal of oral and maxillofacial surgery.

[25]  R. Jung,et al.  Clinical Outcomes of Zirconia Dental Implants: A Systematic Review , 2017, Journal of dental research.

[26]  J. Lee,et al.  Bone Ingrowth and Initial Stability of Titanium and Porous Tantalum Dental Implants: A Pilot Canine Study , 2013, Implant dentistry.

[27]  Francesco Guido Mangano,et al.  Custom-made, root-analogue direct laser metal forming implant: a case report , 2012, Lasers in Medical Science.

[28]  Baohong Zhao,et al.  Assessment of implant cumulative survival rates in sites with different bone density and related prognostic factors: an 8-year retrospective study of 2,684 implants. , 2015, The International journal of oral & maxillofacial implants.

[29]  X. Qu,et al.  Smoking, Radiotherapy, Diabetes and Osteoporosis as Risk Factors for Dental Implant Failure: A Meta-Analysis , 2013, PloS one.

[30]  H Van Oosterwyck,et al.  The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds. , 2012, Acta biomaterialia.

[31]  Cho-Pei Jiang,et al.  Application of uniform design to improve dental implant system. , 2015, Bio-medical materials and engineering.

[32]  Yan Hu,et al.  Osteogenesis of 3D printed porous Ti6Al4V implants with different pore sizes. , 2018, Journal of the mechanical behavior of biomedical materials.