Droplet Breakup in Expansion-contraction Microchannels

We investigate the influences of expansion-contraction microchannels on droplet breakup in capillary microfluidic devices. With variations in channel dimension, local shear stresses at the injection nozzle and focusing orifice vary, significantly impacting flow behavior including droplet breakup locations and breakup modes. We observe transition of droplet breakup location from focusing orifice to injection nozzle, and three distinct types of recently-reported tip-multi-breaking modes. By balancing local shear stresses and interfacial tension effects, we determine the critical condition for breakup location transition, and characterize the tip-multi-breaking mode quantitatively. In addition, we identify the mechanism responsible for the periodic oscillation of inner fluid tip in tip-multi-breaking mode. Our results offer fundamental understanding of two-phase flow behaviors in expansion-contraction microstructures, and would benefit droplet generation, manipulation and design of microfluidic devices.

[1]  D. Weitz,et al.  Breakup of double emulsions in constrictions , 2011 .

[2]  Jiating He,et al.  Thermodynamics versus kinetics in nanosynthesis. , 2015, Angewandte Chemie.

[3]  Wingki Lee,et al.  Role of geometry and fluid properties in droplet and thread formation processes in planar flow focusing , 2009 .

[4]  Shinji Katsura,et al.  Single-molecule PCR using water-in-oil emulsion. , 2003, Journal of biotechnology.

[5]  Helen Song,et al.  Reactions in Droplets in Microfluidic Channels , 2007 .

[6]  S. Tomotika On the Instability of a Cylindrical Thread of a Viscous Liquid Surrounded by Another Viscous Fluid , 1935 .

[7]  Ellen K. Longmire,et al.  Drop motion through a confining orifice , 2014, Journal of Fluid Mechanics.

[8]  Randall M. Erb,et al.  Predicting sizes of droplets made by microfluidic flow-induced dripping , 2011 .

[9]  Seung-Man Yang,et al.  Microfluidic multicolor encoding of microspheres with nanoscopic surface complexity for multiplex immunoassays. , 2011, Angewandte Chemie.

[10]  V. Patravale,et al.  Novel cosmetic delivery systems: an application update , 2008, International journal of cosmetic science.

[11]  Seung-Man Yang,et al.  Designed pneumatic valve actuators for controlled droplet breakup and generation. , 2010, Lab on a chip.

[12]  H. Shum,et al.  Capillary micromechanics for core-shell particles. , 2014, Soft matter.

[13]  S. Quake,et al.  Dynamic pattern formation in a vesicle-generating microfluidic device. , 2001, Physical review letters.

[14]  Liqiu Wang,et al.  Nanoliter-droplet breakup in confined T-shaped junctions , 2011 .

[15]  Jong-Min Lim,et al.  Controlled generation of submicron emulsion droplets via highly stable tip-streaming mode in microfluidic devices. , 2012, Lab on a chip.

[16]  Stephan Herminghaus,et al.  In situ formation, manipulation, and imaging of droplet-encapsulated fibrin networks. , 2009, Lab on a chip.

[17]  Hon Fai Chan,et al.  Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment , 2013, Scientific Reports.

[18]  S. Herminghaus,et al.  Droplet based microfluidics , 2012, Reports on progress in physics. Physical Society.

[19]  N. Anton,et al.  Microfluidic conceived pH sensitive core-shell particles for dual drug delivery. , 2015, International journal of pharmaceutics.

[20]  S. Anna,et al.  Microfluidic methods for generating continuous droplet streams , 2007 .

[21]  Xiaoxia Wang,et al.  Image Decoding of Photonic Crystal Beads Array in the Microfluidic Chip for Multiplex Assays , 2014, Scientific reports.

[22]  Andrew G. Glen,et al.  APPL , 2001 .

[23]  Wei Wang,et al.  Functional polymeric microparticles engineered from controllable microfluidic emulsions. , 2014, Accounts of chemical research.

[24]  Y. Hemar,et al.  Nano‐ and Micro‐Structured Assemblies for Encapsulation of Food Ingredients , 2009 .

[25]  Z. Kang,et al.  Tip-multi-breaking in Capillary Microfluidic Devices , 2015, Scientific Reports.

[26]  H. Shum,et al.  Engineering polymeric composite particles by emulsion-templating: Thermodynamics versus Kinetics , 2013 .

[27]  David A Weitz,et al.  Polymer microcapsules with programmable active release. , 2013, Journal of the American Chemical Society.

[28]  Vittorio Cristini,et al.  Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting. , 2004, Lab on a chip.

[29]  Khashayar Khoshmanesh,et al.  A multi-functional bubble-based microfluidic system , 2015, Scientific Reports.

[30]  H. Stone,et al.  Dripping and jetting in microfluidic multiphase flows applied to particle and fibre synthesis , 2013, Journal of physics D: Applied physics.

[31]  E. Villermaux,et al.  Physics of liquid jets , 2008 .

[32]  A. deMello Control and detection of chemical reactions in microfluidic systems , 2006, Nature.

[33]  Liqiu Wang,et al.  Microfluidics: Fabrication, Droplets, Bubbles and Nanofluids Synthesis , 2011 .

[34]  Ju Hyeon Kim,et al.  Droplet microfluidics for producing functional microparticles. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[35]  Armand Ajdari,et al.  Stability of a jet in confined pressure-driven biphasic flows at low reynolds numbers. , 2007, Physical review letters.

[36]  G. Batchelor,et al.  An Introduction to Fluid Dynamics , 1968 .

[37]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[38]  Charles N Baroud,et al.  Dynamics of microfluidic droplets. , 2010, Lab on a chip.

[39]  Geoffrey Ingram Taylor,et al.  The formation of emulsions in definable fields of flow , 1934 .

[40]  Chun-Xia Zhao,et al.  Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery. , 2013, Advanced drug delivery reviews.

[41]  Hans C. Mayer,et al.  Microscale tipstreaming in a microfluidic flow focusing device , 2006 .

[42]  A. Manz,et al.  Lab-on-a-chip: microfluidics in drug discovery , 2006, Nature Reviews Drug Discovery.

[43]  Y. Qiu,et al.  Microfluidic-based fabrication, characterization and magnetic functionalization of microparticles with novel internal anisotropic structure , 2015, Scientific Reports.

[44]  D. Weitz,et al.  Geometrically mediated breakup of drops in microfluidic devices. , 2003, Physical review letters.

[45]  H. Stone,et al.  Transition from squeezing to dripping in a microfluidic T-shaped junction , 2008, Journal of Fluid Mechanics.

[46]  Howard A Stone,et al.  An "off-the-shelf" capillary microfluidic device that enables tuning of the droplet breakup regime at constant flow rates. , 2013, Lab on a chip.

[47]  Carsten Haber,et al.  Microfluidics in commercial applications; an industry perspective. , 2006, Lab on a chip.

[48]  P. Umbanhowar,et al.  Monodisperse Emulsion Generation via Drop Break Off in a Coflowing Stream , 2000 .