Regenerative Therapies in Neonatology: Clinical Perspectives

Abstract Regenerative therapy based on stem cells is applied as standard therapy in pediatric oncology. Furthermore, they are frequently used to treat immunodeficiency disorders of infants. For severe neonatal diseases, e. g. hypoxic-ischemic encephalopathy in term neonates or bronchopulmonary dysplasia in preterm infants, animal models have been established. According to some first preclinical results stem cell administration appears as a promising tool to improve the clinical outcome in high-risk infants. Provided the benefit of regenerative therapies can further be evaluated in appropriate preclinical neonate models, carefully controlled clinical trials to assess the significance of regenerative therapies, such as autologous stem cell administration, are indicated.

[1]  S. Zhang,et al.  Role of bone marrow‐derived mesenchymal stem cells in the prevention of hyperoxia‐induced lung injury in newborn mice , 2012, Cell biology international.

[2]  P. Mourani,et al.  Cord blood angiogenic progenitor cells are decreased in bronchopulmonary dysplasia , 2012, European Respiratory Journal.

[3]  F. Abdul Wahid,et al.  Effects of preeclampsia on the yield of hematopoietic stem cells obtained from umbilical cord blood at delivery , 2012, The journal of obstetrics and gynaecology research.

[4]  S. Chouaib,et al.  Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape , 2012, Front. Immun..

[5]  Bernd Giebel,et al.  Exosomes: small vesicles participating in intercellular communication. , 2012, The international journal of biochemistry & cell biology.

[6]  M. Benesch,et al.  Stem Cell Transplantation in 6 Children with Parvovirus B19- Induced Severe Aplastic Anaemia or Myelodysplastic Syndrome , 2011, Klinische Pädiatrie.

[7]  J. Carlin,et al.  Rates of cerebral palsy in Victoria, Australia, 1970 to 2004: has there been a change? , 2011, Developmental medicine and child neurology.

[8]  Bernd Giebel,et al.  Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. , 2011, Colloids and surfaces. B, Biointerfaces.

[9]  Arnold I Caplan,et al.  The MSC: an injury drugstore. , 2011, Cell stem cell.

[10]  Y. Yoon,et al.  Malignant Tumor Formation After Transplantation of Short-Term Cultured Bone Marrow Mesenchymal Stem Cells in Experimental Myocardial Infarction and Diabetic Neuropathy , 2011, Circulation research.

[11]  J. Padbury,et al.  Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells. , 2011, The American journal of pathology.

[12]  Karen Bieback,et al.  Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells , 2011, Stem cells international.

[13]  M. Andreeff,et al.  Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth? , 2010, Stem cells.

[14]  W. Reith.  [White matter lesions in neonates]. , 2010, Klinische Padiatrie.

[15]  R. Schumacher,et al.  Isolation of Tracheal Aspirate Mesenchymal Stromal Cells Predicts Bronchopulmonary Dysplasia , 2010, Pediatrics.

[16]  U. Sack,et al.  Therapeutic Implications of the IL-21: IL-4 Receptor System in Children with Common Variable Immunodeficiency Syndrome , 2010, Klinische Padiatrie.

[17]  K. Bieback,et al.  Mesenchymal stromal cells from human perinatal tissues: From biology to cell therapy. , 2010, World journal of stem cells.

[18]  R. Ehrenkranz,et al.  Does bronchopulmonary dysplasia contribute to the occurrence of cerebral palsy among infants born before 28 weeks of gestation? , 2010, Archives of Disease in Childhood: Fetal and Neonatal Edition.

[19]  L. Gortner,et al.  Rates of Bronchopulmonary Dysplasia in Very Preterm Neonates in Europe: Results from the MOSAIC Cohort , 2010, Neonatology.

[20]  Jakub Tolar,et al.  Concise Review: Hitting the Right Spot with Mesenchymal Stromal Cells , 2010, Stem cells.

[21]  Jian-cheng Xu,et al.  INTRAVENOUS DELIVERY OF BONE MARROW-DERIVED ENDOTHELIAL PROGENITOR CELLS IMPROVES SURVIVAL AND ATTENUATES LIPOPOLYSACCHARIDE-INDUCED LUNG INJURY IN RATS , 2010, Shock.

[22]  A. Greenough,et al.  Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial , 2010, The Lancet.

[23]  A. Kavelaars,et al.  Repeated Mesenchymal Stem Cell Treatment after Neonatal Hypoxia–Ischemia Has Distinct Effects on Formation and Maturation of New Neurons and Oligodendrocytes Leading to Restoration of Damage, Corticospinal Motor Tract Activity, and Sensorimotor Function , 2010, The Journal of Neuroscience.

[24]  Qingbo Xu,et al.  Endothelial precursors in vascular repair. , 2010, Microvascular research.

[25]  Gerard Pasterkamp,et al.  Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. , 2010, Stem cell research.

[26]  L. Doyle,et al.  Dexamethasone Treatment in the First Week of Life for Preventing Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review , 2010, Neonatology.

[27]  Stefano Di Girolamo,et al.  Preterm birth and neurodevelopmental outcome: a review , 2010, Child's Nervous System.

[28]  Frank van Bel,et al.  Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration , 2010, Brain, Behavior, and Immunity.

[29]  M. Yoder,et al.  Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice. , 2010, American journal of physiology. Lung cellular and molecular physiology.

[30]  W. Göpel,et al.  Surfactant without Intubation in Preterm Infants with Respiratory Distress: First Multi-center Data , 2010, Klinische Padiatrie.

[31]  Chang Won Choi,et al.  Mesenchymal Stem-Cell Transplantation for Hypoxic-Ischemic Brain Injury in Neonatal Rat Model , 2010, Pediatric Research.

[32]  A. Agustí,et al.  Abnormal Levels of Circulating Endothelial Progenitor Cells During Exacerbations of COPD , 2010, Lung.

[33]  S. Archer,et al.  Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. , 2009, American journal of respiratory and critical care medicine.

[34]  O. Liang,et al.  Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. , 2009, American journal of respiratory and critical care medicine.

[35]  S. Rankin,et al.  CXCR2 Mediates the Recruitment of Endothelial Progenitor Cells During Allergic Airways Remodeling , 2009, Stem cells.

[36]  S. Abman,et al.  Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. , 2009, American journal of physiology. Lung cellular and molecular physiology.

[37]  J. Tolar,et al.  Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells , 2009, British journal of haematology.

[38]  A. de Silvestri,et al.  Circulating endothelial progenitor cells in preterm infants with bronchopulmonary dysplasia. , 2009, American journal of respiratory and critical care medicine.

[39]  M. Yoder,et al.  The definition of EPCs and other bone marrow cells contributing to neoangiogenesis and tumor growth: is there common ground for understanding the roles of numerous marrow-derived cells in the neoangiogenic process? , 2009, Biochimica et biophysica acta.

[40]  Terrie E Inder,et al.  Neurobehavior at term and white and gray matter abnormalities in very preterm infants. , 2009, The Journal of pediatrics.

[41]  K. S. Silva,et al.  Predictive factors for neuromotor abnormalities at the corrected age of 12 months in very low birth weight premature infants. , 2009, Arquivos de neuro-psiquiatria.

[42]  S. Majka,et al.  Neovascular capacity of endothelial progenitor cells in the adult pulmonary circulation. , 2009, American journal of physiology. Lung cellular and molecular physiology.

[43]  M. A. Curotto de Lafaille,et al.  Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? , 2009, Immunity.

[44]  R. Soll,et al.  Animal derived surfactant extract for treatment of respiratory distress syndrome. , 2009, The Cochrane database of systematic reviews.

[45]  B. Schmidt,et al.  Using a Count of Neonatal Morbidities to Predict Poor Outcome in Extremely Low Birth Weight Infants: Added Role of Neonatal Infection , 2009, Pediatrics.

[46]  K. Bieback,et al.  Non-hematopoietic Stem and Progenitor Cells Derived From Human Umbilical Cord Blood , 2009 .

[47]  D. Hess,et al.  Intravenous Grafts Recapitulate the Neurorestoration Afforded by Intracerebrally Delivered Multipotent Adult Progenitor Cells in Neonatal Hypoxic-Ischemic Rats , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[48]  D. Ferriero,et al.  Therapeutics for neonatal brain injury. , 2008, Pharmacology & therapeutics.

[49]  J. Tyson,et al.  Outcomes of Safety and Effectiveness in a Multicenter Randomized, Controlled Trial of Whole-Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy , 2008, Pediatrics.

[50]  W. Thomas,et al.  Nonventilatory Strategies for Prevention and Treatment of Bronchopulmonary Dysplasia – What Is the Evidence? , 2008, Neonatology.

[51]  D. Strunk,et al.  Clinical Protocols for the Isolation and Expansion of Mesenchymal Stromal Cells , 2008, Transfusion Medicine and Hemotherapy.

[52]  L. Ortiz,et al.  Stem cells and cell therapies in lung biology and lung diseases. , 2008, Proceedings of the American Thoracic Society.

[53]  B. Giebel,et al.  Lineage development of hematopoietic stem and progenitor cells , 2008, Biological chemistry.

[54]  Anne Greenough,et al.  Long-Term Pulmonary Outcome in the Preterm Infant , 2008, Neonatology.

[55]  Clive Wasserfall,et al.  Autologous umbilical cord blood infusion for type 1 diabetes. , 2008, Experimental hematology.

[56]  K. Bieback.  Basic Biology of Mesenchymal Stem Cells , 2008, Transfusion Medicine and Hemotherapy.

[57]  P. Bianco,et al.  Mesenchymal stem cells: revisiting history, concepts, and assays. , 2008, Cell stem cell.

[58]  P. Doevendans,et al.  Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. , 2008, Stem cell research.

[59]  Jae W. Lee,et al.  Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice1 , 2007, The Journal of Immunology.

[60]  J. Stolk,et al.  Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema , 2007, International journal of chronic obstructive pulmonary disease.

[61]  J. Wagner,et al.  Double umbilical cord blood transplantation. , 2006, Current opinion in immunology.

[62]  A. Caplan,et al.  Mesenchymal stem cells as trophic mediators , 2006, Journal of cellular biochemistry.

[63]  J. Wagner,et al.  Adult umbilical cord blood transplantation: a comprehensive review , 2006, Bone Marrow Transplantation.

[64]  Hermann Eichler,et al.  Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue , 2006, Stem cells.

[65]  H. Boezen,et al.  Lung function and exercise capacity in young adults born prematurely. , 2006, American journal of respiratory and critical care medicine.

[66]  D. Hess,et al.  Behavioral and Histological Characterization of Intrahippocampal Grafts of Human Bone Marrow-Derived Multipotent Progenitor Cells in Neonatal Rats with Hypoxic-Ischemic Injury , 2006, Cell transplantation.

[67]  Rinat Abramovitch,et al.  VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells , 2006, Cell.

[68]  S. Shankaran,et al.  Selective Head Cooling With Mild Systemic Hypothermia After Neonatal Encephalopathy: Multicentre Randomised Trial , 2006 .

[69]  R. Loi,et al.  Acute lung injury with endotoxin or NO2 does not enhance development of airway epithelium from bone marrow. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[70]  M. Yoder,et al.  Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. , 2005, Blood.

[71]  S. Sakaguchi.  Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self , 2005, Nature Immunology.

[72]  N Marlow,et al.  The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth , 2005, Archives of Disease in Childhood - Fetal and Neonatal Edition.

[73]  R. Geffers,et al.  CD4 T Lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions. , 2004, American journal of respiratory and critical care medicine.

[74]  D. Ferriero.  Neonatal brain injury. , 2004, The New England journal of medicine.

[75]  H. Klüter,et al.  Critical Parameters for the Isolation of Mesenchymal Stem Cells from Umbilical Cord Blood , 2004, Stem cells.

[76]  R. Pattinson,et al.  Intrapartum-related birth asphyxia in South Africa--lessons from the first national perinatal care survey. , 2002, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[77]  David A. Greenberg,et al.  Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[78]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[79]  P. D’Amore,et al.  Vascular Development: Cellular and Molecular Regulation , 2022 .

[80]  Takayuki Asahara,et al.  Isolation of Putative Progenitor Endothelial Cells for Angiogenesis , 1997, Science.

[81]  C. Melief,et al.  B lymphocytes secrete antigen-presenting vesicles , 1996, The Journal of experimental medicine.

[82]  I. Milsom,et al.  Birth asphyxia: incidence, clinical course and outcome in a Swedish population , 1995, Acta paediatrica.

[83]  C. Schatschneider,et al.  School-age outcomes in children with birth weights under 750 g. , 1995, The New England journal of medicine.

[84]  J. Wagner,et al.  Cord blood banking for hematopoietic stem cell transplantation: an international cord blood transplant registry. , 1993, Bone marrow transplantation.

[85]  J. Kurtzberg,et al.  Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. , 1989, The New England journal of medicine.

[86]  R. Johnstone,et al.  Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). , 1987, The Journal of biological chemistry.

[87]  P. Stahl,et al.  Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes , 1983, The Journal of cell biology.