Simulating electric activities of neurons by using PSPICE

Electric activities in the Morris–Lecar neuron and Josephson junction coupled resonator are investigated in a numerical way, and electric circuits are also designed by using the Personal Simulation Program with Integrated Circuit Emphasis (PSPICE). Within the improved Morris–Lecar circuit, a new integrator for the ion channel of potassium is designed, and the transition of electric activities, quiescent state to spiking to bursting to quiescent state could be observed. In the circuit of the Josephson-junction coupled resonator, an equivalent circuit is designed to reproduce several types of electric activity. The detailed parameter regions are detected to generate spiking and bursting states in the electric circuits for neurons, and these results are consistent with the numerical results. Bifurcation diagrams for interspike interval (ISI) vs. the forcing current are calculated to detect the excitability of the neuron model.

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