In order to improve fuel efficiency and power density, the boost pressure of diesel engine is increasing continuously. The increase in boost level leads to some problems, such as lack of air under part load operating conditions, response delay during transient processes, and high mechanical and thermal load. In order to meet the high boost level demand, a new type of turbocharging system—mixed pulse converter (MIXPC) turbocharging system for multicylinder diesel engines (from 4 to 20 cylinders) has been invented. A turbocharged diesel engine simulation model, based on one-dimensional finite volume method (FVM) and total variation diminishing (TVD) scheme, has been developed and used to design and analyze the MIXPC turbocharging system. The applications of MIXPC system in in-line 8- and 4-cylinder and V-type 16-cylinder medium-speed marine diesel engines have been studied by calculation and experiments. The results show that the invented MIXPC system has superior engine fuel efficiency and thermal load compared with original turbocharging systems.