The inheritance of immunoglobulin E: genetic linkage analysis.

Linkage analyses between 21 genetic markers including HLA-A, B, and the postulated locus for determining total serum IgE levels were done to try to clarify the inheritance of total IgE levels and to map the locus. A total of 316 individuals from five Mormon kindreds were studied, and data from an additional 204 Amish individuals from 11 families were analyzed for possible HLA linkage. Segregation analyses of both data sets did not give clear definition of the mode of inheritance of total IgE levels, but purely environmental models were rejected. Linkage analyses gave significant evidence against HLA linkage with the codominant, recessive, or dominant model of inheritance for total IgE levels. No significant evidence for linkage with any of the genetic markers was obtained. Since total serum IgE levels are correlated with allergies, understanding the genetics of total IgE levels is important to understanding the genetics of allergic disease in man.

[1]  S J Hasstedt,et al.  A mixed-model likelihood approximation on large pedigrees. , 1982, Computers and biomedical research, an international journal.

[2]  D. Meyers,et al.  HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure , 1982, The Journal of experimental medicine.

[3]  D. Meyers,et al.  HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. II. Response after ragweed immunotherapy , 1982, The Journal of experimental medicine.

[4]  D. Meyers,et al.  The epidemiology and genetics of atopic allergy. , 1981, The New England journal of medicine.

[5]  D. Meyers,et al.  Report on a National Institute of Allergy and Infectious Diseases-sponsored workshop on the genetics of total immunoglobulin E levels in humans. , 1981, The Journal of allergy and clinical immunology.

[6]  N. Morton,et al.  Immunoglobulin E revisited. , 1980, American journal of human genetics.

[7]  R. Elston,et al.  Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. , 1980, Science.

[8]  N. Mendell,et al.  Genetic linkage between hereditary hemochromatosis and HLA. , 1979, American journal of human genetics.

[9]  J. Ott,et al.  Maximum likelihood estimation by counting methods under polygenic and mixed models in human pedigrees. , 1979, American journal of human genetics.

[10]  R. Schellenberg,et al.  Measurement of absolute amounts of antigen-specific human IgE by a radioallergosorbent test (RAST) elution technique. , 1975, Journal of immunology.

[11]  D. Marsh,et al.  Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Ott.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. , 1974, American journal of human genetics.

[13]  N. Morton.  Sequential tests for the detection of linkage. , 1955, American journal of human genetics.

[14]  D. Meyers,et al.  Inheritance of immunoglobulin E: genetic model fitting. , 1983, American journal of medical genetics.

[15]  D. Meyers,et al.  A genetic study of total IgE levels in the Amish. , 1982, Human heredity.

[16]  D. Meyers,et al.  Association of HLA phenotypes A1, B8, DW3 and A3, B7, DW2 with allergy. , 1981, International archives of allergy and applied immunology.

[17]  N. Mendell,et al.  Genetic transmission of serum IgE Levels. , 1981, American journal of medical genetics.

[18]  N E Morton,et al.  A genetic study of immunoglobulin E. , 1978, American journal of human genetics.

[19]  K. Ishizaka.  Cellular events in the IgE antibody response. , 1976, Advances in immunology.