Apocrine Adenocarcinoma of Lacrimal Sac Presenting as Chronic Dacryocystitis

The objective of this paper is to report a case of lacrimal apocrine adenocarcinoma which presented as chronic dacryocystitis. A 62-year-old male was referred by his primary ophthalmologist for evaluation of chronic dacryocystitis of the right eye for 3 months. Biopsy showed a rare and aggressive type of cancer: apocrine adenocarcinoma of the nasolacrimal sac and paranasal sinuses. The patient was treated with orbital exenteration followed by chemoradiation therapy. Apocrine adenocarcinoma, a rare tumor of the eyelid glands, can masquerade as chronic dacryocystitis.

[1]  D. Selva,et al.  Apocrine Adenocarcinoma of the Eyelid: Case Series and Review , 2013, Ophthalmic plastic and reconstructive surgery.

[2]  T. Fitzgerald,et al.  Cutaneous apocrine adenocarcinoma: Defining epidemiology, outcomes, and optimal therapy for a rare neoplasm , 2012, Journal of surgical oncology.

[3]  B. Esmaeli,et al.  Introduction of the 7th edition eyelid carcinoma classification system from the American Joint Committee on Cancer-International Union Against Cancer staging manual. , 2009, Archives of pathology & laboratory medicine.

[4]  M. Shintaku,et al.  Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: Report of a case , 2002, Pathology international.

[5]  F. Eckert,et al.  Apocrine cystadenoma, apocrine hidrocystoma, and eccrine hidrocystoma: three distinct tumors defined by expression of keratins and human milk fat globulin 1 , 1997, Journal of cutaneous pathology.

[6]  S. Kondo,et al.  An Immunohistochemical Study of Lysozyme, CD-15 (Leu M1), and Gross Cystic Disease Fluid Protein-15 in Various Skin Tumors: Assessment of the Specificity and Sensitivity of Markers of Apocrine Differentiation , 1995, The American Journal of dermatopathology.

[7]  N. Tanner,et al.  Carcinoma of the apocrine glands at the base of eyelashes; a case report and discussion of histological diagnostic criteria. , 1989, British journal of plastic surgery.

[8]  R. L. Warkel.  Selected apocrine neoplasms , 1984, Journal of cutaneous pathology.

[9]  S. Kieval,et al.  Tumours of the Moll's glands. , 1984, The British journal of ophthalmology.

[10]  M. Haust,et al.  Carcinoma of apocrine glands; report of case. , 1958, A.M.A. archives of dermatology.

[11]  A. Stout,et al.  Carcinoma of sweat glands , 1951, Cancer.