Time to diagnosis of intraspinal tumors

The aim of this study was to assess the time to diagnosis in patients with intraspinal tumors and to assess factors contributing to a long delay in some patients. Patients who were admitted at our hospital over a 15‐year period (1986–2000) with an intraspinal (either intradural or extradural) tumor were included. Records of patients were studied for variables such as sex, age, diagnosis, date of diagnosis, initial symptoms, symptoms at diagnosis, level of tumor, original diagnosis and diagnostic technique [CT‐myelography, CT‐caudography or magnetic resonance imaging (MRI)]. The median time to diagnosis of 108 patients with an intraspinal tumor was 12.3 months (range: 4 days–14.4 years). Most common initial symptoms were back and/or neck pain, pain radiating to one extremity and walking disturbances. There was no distinctive clinical pattern between intramedullary and extramedullary tumors regarding initial symptoms. At the time of diagnosis, patients presented with moderate to severe neurological deficits: weakness in one extremity in 26%, sphincter disturbance (20%) and paraparesis (12%). Improved imaging of the spinal cord by MRI did not result in earlier detection of the intraspinal tumor. The time to diagnosis is explained by non‐specific and slowly progressing signs and symptoms. A high rate of clinical suspicion should be present to diagnose an intraspinal tumor at an early stage.

[1]  J. Klasen,et al.  Spinal tumors in coexisting degenerative spine disease—a differential diagnostic problem , 2004, European Spine Journal.

[2]  Lee Rr MR imaging of intradural tumors of the cervical spine. , 2000 .

[3]  R. R. Lee MR imaging of intradural tumors of the cervical spine. , 2000, Magnetic resonance imaging clinics of North America.

[4]  H. Crockard,et al.  Spinal intradural tumours: Part I--Extramedullary. , 1999, British journal of neurosurgery.

[5]  A. Singh,et al.  Spinal intradural tumours: Part II--Intramedullary. , 1999, British journal of neurosurgery.

[6]  D. Borenstein A clinician's approach to acute low back pain. , 1997, The American journal of medicine.

[7]  R. Robinson,et al.  Difficulties in diagnosing intrinsic spinal cord tumours. , 1996, Archives of disease in childhood.

[8]  A. Helseth The incidence of primary central nervous system neoplasms before and after computerized tomography availability. , 1995, Journal of neurosurgery.

[9]  N. Todd,et al.  Diagnosis of intradural conus and cauda equina tumours. , 1993, British journal of hospital medicine.

[10]  C. Galasko,et al.  Delay in Diagnosis of Intradural Spinal Tumors , 1992, Spine.

[11]  K. Iihara,et al.  Clinical features of intradural neurinomas in the cauda equina and around the conus medullaris. , 1992, Neurochirurgia.

[12]  R. West,et al.  An epidemiological survey of primary tumours of the brain and spinal cord in South East Wales. , 1989, British Journal of Neurosurgery.

[13]  M. Schirmer,et al.  [Spinal tumors]. , 1989, Deutsche Krankenpflegezeitschrift.

[14]  M. Fearnside,et al.  Tumours of the Cauda Equina , 1931, Edinburgh medical journal.