The Heterogeneous Mineral Content of Bone—Using Stochastic Arguments and Simulations to Overcome Experimental Limitations

[1]  Georg N Duda,et al.  Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae. , 2009, Bone.

[2]  Richard Weinkamer,et al.  Effect of Temporal Changes in Bone Turnover on the Bone Mineralization Density Distribution: A Computer Simulation Study , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  G Boivin,et al.  The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients. , 2008, Bone.

[4]  P. Fratzl,et al.  Bone mineralization density distribution in health and disease. , 2008, Bone.

[5]  Per Christian Hansen,et al.  Regularization Tools version 4.0 for Matlab 7.3 , 2007, Numerical Algorithms.

[6]  Richard Weinkamer,et al.  Nature’s hierarchical materials , 2007 .

[7]  P. Fratzl,et al.  The bone mineralization density distribution as a fingerprint of the mineralization process. , 2007, Bone.

[8]  Alexander G Robling,et al.  Biomechanical and molecular regulation of bone remodeling. , 2006, Annual review of biomedical engineering.

[9]  P. Delmas,et al.  Bone quality--the material and structural basis of bone strength and fragility. , 2006, The New England journal of medicine.

[10]  E. Ritman,et al.  The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover. , 2005, Bone.

[11]  B. L. Riggs,et al.  Drugs Used to Treat Osteoporosis: The Critical Need for a Uniform Nomenclature Based on Their Action on Bone Remodeling , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[12]  H Follet,et al.  The degree of mineralization is a determinant of bone strength: a study on human calcanei. , 2004, Bone.

[13]  P. Meunier,et al.  Methodological considerations in measurement of bone mineral content , 2003, Osteoporosis International.

[14]  P. Meunier,et al.  The mineralization of bone tissue: a forgotten dimension in osteoporosis research , 2003, Osteoporosis International.

[15]  P. Fratzl,et al.  Constant mineralization density distribution in cancellous human bone. , 2003, Bone.

[16]  P. Fratzl,et al.  Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. , 2003, The Journal of clinical endocrinology and metabolism.

[17]  F Peyrin,et al.  Synchrotron Radiation Microtomography Allows the Analysis of Three‐Dimensional Microarchitecture and Degree of Mineralization of Human Iliac Crest Biopsy Specimens: Effects of Etidronate Treatment , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  John D. Currey,et al.  Bones: Structure and Mechanics , 2002 .

[19]  P. Meunier,et al.  The Degree of Mineralization of Bone Tissue Measured by Computerized Quantitative Contact Microradiography , 2002, Calcified Tissue International.

[20]  T S Smith,et al.  Three‐dimensional microimaging (MRμI and μCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosis , 2001, The Anatomical record.

[21]  E. Vajda,et al.  Primary difficulties in quantitative backscattered electron (BSE) imaging. , 1999, Bone.

[22]  P. Fratzl,et al.  Response to the Letter to the Editor by E. G. Vajda and J. G. Skedros , 1999 .

[23]  P. Fratzl,et al.  Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. , 1998, Bone.

[24]  K. Bachus,et al.  Determining mineral content variations in bone using backscattered electron imaging. , 1997, Bone.

[25]  H. Engl,et al.  Regularization of Inverse Problems , 1996 .

[26]  H. Plenk,et al.  A new scanning electron microscopy approach to the quantification of bone mineral distribution: backscattered electron image grey-levels correlated to calcium K alpha-line intensities. , 1995, Scanning microscopy.

[27]  A. Parfitt Osteonal and hemi‐osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone , 1994, Journal of cellular biochemistry.

[28]  George Sanger,et al.  Structure and Mechanics , 1991 .

[29]  A. Boyde,et al.  Changes in the mineral density distribution in human bone with age: Image analysis using backscattered electrons in the SEM , 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  A. Boyde,et al.  A new method of scanning electron microscopy for imaging biological tissues , 1983, Nature.

[31]  Gene H. Golub,et al.  Singular value decomposition and least squares solutions , 1970, Milestones in Matrix Computation.

[32]  A. Silman,et al.  Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS) , 2003, Osteoporosis International.

[33]  Kentaro Uesugi,et al.  Bone structure and mineralization demonstrated using synchrotron radiation computed tomography (SR-CT) in animal models: preliminary findings , 2003, Journal of Bone and Mineral Metabolism.

[34]  A. Parfitt Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression. , 2002, Bone.

[35]  C. Turner Biomechanics of Bone: Determinants of Skeletal Fragility and Bone Quality , 2002, Osteoporosis International.

[36]  P. Fratzl,et al.  Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies : letter to the editor , 1999 .

[37]  K. Bachus,et al.  Influence of mineral content and composition on graylevels in backscattered electron images of bone. , 1993, Journal of biomedical materials research.