Ubiquitination and deubiquitination of ERBB receptors

Proefschrift ter verkrijging van de graad van doctor aan de Radboud Universiteit Nijmegen op gezag van de rector magnificus prof. mr. Table of contents

[1]  E. J. V. van Zoelen,et al.  The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation. , 2013, Cellular signalling.

[2]  M. Loda,et al.  The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation , 2013, Oncogene.

[3]  E. J. V. van Zoelen,et al.  Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively. , 2013, Cellular signalling.

[4]  E. J. V. van Zoelen,et al.  Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH. , 2012, Cellular signalling.

[5]  Ivan Dikic,et al.  Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. , 2012, Annual review of biochemistry.

[6]  A. Sorkin,et al.  The Role of EGF Receptor Ubiquitination in Regulating Its Intracellular Traffic , 2012, Traffic.

[7]  J. Maupin-Furlow Proteasomes and protein conjugation across domains of life , 2011, Nature Reviews Microbiology.

[8]  G. Mills,et al.  Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression , 2011, Oncogene.

[9]  A. Weissman,et al.  RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis , 2011, Nature Reviews Cancer.

[10]  T. Kurosu,et al.  c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway* , 2011, The Journal of Biological Chemistry.

[11]  L. Kane Faculty Opinions recommendation of K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. , 2011 .

[12]  L. E. Johannessen,et al.  A Chimeric Pre‐ubiquitinated EGF Receptor is Constitutively Endocytosed in a Clathrin‐Dependent, but Kinase‐Independent Manner , 2011, Traffic.

[13]  I. Touw,et al.  The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor. , 2011, The Biochemical journal.

[14]  J. E. V. van Leeuwen,et al.  ERBB2 is a target for USP8-mediated deubiquitination. , 2011, Cellular signalling.

[15]  A. Sorkin,et al.  Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking. , 2010, Experimental cell research.

[16]  David Komander,et al.  Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne , 2010, Nature Structural &Molecular Biology.

[17]  J. Yates,et al.  K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. , 2010, Immunity.

[18]  Z. Pan,et al.  Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. , 2010, Molecular cell.

[19]  M. Rapé,et al.  Building ubiquitin chains: E2 enzymes at work , 2009, Nature Reviews Molecular Cell Biology.

[20]  I. Madshus,et al.  Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking , 2009, Journal of Cell Science.

[21]  Soichi Wakatsuki,et al.  Ubiquitin-binding domains — from structures to functions , 2009, Nature Reviews Molecular Cell Biology.

[22]  W. Muller,et al.  c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential , 2009, Molecular and Cellular Biology.

[23]  Yusuke Sato,et al.  Structural basis for specific recognition of Lys 63‐linked polyubiquitin chains by tandem UIMs of RAP80 , 2009, The EMBO journal.

[24]  Aydin Haririnia,et al.  Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. , 2009, Molecular cell.

[25]  David Komander,et al.  Breaking the chains: structure and function of the deubiquitinases , 2009, Nature Reviews Molecular Cell Biology.

[26]  J. Borg,et al.  Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis , 2009, Circulation research.

[27]  V. Venkataramanan,et al.  The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization , 2009, The EMBO journal.

[28]  D. Finley,et al.  Recognition and processing of ubiquitin-protein conjugates by the proteasome. , 2009, Annual review of biochemistry.

[29]  R. Deshaies,et al.  RING domain E3 ubiquitin ligases. , 2009, Annual review of biochemistry.

[30]  R. Harris,et al.  Nedd4 mediates ErbB4 JM‐a/CYT–1 ICD ubiquitination and degradation in MDCK II cells , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  E. J. V. van Zoelen,et al.  ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site. , 2009, Cellular signalling.

[32]  David Komander,et al.  Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains , 2009, EMBO reports.

[33]  J. Bomberger,et al.  The Deubiquitinating Enzyme USP10 Regulates the Post-endocytic Sorting of Cystic Fibrosis Transmembrane Conductance Regulator in Airway Epithelial Cells* , 2009, The Journal of Biological Chemistry.

[34]  A. Sobel,et al.  The Journal of Biological Chemistry. , 2009, Nutrition reviews.

[35]  Tao Wang,et al.  Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. , 2009, Journal of molecular biology.

[36]  Yasushi Saeki,et al.  Lysine 63‐linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome , 2009, The EMBO journal.

[37]  Zhijian J. Chen,et al.  Nonproteolytic functions of ubiquitin in cell signaling. , 2009, Molecular cell.

[38]  R. Boelens,et al.  E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity. , 2009, Journal of molecular biology.

[39]  Melissa A. Sandahl,et al.  The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation , 2008, Molecular and Cellular Biology.

[40]  Gordon B. Mills,et al.  Derailed endocytosis: an emerging feature of cancer , 2008, Nature Reviews Cancer.

[41]  H. Stenmark,et al.  Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. , 2008, Molecular biology of the cell.

[42]  O. Larsson,et al.  Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. , 2008, Cancer research.

[43]  K. Wilkinson,et al.  Recognition of Polyubiquitin Isoforms by the Multiple Ubiquitin Binding Modules of Isopeptidase T* , 2008, Journal of Biological Chemistry.

[44]  Ivan Dikic,et al.  Proteasome subunit Rpn13 is a novel ubiquitin receptor , 2008, Nature.

[45]  A. Uitterlinden,et al.  Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner , 2008, Journal of cellular biochemistry.

[46]  Wannian Yang,et al.  Identification of the domain in ErbB2 that restricts ligand-induced degradation. , 2008, Cellular signalling.

[47]  Zhixiang Wang,et al.  A Tale of Two Cbls: Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation , 2008, Molecular and Cellular Biology.

[48]  A. Ashworth,et al.  The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. , 2008, Molecular cell.

[49]  M. Bienz,et al.  Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. , 2008, Genes & development.

[50]  P. Bastiaens,et al.  Prolonged EGFR Signaling by ERBB2‐Mediated Sequestration at the Plasma Membrane , 2008, Traffic.

[51]  John P. Johnson,et al.  The Deubiquitinating Enzyme UCH-L3 Regulates the Apical Membrane Recycling of the Epithelial Sodium Channel* , 2007, Journal of Biological Chemistry.

[52]  Xiaohua Li,et al.  Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. , 2007, Molecular biology of the cell.

[53]  E. Pietras,et al.  A Deubiquitinase That Regulates Type I Interferon Production , 2007, Science.

[54]  M. MacCoss,et al.  Quantitative Profiling of Ubiquitylated Proteins Reveals Proteasome Substrates and the Substrate Repertoire Influenced by the Rpn10 Receptor Pathway*S , 2007, Molecular & Cellular Proteomics.

[55]  A. Sorkin,et al.  EGF receptor ubiquitination is not necessary for its internalization , 2007, Proceedings of the National Academy of Sciences.

[56]  Y. Yarden,et al.  Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains , 2007, Oncogene.

[57]  D. Payan,et al.  Substrate Modification with Lysine 63-linked Ubiquitin Chains through the UBC13-UEV1A Ubiquitin-conjugating Enzyme* , 2007, Journal of Biological Chemistry.

[58]  M. Komada,et al.  14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase. , 2007, Experimental cell research.

[59]  K. Du,et al.  Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery. , 2007, Molecular biology of the cell.

[60]  Hua Han,et al.  Degradation of HER2 by Cbl-based chimeric ubiquitin ligases. , 2007, Cancer research.

[61]  G. Kozlov,et al.  Structural Basis for UBA-mediated Dimerization of c-Cbl Ubiquitin Ligase* , 2007, Journal of Biological Chemistry.

[62]  G. Cesareni,et al.  The FASEB Journal • Research Communication The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation , 2022 .

[63]  Kalle Gehring,et al.  Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. , 2007, Molecular cell.

[64]  J. E. V. van Leeuwen,et al.  UBPY-mediated Epidermal Growth Factor Receptor (EGFR) De-ubiquitination Promotes EGFR Degradation* , 2007, Journal of Biological Chemistry.

[65]  Kermit L. Carraway,et al.  Neuregulin-Induced ErbB3 Downregulation Is Mediated by a Protein Stability Cascade Involving the E3 Ubiquitin Ligase Nrdp1 , 2007, Molecular and Cellular Biology.

[66]  P. Brzovic,et al.  Ubiquitin Transfer from the E2 Perspective: Why is UbcH5 So Promiscuous? , 2006, Cell cycle.

[67]  R. Piper,et al.  Epidermal Growth Factor Receptor Fate Is Controlled by Hrs Tyrosine Phosphorylation Sites That Regulate Hrs Degradation , 2006, Molecular and Cellular Biology.

[68]  M. J. Clague,et al.  Endocytosis: the DUB version. , 2006, Trends in cell biology.

[69]  J. Martin-Serrano,et al.  Interaction of AMSH with ESCRT-III and Deubiquitination of Endosomal Cargo* , 2006, Journal of Biological Chemistry.

[70]  I. Prior,et al.  The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation* , 2006, Journal of Biological Chemistry.

[71]  C. Fathman,et al.  CYLD: deubiquitination-induced TCR signaling , 2006, Nature Immunology.

[72]  Xuejun Jiang,et al.  Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. , 2006, Molecular cell.

[73]  R. Beynon,et al.  Activation of the Endosome-Associated Ubiquitin Isopeptidase AMSH by STAM, a Component of the Multivesicular Body-Sorting Machinery , 2006, Current Biology.

[74]  Ivan Dikic,et al.  The Cbl interactome and its functions , 2005, Nature Reviews Molecular Cell Biology.

[75]  L. E. Johannessen,et al.  The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane. , 2005, Molecular biology of the cell.

[76]  W. Muller,et al.  The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation , 2005, Oncogene.

[77]  Yigong Shi,et al.  Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14 , 2005, The EMBO journal.

[78]  M. Komada,et al.  Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. , 2005, Molecular biology of the cell.

[79]  M. Naujokas,et al.  Met/Hepatocyte Growth Factor Receptor Ubiquitination Suppresses Transformation and Is Required for Hrs Phosphorylation , 2005, Molecular and Cellular Biology.

[80]  Honglin Zhou,et al.  Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A , 2005, The Journal of cell biology.

[81]  M. J. Clague,et al.  Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. , 2005, The Biochemical journal.

[82]  D. Fushman,et al.  Diverse polyubiquitin interaction properties of ubiquitin-associated domains , 2005, Nature Structural &Molecular Biology.

[83]  Prachi M. Patil,et al.  Traffic , 2004, Voluminous States.

[84]  A. Amerik,et al.  Mechanism and function of deubiquitinating enzymes. , 2004, Biochimica et biophysica acta.

[85]  Steven P Gygi,et al.  Phosphoproteomic Analysis of the Developing Mouse Brain*S , 2004, Molecular & Cellular Proteomics.

[86]  J. McCullough,et al.  AMSH is an endosome-associated ubiquitin isopeptidase , 2004, The Journal of cell biology.

[87]  William Arbuthnot Sir Lane,et al.  Comprehensive Proteomic Analysis of Interphase and Mitotic 14-3-3-binding Proteins* , 2004, Journal of Biological Chemistry.

[88]  D. Finley,et al.  Rad23 and Rpn10 Serve as Alternative Ubiquitin Receptors for the Proteasome* , 2004, Journal of Biological Chemistry.

[89]  M. Nau,et al.  Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b , 2004, Oncogene.

[90]  Xuejun Jiang,et al.  Tyrosine Phosphorylation of the β2 Subunit of Clathrin Adaptor Complex AP-2 Reveals the Role of a Di-leucine Motif in the Epidermal Growth Factor Receptor Trafficking* , 2003, Journal of Biological Chemistry.

[91]  C. Preisinger,et al.  The UIM domain of Hrs couples receptor sorting to vesicle formation , 2003, Journal of Cell Science.

[92]  A. Saltiel,et al.  The Roles of Cbl-b and c-Cbl in Insulin-stimulated Glucose Transport* , 2003, Journal of Biological Chemistry.

[93]  E. J. V. van Zoelen,et al.  Ligand-induced Lysosomal Epidermal Growth Factor Receptor (EGFR) Degradation Is Preceded by Proteasome-dependent EGFR De-ubiquitination* , 2003, Journal of Biological Chemistry.

[94]  A. Citri,et al.  Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7. , 2003, Developmental cell.

[95]  Rick A. Rogers,et al.  Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis* , 2003, Journal of Biological Chemistry.

[96]  Yosef Yarden,et al.  Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation* , 2003, Journal of Biological Chemistry.

[97]  Pier Paolo Di Fiore,et al.  Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation , 2003, Nature Cell Biology.

[98]  D. Wazer,et al.  ErbB2 Degradation Mediated by the Co-chaperone Protein CHIP* , 2003, The Journal of Biological Chemistry.

[99]  Xuejun Jiang,et al.  Grb2 regulates internalization of EGF receptors through clathrin-coated pits. , 2003, Molecular biology of the cell.

[100]  A. Goldberg,et al.  Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[101]  T. Yao,et al.  A cryptic protease couples deubiquitination and degradation by the proteasome , 2002, Nature.

[102]  L. Neckers,et al.  Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[103]  G. Dittmar,et al.  Proteasome subunit Rpn1 binds ubiquitin-like protein domains , 2002, Nature Cell Biology.

[104]  I. Madshus,et al.  Phosphorylation of Hrs downstream of the epidermal growth factor receptor. , 2002, European journal of biochemistry.

[105]  Li Chen,et al.  Rad23 Promotes the Targeting of Proteolytic Substrates to the Proteasome , 2002, Molecular and Cellular Biology.

[106]  L. Mei,et al.  Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function , 2002, International Journal of Developmental Neuroscience.

[107]  J. Lippincott-Schwartz,et al.  Role of Grb2 in EGF-stimulated EGFR internalization. , 2002, Journal of cell science.

[108]  I. Madshus,et al.  Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes , 2002, Nature Cell Biology.

[109]  J. Zweier,et al.  A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal , 2002, Nature.

[110]  Y. Yarden,et al.  A mutant EGF‐receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling , 2002, The EMBO journal.

[111]  A. Goldberg,et al.  Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome. , 2001, Molecular cell.

[112]  Colin Gordon,et al.  Proteins containing the UBA domain are able to bind to multi-ubiquitin chains , 2001, Nature Cell Biology.

[113]  Li Chen,et al.  Ubiquitin‐associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi‐ubiquitin chain assembly , 2001, EMBO reports.

[114]  C. Pickart,et al.  In Vitro Assembly and Recognition of Lys-63 Polyubiquitin Chains* , 2001, The Journal of Biological Chemistry.

[115]  C. Pickart,et al.  Molecular Insights into Polyubiquitin Chain Assembly Crystal Structure of the Mms2/Ubc13 Heterodimer , 2001, Cell.

[116]  D. Birnbaum,et al.  The ERBB2/HER2 Receptor Differentially Interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 Domain Proteins* , 2001, The Journal of Biological Chemistry.

[117]  K. Miyazawa,et al.  A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP* , 2000, The Journal of Biological Chemistry.

[118]  Y. Yarden,et al.  c-Cbl Is a Suppressor of the Neu Oncogene* , 2000, The Journal of Biological Chemistry.

[119]  Ping Wang,et al.  Structure of a c-Cbl–UbcH7 Complex RING Domain Function in Ubiquitin-Protein Ligases , 2000, Cell.

[120]  Y. Yarden,et al.  Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. , 2000, Cancer research.

[121]  D. Birnbaum,et al.  ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor , 2000, Nature Cell Biology.

[122]  H. Band,et al.  The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor* , 2000, The Journal of Biological Chemistry.

[123]  Martin Rechsteiner,et al.  Recognition of the polyubiquitin proteolytic signal , 2000, The EMBO journal.

[124]  A Ciechanover,et al.  Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. , 1999, Molecular cell.

[125]  R. Baron,et al.  Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7* , 1999, The Journal of Biological Chemistry.

[126]  R. Baron,et al.  Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl , 1999, The Journal of Biological Chemistry.

[127]  T. Hunter,et al.  The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. , 1999, Science.

[128]  J. Brugge,et al.  Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers , 1999, Molecular and Cellular Biology.

[129]  J. Penninger,et al.  cbl-3: a new mammalian cbl family protein , 1999, Oncogene.

[130]  H. Wiley,et al.  ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors* , 1999, The Journal of Biological Chemistry.

[131]  M. Nau,et al.  cbl-b inhibits epidermal growth factor receptor signaling , 1999, Oncogene.

[132]  F. R. Papa,et al.  Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. , 1999, Molecular biology of the cell.

[133]  Z. Kam,et al.  c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. , 1998, Genes & development.

[134]  W. Baumeister,et al.  A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3 , 1998, Cell.

[135]  A. Lenferink,et al.  Differential endocytic routing of homo‐ and hetero‐dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers , 1998, The EMBO journal.

[136]  G. Carpenter,et al.  Constitutive Proteolysis of the ErbB-4 Receptor Tyrosine Kinase by a Unique, Sequential Mechanism , 1997, The Journal of cell biology.

[137]  A. Amerik,et al.  In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome , 1997, The EMBO journal.

[138]  R. Huber,et al.  Structure of 20S proteasome from yeast at 2.4Å resolution , 1997, Nature.

[139]  Wei Xu,et al.  Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome , 1997, Nature.

[140]  A. Sorkin,et al.  Epidermal Growth Factor Receptor Interaction with Clathrin Adaptors Is Mediated by the Tyr974-containing Internalization Motif* , 1996, The Journal of Biological Chemistry.

[141]  P. Bucher,et al.  The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. , 1996, Trends in biochemical sciences.

[142]  Y. Yarden,et al.  Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. , 1996, Oncogene.

[143]  G. Carpenter,et al.  All ErbB Receptors Other Than the Epidermal Growth Factor Receptor Are Endocytosis Impaired (*) , 1996, The Journal of Biological Chemistry.

[144]  Y. Yarden,et al.  Roles for a Cytoplasmic Tyrosine and Tyrosine Kinase Activity in the Interactions of Neu Receptors with Coated Pits (*) , 1995, The Journal of Biological Chemistry.

[145]  Q. Deveraux,et al.  A 26 S protease subunit that binds ubiquitin conjugates. , 1994, The Journal of biological chemistry.

[146]  G. Carpenter,et al.  The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired. , 1993, Oncogene.

[147]  J. Davies,et al.  Molecular Biology of the Cell , 1983, Bristol Medico-Chirurgical Journal.

[148]  P. Lawrence,et al.  Genes in development , 1977, Nature.

[149]  郭鹏 Nature Cell Biology:控制前列腺癌进展和转移的代谢总开关 , 2016 .

[150]  A. Ciechanover,et al.  The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation , 2011, Nature Reviews Molecular Cell Biology.

[151]  A. Sorkin,et al.  Endocytosis and intracellular trafficking of ErbBs. , 2008, Experimental cell research.

[152]  S. Gygi,et al.  Identification of 14-3-3epsilon substrates from embryonic murine brain. , 2006, Journal of proteome research.

[153]  L. Allen Stem cells. , 2003, The New England journal of medicine.

[154]  A. Goldberg,et al.  ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. , 2003, Molecular cell.

[155]  L. Mei,et al.  Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. , 2002, The Journal of biological chemistry.

[156]  J. Buxbaum,et al.  Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4. , 2000, The Journal of biological chemistry.

[157]  Juan S. Bonifacino,et al.  Current protocols in cell biology , 1998 .

[158]  Nihon Hassei Seibutsu Gakkai,et al.  Genes to cells , 1996 .

[159]  V. Hu The Cell Cycle , 1994, GWUMC Department of Biochemistry Annual Spring Symposia.

[160]  E. Kandel,et al.  Proceedings of the National Academy of Sciences of the United States of America. Annual subject and author indexes. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[161]  Experimental Cell Research , 1949, Nature.

[162]  E. F. ARMSTRONG,et al.  Annual Review of Biochemistry , 1944, Nature.

[163]  Shaheynoor Talukder,et al.  Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo , 2010, The EMBO journal.