Comparison of ethanol and other drugs of abuse concentrations in whole blood stored in venoject glass and plastic and venosafe plastic evacuated tubes.

The aim of this study was to evaluate the stability of blood concentrations of a variety of illegal and medicinal drugs that are important for forensic analyses when spiked and stored in Vacutainer or Venosafe evacuated plastic collection tubes compared to Vacutainer evacuated glass tubes. Tubes were filled with spiked whole blood and analyzed after storage for one week at ambient temperature and at -20 degrees C, respectively. Freeze-and-thaw stability was included in the study. No significant difference between storage in glass or plastic tubes was noted for any compound investigated.

[1]  A. Christophersen,et al.  Drug screening of whole blood by ultra-performance liquid chromatography-tandem mass spectrometry. , 2011, Journal of analytical toxicology.

[2]  D. Penetar,et al.  Comparison among plasma, serum, and whole blood ethanol concentrations: impact of storage conditions and collection tubes. , 2008, Journal of analytical toxicology.

[3]  L. Kristoffersen,et al.  Headspace gas chromatographic determination of ethanol: the use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma. , 2006, Forensic science international.

[4]  R. Janknegt,et al.  Do evacuated blood collection tubes interfere with therapeutic drug monitoring? , 1983, Pharmaceutisch Weekblad.

[5]  H. Druid,et al.  Stability of drugs in stored postmortem femoral blood and vitreous humor. , 2004, Journal of forensic sciences.

[6]  M. Parviainen,et al.  Suitability of Collection Tubes with Separator Gels for Collecting and Storing Blood Samples for Therapeutic Drug Monitoring (TDM) , 2000, Clinical chemistry and laboratory medicine.

[7]  A. Dasgupta,et al.  Stability of therapeutic drug measurement in specimens collected in VACUTAINER plastic blood-collection tubes. , 1996, Therapeutic drug monitoring.

[8]  R. Dean,et al.  Absorption of therapeutic drugs by barrier gels in serum separator blood collection tubes. Volume- and time-dependent reduction in total and free drug concentrations. , 1994, American journal of clinical pathology.

[9]  G. Hortin,et al.  Evaluation of evacuated blood-collection tubes: effects of three types of polymeric separators on therapeutic drug-monitoring specimens. , 1993, Clinical chemistry.

[10]  D. Bailey,et al.  Stability of Drug Concentrations in Plasma Stored in Serum Separator Blood Collection Tubes , 1988, Therapeutic drug monitoring.

[11]  G. Nyberg,et al.  Preparation of Serum and Plasma Samples for Determination of Tricyclic Antidepressants: Effects of Blood Collection Tubes and Storage , 1986, Therapeutic drug monitoring.

[12]  M. Sink,et al.  Blood Collection Tubes for Tricyclic Antidepressant Drugs: A Reevaluation , 1984, Therapeutic drug monitoring.

[13]  Müller Fo,et al.  Comparative effects of two commercially available blood collection tubes on plasma concentrations of drugs. , 1980 .