Analysis of the Chaotic Characteristics of Human Colonic Activities and Comparison of Healthy Participants to Costive Subjects

Constipation is a common yet distressing disease that has high rates of morbidity and impacts patients' quality of life. However, there is no perfect method to distinguish costive patients from healthy subjects. Is there chaos in human colonic activities? Are there any differences for the chaos indicators of colonic activities between healthy and costive subjects? Can these indicators distinguish patients with constipation from healthy subjects? To answer these questions, colonic pressure data from 16 healthy subjects and 48 patients with constipation were analyzed using the chaos theory. Three chaotic indicators [i.e., the largest Lyapunov exponent (LyE), correlation dimension (CorDim), and Kolmogorov entropy (KoEn)] were calculated and compared between groups with the Wilcoxon rank sum test. As a result, the LyE was greater than zero and the CorDim was fractioned, which showed that human colonic activities have clear chaotic characteristics. Statistically significant differences were observed between groups for CorDim (p <; 0.05), whereas LyE did not show statistically significant differences between groups. The chaotic indicator of CorDim was able to differentiate between patients with constipation and healthy subjects. The chaos theory provides a new method for learning the nonlinear dynamics of human gastrointestinal activities.

[1]  Guozheng Yan,et al.  A study of human colonic motility in healthy and constipated subjects using the wireless capsule , 2015, Comput. Biol. Medicine.

[2]  G. Yan,et al.  HUMAN GASTROINTESTINAL DATA ANALYSIS BASED ON WAVELET TRANSFORM-FRACTAL ALGORITHM CHARACTERIZED BY WIRELESS CAPSULE , 2015 .

[3]  Angela Man,et al.  The impact of ageing on the intestinal epithelial barrier and immune system. , 2014, Cellular immunology.

[4]  Jilei Zhou,et al.  Chaos optimization algorithms based on chaotic maps with different probability distribution and search speed for global optimization , 2014, Commun. Nonlinear Sci. Numer. Simul..

[5]  Siddharth Singh,et al.  Clinical utility of colonic manometry in slow transit constipation , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[6]  P. Bampton,et al.  High Resolution Colonic Manometry – What Have We Learnt?- a Review of the Literature 2012 , 2013, Current Gastroenterology Reports.

[7]  Xudong Guo,et al.  Nonlinear fractal dynamics of human colonic pressure activity based upon the box-counting method , 2013, Computer methods in biomechanics and biomedical engineering.

[8]  Jin-Wei Liang,et al.  Identification and verification of chaotic dynamics in a missile system from experimental time series , 2013, Int. J. Syst. Sci..

[9]  V. Smith,et al.  High‐resolution colonic manometry accurately predicts colonic neuromuscular pathological phenotype in pediatric slow transit constipation , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[10]  Dixiong Yang,et al.  Chaotic Characteristic Analysis of Strong Earthquake Ground Motions , 2012, Int. J. Bifurc. Chaos.

[11]  Da-Hai Xia,et al.  Determination of corrosion types from electrochemical noise by phase space reconstruction theory , 2012 .

[12]  Khoa Tran,et al.  Evaluation of regional and whole gut motility using the wireless motility capsule: relevance in clinical practice , 2012, Therapeutic advances in gastroenterology.

[13]  Mohammad Ali Ghorbani,et al.  Investigating chaos in river stage and discharge time series , 2012 .

[14]  M. Barthet,et al.  Dynamic Anal Endosonography and MRI Defecography in Diagnosis of Pelvic Floor Disorders: Comparison With Conventional Defecography , 2011, Diseases of the colon and rectum.

[15]  N. Stergiou,et al.  Human movement variability, nonlinear dynamics, and pathology: is there a connection? , 2011, Human movement science.

[16]  Hua-chong Ma,et al.  Colonic transit time in patient with slow-transit constipation: comparison of radiopaque markers and barium suspension method. , 2011, European Journal of Radiology.

[17]  Mohammad Hasan Moradi,et al.  Using phase space reconstruction for patient independent heartbeat classification in comparison with some benchmark methods , 2011, Comput. Biol. Medicine.

[18]  Braden Kuo,et al.  Generalized Transit Delay on Wireless Motility Capsule Testing in Patients with Clinical Suspicion of Gastroparesis, Small Intestinal Dysmotility, or Slow Transit Constipation , 2011, Digestive Diseases and Sciences.

[19]  J. Slavin,et al.  The use of a wireless motility device (SmartPill®) for the measurement of gastrointestinal transit time after a dietary fibre intervention. , 2011, The British journal of nutrition.

[20]  Zuhan Liu,et al.  A chaotic analysis on air pollution index change over past 10 years in Lanzhou, northwest China , 2011 .

[21]  Jianbo Gao,et al.  Complexity measures of brain wave dynamics , 2011, Cognitive Neurodynamics.

[22]  S. Rao,et al.  What is necessary to diagnose constipation? , 2011, Best practice & research. Clinical gastroenterology.

[23]  P. Dinning,et al.  Colonic dysmotility in constipation. , 2011, Best practice & research. Clinical gastroenterology.

[24]  J. Tack.  Current and future therapies for chronic constipation. , 2011, Best practice & research. Clinical gastroenterology.

[25]  Mohammad Ali Ghorbani,et al.  A probe into the chaotic nature of daily streamflow time series by correlation dimension and largest Lyapunov methods , 2010 .

[26]  B. Kuo,et al.  Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule , 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[27]  S M Scott,et al.  Wireless pH‐motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation , 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[28]  G. Eisen,et al.  Constipation is not associated with an increased rate of findings on colonoscopy: results from a national endoscopy consortium. , 2010, Endoscopy.

[29]  M. Benninga,et al.  No Change in Rectal Sensitivity After Gut-Directed Hypnotherapy in Children With Functional Abdominal Pain or Irritable Bowel Syndrome , 2010, The American Journal of Gastroenterology.

[30]  P. Dinning,et al.  Pathophysiology of colonic causes of chronic constipation , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[31]  H. Parkman,et al.  Wireless Capsule Motility: Comparison of the SmartPill® GI Monitoring System with Scintigraphy for Measuring Whole Gut Transit , 2009, Digestive Diseases and Sciences.

[32]  J. Tack,et al.  Treatment of chronic constipation: current pharmacologic approaches and future directions. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[33]  J. Dacher,et al.  Radiologic evaluation of pelvic floor disorders. , 2008, Gastroenterology clinics of North America.

[34]  Paolo Dario,et al.  An implantable ZigBee ready telemetric platform for in vivo monitoring of physiological parameters , 2008 .

[35]  W. Chey,et al.  Comparison of gastric emptying of a nondigestible capsule to a radio‐labelled meal in healthy and gastroparetic subjects , 2007, Alimentary pharmacology & therapeutics.

[36]  Jack J Jiang,et al.  Chaos in voice, from modeling to measurement. , 2006, Journal of voice : official journal of the Voice Foundation.

[37]  L. Laine,et al.  Clinical Utility of Diagnostic Tests for Constipation in Adults: A Systematic Review , 2005, The American Journal of Gastroenterology.

[38]  R. Kavlock,et al.  Ambulatory 24-Hour Colonic Manometry in Slow-Transit Constipation , 2004, American Journal of Gastroenterology.

[39]  R. Turnock,et al.  Colonic transit time--what is normal? , 2004, Journal of pediatric surgery.

[40]  R. Hagger,et al.  Colonic motor activity in slow‐transit idiopathic constipation as identified by 24‐h pancolonic ambulatory manometry , 2003, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[41]  P. Grassberger,et al.  Estimation of the Kolmogorov entropy from a chaotic signal , 1983 .

[42]  Huilong Duan,et al.  Similarity Measure Between Patient Traces for Clinical Pathway Analysis: Problem, Method, and Applications , 2014, IEEE Journal of Biomedical and Health Informatics.

[43]  G. Locke,et al.  American Gastroenterological Association technical review on constipation. , 2013, Gastroenterology.

[44]  W. Elshazly,et al.  Role of dynamic magnetic resonance imaging in management of obstructed defecation case series. , 2010, International journal of surgery.

[45]  Michael Camilleri,et al.  Phenotypic variation of colonic motor functions in chronic constipation. , 2010, Gastroenterology.

[46]  Stomach , 2006, The American Journal of Gastroenterology.