Vancomycin levels are frequently subtherapeutic in critically ill patients: a prospective observational study

Appropriate utilization of vancomycin is important to attain therapeutic targets while avoiding clinical failure and the development of antimicrobial resistance. Our aim was to observe the use of vancomycin in an intensive care population, with the main focus on achievement of therapeutic serum concentrations (15–20 mg/l) and to evaluate how this was influenced by dose regimens, use of guidelines and therapeutic drug monitoring.

[1]  J. Pachón,et al.  Optimizing the Clinical Use of Vancomycin , 2016, Antimicrobial Agents and Chemotherapy.

[2]  E. Barcia,et al.  Pharmacokinetics of vancomycin and dosing recommendations for trauma patients. , 2016, The Journal of antimicrobial chemotherapy.

[3]  S. Zhai,et al.  Association between the AUC0-24/MIC Ratio of Vancomycin and Its Clinical Effectiveness: A Systematic Review and Meta-Analysis , 2016, PloS one.

[4]  J. Al-Tawfiq,et al.  Safety and Outcome of Pharmacy-Led Vancomycin Dosing and Monitoring , 2015, Chemotherapy.

[5]  L. Leibovici,et al.  Association of vancomycin serum concentrations with efficacy in patients with MRSA infections: a systematic review and meta-analysis. , 2015, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[6]  M. Papas,et al.  A Randomized Trial of Loading Vancomycin in the Emergency Department , 2015, The Annals of pharmacotherapy.

[7]  S. Zhai,et al.  Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review , 2014, PloS one.

[8]  R. Schmid,et al.  Evaluation of a dosing regimen for continuous vancomycin infusion in critically ill patients: an observational study in intensive care unit patients. , 2014, Journal of critical care.

[9]  J. Rello,et al.  Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study , 2014, Critical Care.

[10]  G. Joynt,et al.  Augmented Renal Clearance in the ICU: Results of a Multicenter Observational Study of Renal Function in Critically Ill Patients With Normal Plasma Creatinine Concentrations* , 2014, Critical care medicine.

[11]  A. Dubin,et al.  Augmented renal clearance in critically ill patients: incidence, associated factors and effects on vancomycin treatment , 2014, Revista Brasileira de terapia intensiva.

[12]  V. Briedis,et al.  Augmented renal clearance – an evolving risk factor to consider during the treatment with vancomycin , 2013, Journal of clinical pharmacy and therapeutics.

[13]  S. Zhai,et al.  Benefits of Therapeutic Drug Monitoring of Vancomycin: A Systematic Review and Meta-Analysis , 2013, PloS one.

[14]  D. Siraj,et al.  Impact of Regular Collaboration Between Infectious Diseases and Critical Care Practitioners on Antimicrobial Utilization and Patient Outcome* , 2013, Critical care medicine.

[15]  A. Hapfelmeier,et al.  Continuous intravenous administration of vancomycin in medical intensive care unit patients. , 2013, Journal of critical care.

[16]  A. Bombassaro,et al.  Antimicrobial use in a critical care unit: a prospective observational study , 2012, The International journal of pharmacy practice.

[17]  F. Wilson,et al.  Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD) , 2011, Clinical nephrology.

[18]  M. Palomar,et al.  Management of Antimicrobial Use in the Intensive Care Unit , 2012, Drugs.

[19]  R. Kullar,et al.  Impact of vancomycin exposure on outcomes in patients with methicillin-resistant Staphylococcus aureus bacteremia: support for consensus guidelines suggested targets. , 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  D. Levine,et al.  Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.