The mesh of the multilayer gauze stage was simplified from the crossing arrangement to the unilateral arrangement, and the simplification from three-dimensional to the two-dimensional came true. The calculation capacity was effectively controlled by means of the periodic boundary. The numerical simulation of the multilayer gauze stage with different layers has been done. After the several calculation with different operating conditions, the resistance characteristic curves of the corresponding models was gave out. The relationship between the layers of the multilayer gauze stage and the resistance characteristic has been worked out. The experiments on resistance specialty of the multilayer gauze stage have been done on the special wind-tunnel. The experiment result was compared with the numerical simulation result, in order to provide the effective information for the further research.