Surface grafted core-shell chitosan-modified solid lipid nanoparticles: characterization and application in hydrophobic drug delivery

Hybrid nanoparticles combining the core of a solid lipid nanoparticle (SLN) system and chitosan (CS) shell were developed for the delivery of hydrophobic curcumin (cur). The curcumin loaded CS-SLNs nanoparticles were formulated by an amalgamation of double-emulsion evaporation and ionic gelation technique for stronger linkage between CS and SLN. The unmodified SLNs and surface modified core-shell CS-SLNs were characterized and compared for particle size, morphology, surface chemistry, and drug release. The CS-SLNs were found to be spherical nano-sized particles with the SLN core acting as a drug depot and outer chitosan shell providing stability and the controlled release of curcumin. Potential application in cancer drug delivery was evaluated by determination of in vitro cytotoxicity and apoptotic effect of encapsulated curcumin on MCF-7 cells. The results suggest that the prepared core-shell nanoparticles are promising delivery systems for poorly soluble drugs with low bioavailability.

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