Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease

This Commentary discusses how treatment with antibiotics in infancy shapes host immunity and influences susceptibility later in life to diseases mediated by the immune system.

[1]  D. Relman,et al.  Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation , 2010, Proceedings of the National Academy of Sciences.

[2]  Jon Genuneit,et al.  Exposure to environmental microorganisms and childhood asthma. , 2011, The New England journal of medicine.

[3]  Masahiro Yamamoto,et al.  ATP drives lamina propria TH17 cell differentiation , 2008, Nature.

[4]  M. Blaser,et al.  Antibiotics in early life alter the murine colonic microbiome and adiposity , 2012, Nature.

[5]  A. Rudensky,et al.  Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation , 2013, Nature.

[6]  J. Hughes,et al.  Trends in antimicrobial prescribing rates for children and adolescents. , 2002, JAMA.

[7]  S. Mazmanian,et al.  A microbial symbiosis factor prevents intestinal inflammatory disease , 2008, Nature.

[8]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[9]  S. Bonini,et al.  Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study , 2000, BMJ : British Medical Journal.

[10]  Hilary G. Morrison,et al.  Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation , 2009, Infection and Immunity.

[11]  Anders F. Andersson,et al.  Short-Term Antibiotic Treatment Has Differing Long-Term Impacts on the Human Throat and Gut Microbiome , 2010, PloS one.

[12]  M. Tomita,et al.  Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells , 2013, Nature.

[13]  Les Dethlefsen,et al.  The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing , 2008, PLoS biology.

[14]  G. Rook.  Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health , 2013, Proceedings of the National Academy of Sciences.

[15]  R. Hunkler,et al.  U.S. outpatient antibiotic prescribing, 2010. , 2013, The New England journal of medicine.

[16]  R. Knight,et al.  Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns , 2010, Proceedings of the National Academy of Sciences.

[17]  S. Zeissig,et al.  Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells , 2014, Cell.

[18]  K. Tanaka,et al.  The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. , 1997, Journal of immunology.

[19]  Leah M. Feazel,et al.  Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity , 2013, Science.

[20]  A. Macpherson,et al.  Interactions Between the Microbiota and the Immune System , 2012, Science.

[21]  D. P. Strachan,et al.  Hay fever, hygiene, and household size. , 1989, BMJ.

[22]  B. Finlay,et al.  Shifting the balance: antibiotic effects on host–microbiota mutualism , 2011, Nature Reviews Microbiology.

[23]  T. Sørensen,et al.  Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics , 2011, International Journal of Obesity.

[24]  Yunwei Wang,et al.  Dietary fat-induced taurocholic acid production promotes pathobiont and colitis in IL-10−/− mice , 2012, Nature.

[25]  Daniel B. DiGiulio,et al.  Development of the Human Infant Intestinal Microbiota , 2007, PLoS biology.

[26]  S. Ng,et al.  Geographical variability and environmental risk factors in inflammatory bowel disease , 2013, Gut.

[27]  Sebastian Reuter,et al.  Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. , 2011, The Journal of clinical investigation.

[28]  L. T. Angenent,et al.  Succession of microbial consortia in the developing infant gut microbiome , 2010, Proceedings of the National Academy of Sciences.

[29]  M. Hartmann,et al.  Early life antibiotic‐driven changes in microbiota enhance susceptibility to allergic asthma , 2012, EMBO reports.

[30]  Ronald P. DeMatteo,et al.  Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits , 2008, Nature.

[31]  K. Honda,et al.  Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species , 2011, Science.

[32]  J. Bach,et al.  The effect of infections on susceptibility to autoimmune and allergic diseases. , 2002, The New England journal of medicine.

[33]  Andre Franke,et al.  Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function , 2012, Science.

[34]  H. Sørensen,et al.  Use of penicillin and other antibiotics and risk of multiple sclerosis: a population-based case-control study. , 2012, American journal of epidemiology.

[35]  N. Sudo,et al.  Antibiotic use during infancy promotes a shift in the T(H)1/T(H)2 balance toward T(H)2-dominant immunity in mice. , 2001, The Journal of allergy and clinical immunology.

[36]  M. Hornef,et al.  The impact of perinatal immune development on mucosal homeostasis and chronic inflammation , 2011, Nature Reviews Immunology.

[37]  S. Akira,et al.  Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. , 2011, The Journal of clinical investigation.

[38]  A. McKenzie,et al.  Development of Allergic Airway Disease in Mice following Antibiotic Therapy and Fungal Microbiota Increase: Role of Host Genetics, Antigen, and Interleukin-13 , 2005, Infection and Immunity.

[39]  M. Blaser,et al.  What are the consequences of the disappearing human microbiota? , 2009, Nature Reviews Microbiology.

[40]  D. Kasper,et al.  A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease , 2010, Mucosal Immunology.

[41]  M. Blaser,et al.  Infant antibiotic exposures and early-life body mass , 2013, International Journal of Obesity.

[42]  H. Goossens,et al.  Outpatient antibiotic use in Europe and association with resistance: a cross-national database study , 2005, The Lancet.

[43]  V. Tremaroli,et al.  Functional interactions between the gut microbiota and host metabolism , 2012, Nature.

[44]  D. Nowak,et al.  Environmental exposure to endotoxin and its relation to asthma in school-age children. , 2002, The New England journal of medicine.

[45]  J. Clemente,et al.  Human gut microbiome viewed across age and geography , 2012, Nature.

[46]  M. Bracken,et al.  Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review , 2011, Pediatrics.

[47]  H. Williams,et al.  Atopic dermatitis and the ‘hygiene hypothesis’: too clean to be true? , 2005, The British journal of dermatology.